Zobrazeno 1 - 10
of 681
pro vyhledávání: '"Gautam, Sethi"'
Autor:
Babu Santha Aswani, Mangala Hegde, Ravichandran Vishwa, Mohammed S. Alqahtani, Mohamed Abbas, Hassan Ali Almubarak, Gautam Sethi, Ajaikumar B. Kunnumakkara
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-39 (2024)
Abstract Nuclear receptors (NRs) function as crucial transcription factors in orchestrating essential functions within the realms of development, host defense, and homeostasis of body. NRs have garnered increased attention due to their potential as t
Externí odkaz:
https://doaj.org/article/fff136fccb7041f48f03d158c36f1e3d
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-28 (2024)
Abstract Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune systems, significantly influencing various physiological processes such as cell proliferation, migration, differentiation, survival, and stemness. The fun
Externí odkaz:
https://doaj.org/article/fbaaff45cfe44ba486d68af52f8e2194
Autor:
Xian-Bin Zhang, Yi-Bao Fan, Rui Jing, Mikiyas Amare Getu, Wan-Ying Chen, Wei Zhang, Hong-Xia Dong, Tikam Chand Dakal, Akhtar Hayat, Hua-Jun Cai, Milad Ashrafizadeh, A. M. Abd El-Aty, Ahmet Hacimuftuoglu, Peng Liu, Tian-Feng Li, Gautam Sethi, Kwang Seok Ahn, Yavuz Nuri Ertas, Min-Jiang Chen, Jian-Song Ji, Li Ma, Peng Gong
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-20 (2024)
Abstract Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common subtype of NE
Externí odkaz:
https://doaj.org/article/ed6a827f8f5c41eca1a2004d234b6cf5
Autor:
Le Cheng, Limin Zhang, Xiaoxiao Wang, Yufei Wang, Jiahui Yu, Mengnan Li, Zhaowu Ma, Paul Chi-Lui Ho, Xiaoguang Chen, Lingzhi Wang, Gautam Sethi, Boon-Cher Goh
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107419- (2024)
Hepatocellular carcinoma (HCC) stands as the sixth most prevalent cancer and the third leading cause of cancer mortality globally. Despite surgical resection being the preferred approach for early-stage HCC, most patients are diagnosed at intermediat
Externí odkaz:
https://doaj.org/article/70f31f83321e445c8d89a965930617ee
Autor:
Na Young Kim, Dukanya Dukanya, Gautam Sethi, Swamy S Girimanchanaika, Jirui Yang, Omantheswara Nagaraja, Ananda Swamynayaka, Divakar Vishwanath, Keerthikumara Venkantesha, Shreeja Basappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Mahendra Madegowda, Alexey Sukhorukov, Vijay Pandey, Peter E. Lobie, Basappa Basappa, Kwang Seok Ahn
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102101- (2024)
Small molecule-driven JNK activation has been found to induce apoptosis and paraptosis in cancer cells. Herein pharmacological effects of synthetic oxazine (4aS, 7aS)-3-((4-(4‑chloro-2-fluorophenyl)piperazin-1-yl)methyl)-4-phenyl-4, 4a, 5, 6, 7, 7a
Externí odkaz:
https://doaj.org/article/6719bc3a38394d8688d5d7884b2aea4a
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38193- (2024)
Breast cancer is a highly complex disease with multiple subtypes. While many of the breast cancer cases are sporadic some can be familial or hereditary. Genomic integrity is closely monitored by several mechanisms, such as DNA damage machinery and mi
Externí odkaz:
https://doaj.org/article/d8fc13f62c4647c5a7f1c361649cda48
Autor:
Olga A. Sukocheva, Margarita E. Neganova, Yulia Aleksandrova, Jack T. Burcher, Elena Chugunova, Ruitai Fan, Edmund Tse, Gautam Sethi, Anupam Bishayee, Junqi Liu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-40 (2024)
Abstract Anticancer immune surveillance and immunotherapies trigger activation of cytotoxic cytokine signaling, including tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing ligand (TRAIL) pathways. The pro-inflammatory cytokine TNF-
Externí odkaz:
https://doaj.org/article/3f34fcd20ba7425ab38ab6412822252b
Autor:
Qiang Lu, Dongquan Kou, Shenghan Lou, Milad Ashrafizadeh, Amir Reza Aref, Israel Canadas, Yu Tian, Xiaojia Niu, Yuzhuo Wang, Pedram Torabian, Lingzhi Wang, Gautam Sethi, Vinay Tergaonkar, Franklin Tay, Zhennan Yuan, Peng Han
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-48 (2024)
Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in the clinical delivery of immunomodulatory compounds. The tumor microenvironmen
Externí odkaz:
https://doaj.org/article/a9c4064eb78943919ff730793f464b33
Autor:
Fangqi Ma, Mingming Ren, Zhongqiu Li, Yujing Tang, Xiaoyu Sun, Yi Wang, Nida Cao, Xiaohong Zhu, Yan Xu, Rui Wang, Yumiao Shen, Ruohan Zhao, Zhaoyan Li, Milad Ashrafizadeh, Gautam Sethi, Furong Wang, Aiguang Zhao
Publikováno v:
Pharmacological Research, Vol 210, Iss , Pp 107499- (2024)
ARID1A deletion mutation contributes to improved treatment of several malignancies with immune checkpoint inhibitors (ICIs). However, its role in modulating of tumor immune microenvironment (TIME) of gastric cancer (GC) remains unclear. Here, we repo
Externí odkaz:
https://doaj.org/article/6edfe2f16e934a929e551f3d8ed57aab
Autor:
Anjana Sajeev, Bandari BharathwajChetty, Mukesh Kumar Manickasamy, Mohammed S. Alqahtani, Mohamed Abbas, Mehdi Shakibaei, Gautam Sethi, Zhaowu Ma, Ajaikumar B. Kunnumakkara
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Ovarian cancer (OVC) is one of the most common causes of cancer-related deaths in women worldwide. Despite advancements in detection and therapy, the prognosis of OVC remains poor due to late diagnosis and the lack of effective therapeutic options at
Externí odkaz:
https://doaj.org/article/8e77faa1ada94f2cbf9bb53249a735da