Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Gaurav Pathria"'
Autor:
Saumya D. Sisoudiya, Armande Ang Houle, Tharu Fernando, Timothy R. Wilson, Jennifer L. Schutzman, Jessica Lee, Alexa Schrock, Ethan S. Sokol, Smruthy Sivakumar, Zhen Shi, Gaurav Pathria
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract Racial/ethnic disparities mar NSCLC care and treatment outcomes. While socioeconomic factors and access to healthcare are important drivers of NSCLC disparities, a deeper understanding of genetic ancestry-associated genomic landscapes can be
Externí odkaz:
https://doaj.org/article/e17253d3815e43a3a04a59cd636197a4
Autor:
Ahmad Jalili, Kirsten D Mertz, Julia Romanov, Christine Wagner, Frank Kalthoff, Anton Stuetz, Gaurav Pathria, Melanie Gschaider, Georg Stingl, Stephan N Wagner
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69064 (2013)
Melanoma is one of the most aggressive cancers and its incidence is increasing worldwide. So far there are no curable therapies especially after metastasis. Due to frequent mutations in members of the mitogen-activated protein kinase (MAPK) signaling
Externí odkaz:
https://doaj.org/article/9c2af3532f6f4c2db3d5beaf636d21d8
Autor:
Ahmad Jalili, Kirsten D. Mertz, Julia Romanov, Christine Wagner, Frank Kalthoff, Anton Stuetz, Gaurav Pathria, Melanie Gschaider, Georg Stingl, Stephan N. Wagner
Publikováno v:
PLoS ONE, Vol 8, Iss 9 (2013)
Externí odkaz:
https://doaj.org/article/0de567f441f44ff6a4e5b3c0d1e53cb4
Autor:
Ze'ev A. Ronai, David A. Scott, Jun Yin, Brian James, Michael Jackson, Susanne Heynen-Genel, Gaurav Pathria, Yongmei Feng
Supp fig 1-8: Figure S1. Inhibition of SLC1A5 Expression in A431 cells. Figure S2. Screen and Validation of Hits. Figure S3. IMD-0354 inhibited Glutamine Uptake. Figure S4. IMD-0354 Suppresses Glutamine Uptake Independent of IKK-NF- B Signaling Suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f59ce5b6b54f9924768dedc2997ec3
https://doi.org/10.1158/1535-7163.22522782
https://doi.org/10.1158/1535-7163.22522782
Autor:
Ze'ev A. Ronai, David A. Scott, Jun Yin, Brian James, Michael Jackson, Susanne Heynen-Genel, Gaurav Pathria, Yongmei Feng
Supp Tables 1-2: Table S1 List of hits selected from the primary screen. Table S2. Chemical structures of hits selected for validation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42964a2f659b0e7e9dd23e36454d089c
https://doi.org/10.1158/1535-7163.22522779
https://doi.org/10.1158/1535-7163.22522779
Autor:
Sachin Verma, David Crawford, Ali Khateb, Yongmei Feng, Eduard Sergienko, Gaurav Pathria, Chen-Ting Ma, Steven H. Olson, David Scott, Rabi Murad, Eytan Ruppin, Michael Jackson, Ze’ev A. Ronai
Publikováno v:
Nat Cell Biol
Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d4299a68863154ef2339bde519cb8e
https://europepmc.org/articles/PMC9977532/
https://europepmc.org/articles/PMC9977532/
Identification and Characterization of IMD-0354 as a Glutamine Carrier Protein Inhibitor in Melanoma
Autor:
Susanne Heynen-Genel, Gaurav Pathria, David Scott, Yongmei Feng, Michael R. Jackson, Brian P. James, Ze'ev Ronai, Jun Yin
Publikováno v:
Mol Cancer Ther
A key hallmark of cancer, altered metabolism, is central to cancer pathogenesis and therapy resistance. Robust glutamine metabolism is among cellular processes regulating tumor progression and responsiveness to therapy in a number of cancers, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fb13c1db9d25ce6654592f7852f4d9
https://doi.org/10.1158/1535-7163.mct-20-0354
https://doi.org/10.1158/1535-7163.mct-20-0354
Autor:
Eytan Ruppin, Ivan Topisirovic, Erez Hasnis, David Scott, Ze'ev Ronai, Lionel Larue, Avinash Das Sahu, Joo Sang Lee, Yongmei Feng, Kristofferson Tandoc, Sachin Verma, Gaurav Pathria
Publikováno v:
Nature cell biology
While amino acid restriction remains an attractive strategy for cancer therapy, metabolic adaptations limit its effectiveness. Here we demonstrate a role of translational reprogramming in the survival of asparagine-restricted cancer cells. Asparagine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8828ae5fe52d43610f53ea90356dafd5
http://europepmc.org/articles/PMC7307327
http://europepmc.org/articles/PMC7307327
Publikováno v:
EMBO Rep
Amino acid restriction is among promising potential cancer treatment strategies. However, cancer cells employ a multitude of mechanisms to mount resistance to amino acid restriction, which impede the latter's clinical development. Here we show that M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3735a193b3ec93f75738d529011799ab
https://doi.org/10.15252/embr.202051436
https://doi.org/10.15252/embr.202051436
Autor:
Ze'ev Ronai, Gaurav Pathria
Publikováno v:
Cell Metab
Sustained proliferative potential of cancer cells creates heightened energetic and biosynthetic demands. The resulting overt dependence of cancer cells on unperturbed nutrient supply, has prompted a wide-spread interest in amino acid restriction stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d491aec7a913dc7f3eba313ed9a66c
https://pubmed.ncbi.nlm.nih.gov/33406406
https://pubmed.ncbi.nlm.nih.gov/33406406