Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Gautam Adhikary"'
Autor:
Eric W. J. Gates, Nicholas D. Calvert, Nicholas J. Cundy, Federica Brugnoli, Pauline Navals, Alexia Kirby, Nicoletta Bianchi, Gautam Adhikary, Adam J. Shuhendler, Richard L. Eckert, Jeffrey W. Keillor
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12546 (2023)
Transglutaminase 2 (TG2) is a multifunctional enzyme primarily responsible for crosslinking proteins. Ubiquitously expressed in humans, TG2 can act either as a transamidase by crosslinking two substrates through formation of an Nε(ɣ-glutaminyl)lysi
Externí odkaz:
https://doaj.org/article/cc08aac5a3ef4e499a2f325c29def26c
Autor:
Suruchi Shrestha, Gautam Adhikary, Warren Naselsky, Wen Xu, Joseph S. Friedberg, Richard L. Eckert
Publikováno v:
Oncogenesis, Vol 10, Iss 10, Pp 1-11 (2021)
Abstract Mesothelioma is a poor prognosis cancer of the mesothelial lining that develops in response to exposure to various agents including asbestos. Actin-Like Protein 6A (ACTL6A, BAF53a) is a SWI/SNF regulatory complex protein that is elevated in
Externí odkaz:
https://doaj.org/article/438e94a78e624c2ab8adadf80cce0306
Autor:
Gautam Adhikary, Dan Grun, Candace Kerr, Sivaprakasam Balasubramanian, Ellen A Rorke, Mohan Vemuri, Shayne Boucher, Jackie R Bickenbach, Thomas Hornyak, Wen Xu, Matthew L Fisher, Richard L Eckert
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84324 (2013)
Epidermal squamous cell carcinoma is among the most common cancers in humans. These tumors are comprised of phenotypically diverse populations of cells that display varying potential for proliferation and differentiation. An important goal is identif
Externí odkaz:
https://doaj.org/article/7afd711611d84be8b21094474786d065
Autor:
Richard L. Eckert, Gautam Adhikary, Christina A. Young, Ralph Jans, James F. Crish, Wen Xu, Ellen A. Rorke
Publikováno v:
Journal of Skin Cancer, Vol 2013 (2013)
AP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key regulators of epidermal keratinocyte survival and differentiation and important drivers of cancer development. Understanding the role of these factors in e
Externí odkaz:
https://doaj.org/article/f143e49a7dba48b9b21a503214da0e09
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36941 (2012)
Our previous study shows that inhibiting activator protein one (AP1) transcription factor function in murine epidermis, using dominant-negative c-jun (TAM67), increases cell proliferation and delays differentiation. To understand the mechanism of act
Externí odkaz:
https://doaj.org/article/db43e9b5b84b4cf1a4cbe61ac8d7ec02
Autor:
Gautam Adhikary, Erica L. Heipertz, Maja Preradovic, Xi Chen, Wen Xu, John J. Newland, Navjot Kaur, Mohan C. Vemuri, Richard L. Eckert
Publikováno v:
Molecular Carcinogenesis. 62:845-854
Autor:
Nicholas J. Cundy, Jane Arciszewski, Eric W. J. Gates, Sydney L. Acton, Kyle D. Passley, Ernest Awoonor-Williams, Elizabeth K. Boyd, Nancy Xu, Élise Pierson, Catalina Fernandez-Ansieta, Marie R. Albert, Nicole M. R. McNeil, Gautam Adhikary, Richard L. Eckert, Jeffrey W. Keillor
Publikováno v:
RSC Medicinal Chemistry. 14:378-385
A novel peptidic scaffold was used to design a library of inhibitors that exhibit exceptional efficiency against tissue transglutaminase, providing a framework for the development of potent research tools.
Autor:
Xi Chen, Gautam Adhikary, John J. Newland, Wen Xu, Jeffrey W. Keillor, David J. Weber, Richard L. Eckert
Publikováno v:
Molecular Cancer Research.
Transglutaminase 2 (TG2) is a key cancer cell survival protein in many cancer types. As such, efforts are underway to characterize the mechanism of TG2 action. In the present study we report that TG2 stimulates CD44v6 activity to enhance cancer cell
Autor:
Xi Chen, Gautam Adhikary, John J. Newland, Wen Xu, Emily Ma, Warren Naselsky, Richard L. Eckert
Publikováno v:
Molecular Carcinogenesis. 62:90-100
Transglutaminase 2 (TG2) is an important cancer stem-like cell survival protein that is highly expressed in epidermal squamous cell carcinoma and drives an aggressive cancer phenotype. In the present study, we show that TG2 knockdown or inactivation
Transglutaminase 2 Maintains Hepatocyte Growth Factor Signaling to Enhance the Cancer Cell Phenotype
Autor:
Warren Naselsky, Wen Xu, Xi Chen, Suruchi Shrestha, Gautam Adhikary, Jeffrey W. Keillor, Richard L. Eckert
Publikováno v:
Mol Cancer Res
Transglutaminase 2 (TG2) is a key epidermal squamous cell carcinoma cancer cell survival protein. However, how TG2 maintains the aggressive cancer phenotype is not well understood. The present studies show that TG2, which is highly expressed in epide