Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Gautam Damera"'
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Benralizumab, a humanized, afucosylated, monoclonal antibody that targets interleukin-5 receptor α, depletes eosinophils and basophils by enhanced antibody-dependent cell-mediated cytotoxicity. It demonstrated efficacy for patien
Externí odkaz:
https://doaj.org/article/90a089f740a64c94927d146811d4e10a
Autor:
Gautam Damera, Kirk M Druey, Philip R Cooper, Vera P Krymskaya, Roy J Soberman, Yassine Amrani, Toshinori Hoshi, Christopher E Brightling, Reynold A Panettieri
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e28504 (2012)
In severe asthma, bronchodilator- and steroid-insensitive airflow obstruction develops through unknown mechanisms characterized by increased lung airway smooth muscle (ASM) mass and stiffness. We explored the role of a Regulator of G-protein Signalin
Externí odkaz:
https://doaj.org/article/de3e4fc546244df895c5429b8532ccfe
Autor:
Mohammad Kiumarsi, P. Sravan Kumar, Sanaz Dastghaib, Sukhwinder Singh Sohal, Sudharsana R. Ande, Azadeh Dalvand, Sajjad Aftabi, Amir A. Zeki, Adel Sepanjnia, Mohamad Reza Aghanoori, Pawan K. Sharma, Gautam Damera, Pooneh Mokarram, Javad Alizadeh, Saeid Ghavami
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 64:29-38
Lung cells are constantly exposed to various internal and external stressors that disrupt protein homeostasis. To cope with these stimuli, cells evoke a highly conserved adaptive mechanism called the unfolded protein response (UPR). UPR stressors can
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-12 (2019)
Respiratory Research
Respiratory Research
Background Benralizumab, a humanized, afucosylated, monoclonal antibody that targets interleukin-5 receptor α, depletes eosinophils and basophils by enhanced antibody-dependent cell-mediated cytotoxicity. It demonstrated efficacy for patients with m
Publikováno v:
Respiratory Medicine. 111:21-29
Eosinophilic inflammation is frequently associated with increased asthma severity. Benralizumab is a humanized, afucosylated, anti-interleukin-5Rα monoclonal antibody that selectively depletes eosinophils and basophils through enhanced antibody-depe
Autor:
Katherine Stephenson, Michiko Mori, Sanjay Sethi, Christine K. Ward, Jonas S. Erjefält, Natasha A. Karp, Gautam Damera, Donna K. Finch, Emmanuel Briend, G. John Ferguson, Matthew A. Sleeman
Publikováno v:
Respiratory Research
Background Increased interferon gamma (IFNγ) release occurs in Chronic Obstructive Pulmonary Disease (COPD) lungs. IFNγ supports optimal viral clearance, but if dysregulated could increase lung tissue destruction. Methods The present study investig
Autor:
Dave Singh, Paul Newbold, Tuyet-Hang Pham, Gautam Damera, Umme Kolsum, Thomas Southworth, Sarah Mason, Pradeep Karur
Publikováno v:
The Journal of allergy and clinical immunology. 140(4)
Autor:
Richard M. Martin, Edward Piper, Chrisopher E. Brightling, Philip Brohawn, Gautam Damera, Dewei She, Inna Vainshtein, Meina Liang, Scott Martinez, Koustubh Ranade, Tuyet-Hang Pham, Katie Streicher, Fernanda Pilataxi, Michael Kuziora
Publikováno v:
5.1 Airway Pharmacology and Treatment.
RATIONALE: We sought biomarkers to identify asthma patients (pts) likely to benefit from tralokinumab, an anti–IL-13 IgG4 monoclonal antibody. METHODS: Airway epithelial cells grown in air-liquid interface cultures were stimulated with cytokines wi
Publikováno v:
5.1 Airway Pharmacology and Treatment.
Background: Benralizumab depletes eosinophils and basophils by enhanced antibody-dependent cell-mediated cytotoxicity, and has demonstrated efficacy for pts with moderate to severe asthma or COPD with eosinophilic inflammation. 1,2 Objectives: We inv
Autor:
Sanjay Sethi, Koustubh Ranade, Tuyet-Hang Pham, Jianchun Zhang, Christine K. Ward, Gautam Damera, Paul Newbold
Publikováno v:
Lung. 194(3)
Activation of the interleukin-1β (IL-1β) signaling pathway has been implicated in COPD, but the proportion of COPD subjects whose disease is principally driven by activation of this pathway is poorly understood. In this study, we sought to differen