Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Gautam N. Bijur"'
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11014 (2010)
The low density lipoprotein receptor-related protein-6 (LRP6) is an essential co-receptor for canonical Wnt signaling. Dickkopf 1 (Dkk1), a major secreted Wnt signaling antagonist, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 c
Externí odkaz:
https://doaj.org/article/78f88e373e3a4898a98ac383403e6e64
Autor:
Emma Perez-Costas, Johanna C Gandy, Miguel Melendez-Ferro, Rosalinda C Roberts, Gautam N Bijur
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8911 (2010)
Glycogen synthase kinase-3beta (GSK3beta) is highly abundant in the brain. Various biochemical analyses have indicated that GSK3beta is localized to different intracellular compartments within brain cells. However, ultrastructural visualization of th
Externí odkaz:
https://doaj.org/article/99d6d0785a2d4390b6cea18a72776489
Autor:
Johanna C. Gandy, Emma Perez-Costas, Joy K. Roche, Miguel Melendez-Ferro, Benoit Lechat, David Demedts, Rosalinda C. Roberts, Gautam N. Bijur, Fred Van Leuven, Herman Devijver
Publikováno v:
Synapse. 67:313-327
Glycogen synthase kinase-3β (GSK3β) activity has been previously linked to Alzheimer's disease (AD) by its phosphorylation of tau and activation by amyloid. GSK3β intracellular distribution is important in regulating its activity by restricting ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6bbfd0c12dfbe03ca0ce4afee669485
https://doi.org/10.1002/syn.21642
https://doi.org/10.1002/syn.21642
Autor:
Rosalinda C. Roberts, Emma Perez-Costas, Johanna C. Gandy, Miguel Melendez-Ferro, Keri A. Barksdale, Gautam N. Bijur
Publikováno v:
The FASEB Journal. 24:3590-3599
Neuronal function in the brain requires energy in the form of ATP, and mitochondria are canonically associated with ATP production in neurons. The electrochemical gradient, which underlies the mitochondrial transmembrane potential (ΔΨmem), is harne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689e2601dc5fe81dd6884ec5c54948f2
https://doi.org/10.1096/fj.09-152108
https://doi.org/10.1096/fj.09-152108
Autor:
Gautam N. Bijur, Keri A. Barksdale
Publikováno v:
Journal of Neurochemistry. 108:1289-1299
Akt is a known client protein of heat shock protein 90 (HSP90). We have found that HSP90 is responsible for Akt accumulation in the mitochondria in unstimulated cells. Treatment of SH-SY5Y neuroblastoma cells and human embryonic kidney cells with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816eeffb26932e71942a2279c53f510e
https://doi.org/10.1111/j.1471-4159.2009.05878.x
https://doi.org/10.1111/j.1471-4159.2009.05878.x
Publikováno v:
Neurotoxicity Research. 14:367-382
GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate are well-established, but the effects of mitochondrial GSK3bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75157b9f9db17cf7b4a06f4ab00a8fd9
https://doi.org/10.1007/bf03033861
https://doi.org/10.1007/bf03033861
Autor:
Gautam N. Bijur, Richard S. Jope
Publikováno v:
Journal of Neurochemistry. 75:2401-2408
Elevated temperatures activate the survival promoters Akt and heat shock factor-1 (HSF-1), a transcription factor that induces the expression of heat shock proteins (HSPs), such as HSP-70. Because neuronal mechanisms controlling these responses are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7348f8479da59a1a97d0cbcd068057f
https://doi.org/10.1046/j.1471-4159.2000.0752401.x
https://doi.org/10.1046/j.1471-4159.2000.0752401.x
Publikováno v:
FEBS Letters. 580:3051-3058
The Ser/Thr kinase Akt1 is activated by growth factors subsequent to its phosphorylation on Thr308 and Ser473. In the present study, Akt1 was found to be constitutively modified with O-GlcNAc. Treatment of SH-SY5Y cells with O(2-acetamido-2-deoxy-d-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c669f1fd7ac50cd8cb8c1978753f799
https://doi.org/10.1016/j.febslet.2006.04.051
https://doi.org/10.1016/j.febslet.2006.04.051
Publikováno v:
Journal of Biological Chemistry. 278:48872-48879
The recent discovery of direct interactions between two important regulators of cell fate, the tumor suppressor p53 and glycogen synthase kinase-3beta (GSK3beta), led us to examine the mechanism and outcomes of this interaction. Two regions of p53 we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695709c204046decf8721a94ae369870
https://doi.org/10.1074/jbc.m305870200
https://doi.org/10.1074/jbc.m305870200
Autor:
Gautam N. Bijur, Richard S. Jope
Publikováno v:
NeuroReport. 14:2415-2419
Glycogen synthase kinase-3 beta (GSK3 beta) is located predominantly in the cytosol, but also is in nuclei and mitochondria. In SH-SY5Y cells, primary cortical neurons, and mouse brain, the portion of active GSK3 beta (not phosphorylated on serine-9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600d66c59a83579e864ad8d310a64769
https://doi.org/10.1097/00001756-200312190-00025
https://doi.org/10.1097/00001756-200312190-00025