How Gaussian mixture modelling can help to verify reference intervals from laboratory data with a high proportion of pathological values

Autor: Hoffmann Georg, Allmeier Nina, Kuti Modupe, Holdenrieder Stefan, Trulson Inga

Publikováno v: Journal of Laboratory Medicine, Vol 48, Iss 5, Pp 251-258 (2024)

Although there are several indirect methods that can be used to verify reference limits, they have a common weakness in that they assume a low proportion of pathological values. This paper investigates whether a Gaussian decomposition algorithm can i

Externí odkaz: https://doaj.org/article/4a338c786f2945a3a441e374e17951b8

Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts

Autor: Flora H. Duits, Kirsten E. J. Wesenhagen, Laura Ekblad, Emma Wolters, Eline A. J. Willemse, ADNI, Philip Scheltens, Wiesje M. van der Flier, Charlotte E. Teunissen, Pieter Jelle Visser, Betty M. Tijms

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-25 (2021)

Abstract Background As Alzheimer’s disease (AD) pathology presents decades before dementia manifests, unbiased biomarker cut-points may more closely reflect presence of pathology than clinically defined cut-points. Currently, unbiased cerebrospinal

Externí odkaz: https://doaj.org/article/efd993577f5d47908e8a57e1a7f456c8

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Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts

Autor: Betty M. Tijms, Eline A.J. Willemse, Pieter Jelle Visser, Flora H. Duits, Wiesje M. van der Flier, Kirsten E. J. Wesenhagen, Charlotte E. Teunissen, Emma E. Wolters, Laura Ekblad, Philip Scheltens

Publikováno v: Duits, F H, Wesenhagen, K E J, Ekblad, L, Wolters, E, Willemse, E A J, Scheltens, P, van der Flier, W M, Teunissen, C E, ADNI, Visser, P J & Tijms, B M 2021, ' Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts ', Alzheimer's Research and Therapy, vol. 13, no. 1, 2 . https://doi.org/10.1186/s13195-020-00713-3
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-25 (2021)
Alzheimer's Research & Therapy, 13(1):2. BioMed Central Ltd
Alzheimer's Research and Therapy, 13(1):2. BioMed Central

Background As Alzheimer’s disease (AD) pathology presents decades before dementia manifests, unbiased biomarker cut-points may more closely reflect presence of pathology than clinically defined cut-points. Currently, unbiased cerebrospinal fluid (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2f82ad37b634318a17408b8e7f77cd
https://research.vumc.nl/en/publications/cf68ac9e-2305-4925-92f6-0ff6d0b7524f