Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gauri G. Shastri"'
Autor:
Gauri G. Shastri, Gustavo Sudre, Kwangmi Ahn, Benjamin Jung, Bhaskar Kolachana, Pavan K. Auluck, Laura Elnitski, Philip Shaw
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Mathematical algorithms known as “epigenetic clocks” use methylation values at a set of CpG sites to estimate the biological age of an individual in a tissue-specific manner. These clocks have demonstrated both acceleration and delays in epigenet
Externí odkaz:
https://doaj.org/article/cb44e07a18434e18ba05a229218d9b77
Autor:
Gauri G. Shastri, Gustavo Sudre, Kwangmi Ahn, Benjamin Jung, Bhaskar Kolachana, Pavan K. Auluck, Laura Elnitski, Stefano Marenco, Philip Shaw
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract While epigenetic modifications have been implicated in ADHD through studies of peripheral tissue, to date there has been no examination of the epigenome of the brain in the disorder. To address this gap, we mapped the methylome of the caudat
Externí odkaz:
https://doaj.org/article/2c32eceaeaf948eab815ff3f112ba7c8
Autor:
Timothy R Sampson, Collin Challis, Neha Jain, Anastasiya Moiseyenko, Mark S Ladinsky, Gauri G Shastri, Taren Thron, Brittany D Needham, Istvan Horvath, Justine W Debelius, Stefan Janssen, Rob Knight, Pernilla Wittung-Stafshede, Viviana Gradinaru, Matthew Chapman, Sarkis K Mazmanian
Publikováno v:
eLife, Vol 9 (2020)
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. While genetic and environmental factors can influence amyloid forma
Externí odkaz:
https://doaj.org/article/a828d9d829724627bc449f3bc4f8d4bc
Autor:
Gustavo Sudre, Derek E. Gildea, Gauri G. Shastri, Wendy Sharp, Benjamin Jung, Qing Xu, Pavan K. Auluck, Laura Elnitski, Andreas D. Baxevanis, Stefano Marenco, Philip Shaw
Publikováno v:
Molecular Psychiatry. 28:792-800
Despite advances in identifying rare and common genetic variants conferring risk for ADHD, the lack of a transcriptomic understanding of cortico-striatal brain circuitry has stymied a molecular mechanistic understanding of this disorder. To address t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0852fecfbe663edc06a8f7ff8afeb9
https://doi.org/10.1038/s41380-022-01844-9
https://doi.org/10.1038/s41380-022-01844-9
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
We sought to identify resting-state characteristics related to attention deficit/hyperactivity disorder, both as a categorical diagnosis and as a trait feature, using large-scale samples which were processed according to a standardized pipeline. In c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8afeb91aefd86fc296659b627cdd608
https://pubmed.ncbi.nlm.nih.gov/36100657
https://pubmed.ncbi.nlm.nih.gov/36100657
Autor:
Taren Thron, Sarkis K. Mazmanian, Mark S. Ladinsky, István T. Horváth, Anastasiya Moiseyenko, Neha Jain, Viviana Gradinaru, Rob Knight, Gauri G. Shastri, Timothy R. Sampson, Pernilla Wittung-Stafshede, Brittany D. Needham, Collin Challis, Matthew George Chapman, Stefan Janssen, Justine W. Debelius
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. While genetic and environmental factors can influence amyloid forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f412538818882f976d0c42055e52f4e
https://escholarship.org/uc/item/1nh000p8
https://escholarship.org/uc/item/1nh000p8
Autor:
Matthew George Chapman, Brittany D. Needham, Rob Knight, Collin Challis, Stefan Janssen, István T. Horváth, Anastasiya Moiseyenko, Pernilla Wittung-Stafshede, Neha Jain, Sarkis K. Mazmanian, Justine W. Debelius, Viviana Gradinaru, Gauri G. Shastri, Timothy R. Sampson, Taren Thron, Mark S. Ladinsky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::993ab106121d07e13dc835fab459f2cf
https://doi.org/10.7554/elife.53111.sa2
https://doi.org/10.7554/elife.53111.sa2
Autor:
Collin Challis, Sarkis K. Mazmanian, Catherine E. Schretter, Ali Keshavarzian, Zehra Esra Ilhan, Timothy R. Sampson, Justine W. Debelius, Rosa Krajmalnik-Brown, Stefan Janssen, Taren Thron, Viviana Gradinaru, Marie-Françoise Chesselet, Gauri G. Shastri, Pernilla Wittung-Stafshede, Rob Knight, Sandra Rocha, Kathleen M. Shannon
Publikováno v:
Cell, vol 167, iss 6
The intestinal microbiota influence neurodevelopment, modulate behavior, and contribute to neurological disorders. However, a functional link between gut bacteria and neurodegenerative diseases remains unexplored. Synucleinopathies are characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b7fe5563898f8ce8181ca26f7977c6
https://doi.org/10.1016/j.cell.2016.11.018
https://doi.org/10.1016/j.cell.2016.11.018
Autor:
Kristie B. Yu, Gauri G. Shastri, Liang Ma, Phoebe Ann, Rustem F. Ismagilov, Jessica M. Yano, Gregory P. Donaldson, Sarkis K. Mazmanian, Elaine Y. Hsiao, Cathryn R. Nagler
SummaryThe gastrointestinal (GI) tract contains much of the body’s serotonin (5-hydroxytryptamine, 5-HT), but mechanisms controlling the metabolism of gut-derived 5-HT remain unclear. Here, we demonstrate that the microbiota plays a critical role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3adc84c15ab1dc64108ebeafd04e5c
https://resolver.caltech.edu/CaltechAUTHORS:20150409-093248232
https://resolver.caltech.edu/CaltechAUTHORS:20150409-093248232
Publikováno v:
Mental Health Weekly Digest; 10/25/2024, p1294-1294, 1p