Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder

Autor: Gauri G. Shastri, Gustavo Sudre, Kwangmi Ahn, Benjamin Jung, Bhaskar Kolachana, Pavan K. Auluck, Laura Elnitski, Stefano Marenco, Philip Shaw

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract While epigenetic modifications have been implicated in ADHD through studies of peripheral tissue, to date there has been no examination of the epigenome of the brain in the disorder. To address this gap, we mapped the methylome of the caudat

Externí odkaz: https://doaj.org/article/2c32eceaeaf948eab815ff3f112ba7c8

Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder

Autor: Gustavo Sudre, Derek E. Gildea, Gauri G. Shastri, Wendy Sharp, Benjamin Jung, Qing Xu, Pavan K. Auluck, Laura Elnitski, Andreas D. Baxevanis, Stefano Marenco, Philip Shaw

Publikováno v: Molecular Psychiatry. 28:792-800

Despite advances in identifying rare and common genetic variants conferring risk for ADHD, the lack of a transcriptomic understanding of cortico-striatal brain circuitry has stymied a molecular mechanistic understanding of this disorder. To address t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0852fecfbe663edc06a8f7ff8afeb9
https://doi.org/10.1038/s41380-022-01844-9

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Autor: Taren Thron, Sarkis K. Mazmanian, Mark S. Ladinsky, István T. Horváth, Anastasiya Moiseyenko, Neha Jain, Viviana Gradinaru, Rob Knight, Gauri G. Shastri, Timothy R. Sampson, Pernilla Wittung-Stafshede, Brittany D. Needham, Collin Challis, Matthew George Chapman, Stefan Janssen, Justine W. Debelius

Publikováno v: eLife, Vol 9 (2020)
eLife

Amyloids are a class of protein with unique self-aggregation properties, and their aberrant accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. While genetic and environmental factors can influence amyloid forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f412538818882f976d0c42055e52f4e
https://escholarship.org/uc/item/1nh000p8

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Autor: Collin Challis, Sarkis K. Mazmanian, Catherine E. Schretter, Ali Keshavarzian, Zehra Esra Ilhan, Timothy R. Sampson, Justine W. Debelius, Rosa Krajmalnik-Brown, Stefan Janssen, Taren Thron, Viviana Gradinaru, Marie-Françoise Chesselet, Gauri G. Shastri, Pernilla Wittung-Stafshede, Rob Knight, Sandra Rocha, Kathleen M. Shannon

Publikováno v: Cell, vol 167, iss 6

The intestinal microbiota influence neurodevelopment, modulate behavior, and contribute to neurological disorders. However, a functional link between gut bacteria and neurodegenerative diseases remains unexplored. Synucleinopathies are characterized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b7fe5563898f8ce8181ca26f7977c6
https://doi.org/10.1016/j.cell.2016.11.018

A daily diary study into the effects on mental health of COVID-19 pandemic-related behaviors.

Autor: Shaw P; Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA.; National Institute of Mental Health, Bethesda, MD, USA., Blizzard S; Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA., Shastri G; Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA., Kundzicz P; National Institute of Mental Health, Bethesda, MD, USA., Curtis B; Translational Addiction Medicine Branch, Technology and Translational Research Unit, National Institute of Drug Abuse, Baltimore, MD, USA., Ungar L; Computer and Information Science, University of Pennsylvania, Philadelphia, PA, USA., Koehly L; Social Network Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA.

Publikováno v: Psychological medicine [Psychol Med] 2023 Jan; Vol. 53 (2), pp. 524-532. Date of Electronic Publication: 2021 Jul 12.