Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gaurav Luthria"'
Autor:
Gaurav Luthria, Ran Li, Stephanie Wang, Mark Prytyskach, Rainer H. Kohler, Douglas A. Lauffenburger, Timothy J. Mitchison, Ralph Weissleder, Miles A. Miller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modula
Externí odkaz:
https://doaj.org/article/6e12c582f93443ddbaa1e7221c686a84
Autor:
Jeremy M. Quintana, David Arboleda, Huiyu Hu, Ella Scott, Gaurav Luthria, Sara Pai, Sareh Parangi, Ralph Weissleder, Miles A. Miller
Publikováno v:
Bioconjugate Chemistry. 33:1474-1484
Conjugation of therapeutic payloads to biologics including antibodies and albumin can enhance the selectively of drug delivery to solid tumors. However, achieving activity in tumors while avoiding healthy tissues remains a challenge, and payload acti
Autor:
Kavita Sarin, Anthony Oro, Jean Yuh Tang, Christina Curtis, Kerri Rieger, Irene Bailey, Kiana Yekrang, Jeanie Ramos, Marlayna Harris, Gaurav Luthria, Gayathri Swaminathan, Audris Chiang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55a5da04d78d34e2a01dbfb25f815de0
https://doi.org/10.26226/m.641999e0b9b42e0013e59220
https://doi.org/10.26226/m.641999e0b9b42e0013e59220
Autor:
Douglas A. Lauffenburger, Stephanie W. Wang, Timothy J. Mitchison, Gaurav Luthria, Rainer H. Kohler, Mark Prytyskach, Miles A. Miller, Ran Li, Ralph Weissleder
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Microtubules (MTs) mediate mitosis, directional signaling, and are therapeutic targets in cancer. Yet in vivo analysis of cancer cell MT behavior within the tumor microenvironment remains challenging. Here we developed an imaging pipeline using plus-
Autor:
Thomas Ng, Douglas A. Lauffenburger, Madeleine J. Oudin, Ralph Weissleder, Mark Prytyskach, Stephanie J. Wang, Ran Li, Rainer H. Kohler, Gaurav Luthria, Miles A. Miller
Publikováno v:
Science Advances
Combining multicellular signaling profiles with in vivo imaging reveals how nanotherapy can block local resistance pathways.
Interpreting how multicellular interactions in the tumor affect resistance pathways to BRAF and MEK1/2 MAPK inhibitors (
Interpreting how multicellular interactions in the tumor affect resistance pathways to BRAF and MEK1/2 MAPK inhibitors (
Autor:
Qingbo Wang, Gaurav Luthria
Publikováno v:
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
PSB
PSB
Clinical trials generate a large amount of data that have been underutilized due to obstacles that prevent data sharing including risking patient privacy, data misrepresentation, and invalid secondary analyses. In order to address these obstacles, we
Publikováno v:
Curr Opin Syst Biol
Forefront techniques for molecular interrogation of mammalian tissues, such as multiplexed tissue imaging, intravital microscopy, and single-cell RNA sequencing (scRNAseq), can combine to quantify cell-type abundance, co-localization, and global leve
Autor:
Miles A, Miller, Hannes, Mikula, Gaurav, Luthria, Ran, Li, Stefan, Kronister, Mark, Prytyskach, Rainer H, Kohler, Timothy, Mitchison, Ralph, Weissleder
Publikováno v:
ACS Nano
Prodrug strategies that facilitate localized and controlled activity of small-molecule therapeutics can reduce systemic exposure and improve pharmacokinetics, yet limitations in activation chemistry have made it difficult to assign tunable multifunct