Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Gauri G. Rao"'
Autor:
Maytham Hussein, Zhisen Kang, Stephanie L. Neville, Rafah Allobawi, Varsha Thrombare, Augustine Jing Jie Koh, Jonathan Wilksch, Simon Crawford, Mudher Khudhur Mohammed, Christopher A. McDevitt, Mark Baker, Gauri G. Rao, Jian Li, Tony Velkov
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract This untargeted metabolomics study investigated the synergistic antibacterial activity of polymyxin B and Leu10-teixobactin, a depsipeptide inhibitor of cell wall biosynthesis. Checkerboard microdilution assays revealed a significant synergy
Externí odkaz:
https://doaj.org/article/65aae9e3f2a849c3b03fce0edc5edfad
Autor:
Maytham Hussein, Zetao Sun, Jane Hawkey, Rafah Allobawi, Louise M. Judd, Vincenzo Carbone, Rajnikant Sharma, Varsha Thombare, Mark Baker, Gauri G. Rao, Jian Li, Kathryn E. Holt, Tony Velkov
Publikováno v:
mSystems, Vol 9, Iss 1 (2024)
ABSTRACTNitrofurantoin is a commonly used chemotherapeutic agent in the treatment of uncomplicated urinary tract infections caused by the problematic multidrug resistant Gram-negative pathogen Klebsiella pneumoniae. The present study aims to elucidat
Externí odkaz:
https://doaj.org/article/a020996758a44aecb63f2ae7a08f1d44
Autor:
Patrick O. Hanafin, Nusaibah Abdul Rahim, Rajnikant Sharma, Colin G. Cess, Stacey D. Finley, Phillip J. Bergen, Tony Velkov, Jian Li, Gauri G. Rao
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 3, Pp 387-400 (2023)
Abstract Carbapenemase‐resistant Klebsiella pneumoniae (KP) resistant to multiple antibiotic classes necessitates optimized combination therapy. Our objective is to build a workflow leveraging omics and bacterial count data to identify antibiotic m
Externí odkaz:
https://doaj.org/article/b1a4cb3284184248a58740d3ca208309
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Antibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years. In this context, an urgent need to develop new stra
Externí odkaz:
https://doaj.org/article/ed517d4f7d70407991ecf69ae72cf14d
Autor:
Maytham Hussein, Sara Oberrauch, Rafah Allobawi, Linda Cornthwaite-Duncan, Jing Lu, Rajnikant Sharma, Mark Baker, Jian Li, Gauri G. Rao, Tony Velkov
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6067-6077 (2022)
There is a dearth of studies focused on understanding pharmacokinetics, pharmacodynamics and toxicodynamics of polymyxins following direct administration to the central nervous system (CNS). In this study, for the first time, untargeted metabolomics
Externí odkaz:
https://doaj.org/article/cc10edd91d624340b9335629527d490a
Autor:
Maytham Hussein, Labell J.M. Wong, Jinxin Zhao, Vanessa E. Rees, Rafah Allobawi, Rajnikant Sharma, Gauri G. Rao, Mark Baker, Jian Li, Tony Velkov
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1077-1087 (2022)
Klebsiella pneumoniae is an opportunistic Gram-negative pathogen causing nosocomial infections. K. pneumoniae rapidly acquires antibiotic resistance and is known as a reservoir for resistance genes. Polymyxins remain effective as a last-line therapy
Externí odkaz:
https://doaj.org/article/af71853ef9784f8183b9c282686bd8b7
Autor:
Maytham Hussein, Raad Jasim, Hakan Gocol, Mark Baker, Varsha J. Thombare, James Ziogas, Aayush Purohit, Gauri G. Rao, Jian Li, Tony Velkov
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria serve as transporters for the delivery of cargo such as virulence and antibiotic resistance factors. OMVs play a key role in the defense against membrane-targeting antibiotics
Externí odkaz:
https://doaj.org/article/728696dabd9445b7b5873a87b878e4c6
Autor:
Patrick O. Hanafin, Roger L. Nation, Marc H. Scheetz, Alexandre P. Zavascki, Ana M. Sandri, Andrea L. Kwa, Benjamin P. Z. Cherng, Christine J. Kubin, Michael T. Yin, Jiping Wang, Jian Li, Keith S. Kaye, Gauri G. Rao
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 12, Pp 1525-1537 (2021)
Abstract Polymyxin B (PMB) has reemerged as a last‐line therapy for infections caused by multidrug‐resistant gram‐negative pathogens, but dosing is challenging because of its narrow therapeutic window and pharmacokinetic (PK) variability. Popul
Externí odkaz:
https://doaj.org/article/90ef046582c94502abeab347f50b51a1
Autor:
Patrick O. Hanafin, Brian Jermain, Anthony J. Hickey, Alexander V. Kabanov, Angela DM. Kashuba, Timothy P. Sheahan, Gauri G. Rao
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 89-99 (2021)
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) outbreak initiated the global coronavirus disease 2019 (COVID‐19) pandemic resulting in 42.9 million confirmed infections and > 1.1 million deaths worldwide as of October
Externí odkaz:
https://doaj.org/article/bda925b05d3b4d6ab7b8cfb0cdce9b1b
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 10, Pp 596-605 (2020)
The ability to control dosage regimens of erythropoiesis‐stimulating agents (ESAs) to maintain a desired hemoglobin (HGB) target is still elusive. We utilized a Bayesian approach and informative priors to characterize HGB profiles, using simulated
Externí odkaz:
https://doaj.org/article/6b67f059e82148bdbbaa3467ef1c5b14