Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Gautam Kao"'
Autor:
Dorota Raj, Bashar Kraish, Jari Martikainen, Agnieszka Podraza-Farhanieh, Gautam Kao, Peter Naredi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Cisplatin kills proliferating cells via DNA damage but also has profound effects on post-mitotic cells in tumors, kidneys, and neurons. However, the effects of cisplatin on post-mitotic cells are still poorly understood. Among model systems,
Externí odkaz:
https://doaj.org/article/e098cb21c00b416897f303d93b9bdcf5
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010538 (2022)
ASNA1 plays an essential role in cisplatin chemotherapy response, type 2 diabetes, and heart disease. It is also an important biomarker in the treatment response of many diseases. Biochemically, ASNA1 has two mutually exclusive redox-modulated roles:
Externí odkaz:
https://doaj.org/article/752f1373bbbf4d1fa484da3a7c840937
Autor:
Dorota Raj, Ola Billing, Agnieszka Podraza-Farhanieh, Bashar Kraish, Oskar Hemmingsson, Gautam Kao, Peter Naredi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Cisplatin is a frontline cancer therapeutic, but intrinsic or acquired resistance is common. We previously showed that cisplatin sensitivity can be achieved by inactivation of ASNA-1/TRC40 in mammalian cancer cells and in Caenorhabditis eleg
Externí odkaz:
https://doaj.org/article/584054111515443fbfc800bca074e800
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34507 (2012)
Genes regulating Caenorhabditis elegans insulin/IGF signaling (IIS) have largely been identified on the basis of their involvement in dauer development or longevity. A third IIS phenotype is the first larval stage (L1) diapause, which is also influen
Externí odkaz:
https://doaj.org/article/7cbe2af3902a497299ba0f994a8b0b64
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14507 (2011)
While insulin signaling has been extensively studied in Caenorhabditis elegans in the context of ageing and stress response, less is known about the factors underlying the secretion of insulin ligands upstream of the insulin receptor. Activation of t
Externí odkaz:
https://doaj.org/article/bd1c93cae7ad4e76b0d4ec4ea2aed84c
Publikováno v:
Development. 150
Neuropeptides, including insulin, are important regulators of physiological functions of the organisms. Trafficking through the Golgi is crucial for the regulation of secretion of insulin-like peptides. ASNA-1 (TRC40) and ENPL-1 (GRP94) are conserved
ASNA1 plays an essential role in cisplatin chemotherapy response, type 2 diabetes, and heart disease. It is also an important biomarker in the treatment response of many diseases. Biochemically, ASNA1 has two mutually exclusive redox modulated roles:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8bbb490fda5cb9342039f1e2abbf168
https://doi.org/10.1101/2022.07.12.499739
https://doi.org/10.1101/2022.07.12.499739
Maturation of insulin is crucial for insulin secretion and function. ENPL-1/GRP94/HSP90B1 plays an important role in this process. ASNA-1/TRC40/GET3 and ENPL-1/GRP94 are conserved insulin secretion regulators in Caenorhabditis elegans and mammals and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ba18b8f10362ed799bd7e5b2592b62
https://doi.org/10.1101/2022.06.15.496240
https://doi.org/10.1101/2022.06.15.496240
Autor:
Agnieszka, Podraza-Farhanieh, Balasubramanian, Natarajan, Dorota, Raj, Gautam, Kao, Peter, Naredi
Publikováno v:
Development (Cambridge, England). 147(20)
Insulin/IGF signaling in
Publikováno v:
Development.
Insulin/IGF signaling in C. elegans is crucial for proper development of the dauer larva and growth control. Mutants disturbing insulin processing, secretion and downstream signaling perturb this process and have helped identify genes that affect pro