Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gaurav Jerath"'
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Advancements in systems biology have resulted in the development of network pharmacology, leading to a paradigm shift from “one-target, one-drug” to “target-network, multi-component therapeutics”. We employ a chimeric approach involv
Externí odkaz:
https://doaj.org/article/6f53b632952146e7b40af56c91c87711
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163993 (2016)
Polypeptide chain has an invariant main-chain and a variant side-chain sequence. How the side-chain sequence determines fold in terms of its chemical constitution has been scrutinized extensively and verified periodically. However, a focussed investi
Externí odkaz:
https://doaj.org/article/2e2e18d12d38488e97963b44c1ca75e8
Autor:
Aparna Rai, Gaurav Jerath
Publikováno v:
De Novo Peptide Design ISBN: 9780323999175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50d4d851c1c0c7dc5c39cfd38a7f4b93
https://doi.org/10.1016/b978-0-323-99917-5.00005-6
https://doi.org/10.1016/b978-0-323-99917-5.00005-6
Autor:
Vibin Ramakrishnan, Ruchika Goyal, Aneesh Chandrasekharan, Gaurav Jerath, Yvonne Christian, T. R. Santhosh Kumar
Publikováno v:
Drug Delivery and Translational Research. 12:1285-1292
A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in vitro for cellular uptake and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff60139ce88498150f5c09a98353e504
https://doi.org/10.1007/s13346-021-01035-z
https://doi.org/10.1007/s13346-021-01035-z
Autor:
Gaurav Jerath, Pramod Darvin, Yvonne Christian, Vishal Trivedi, T. R. Santhosh Kumar, Vibin Ramakrishnan
Publikováno v:
Molecular pharmaceutics. 19(8)
The utilization of peptide-based drug delivery systems has been suboptimal due to their poor proteolytic susceptibility, poor cell permeability, and limited tumor homing capabilities. Earlier attempts in using d-enantiomers in peptide sequences incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95e0d7e1ac68c47669ae3e203647455
https://pubmed.ncbi.nlm.nih.gov/35839086
https://pubmed.ncbi.nlm.nih.gov/35839086
Autor:
Debika Datta, Bhupesh Goyal, Deepti Goyal, Ruchika Goyal, Gaurav Jerath, Gaurav Pandey, Kirtikumar Patel, Vivek Prakash, Aparna Rai, Vibin Ramakrishnan, Ranjit Ranbhor, Amay Redkar, Jahnu Saikia, Mouli Sarkar
Publikováno v:
De Novo Peptide Design ISBN: 9780323999175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::586928d7a2319ae319e91f1386a0034f
https://doi.org/10.1016/b978-0-323-99917-5.00012-3
https://doi.org/10.1016/b978-0-323-99917-5.00012-3
Autor:
Gaurav Jerath, Ruchika Goyal, Vibin Ramakrishnan, Vishal Trivedi, Thankayyan R. Santhoshkumar
Publikováno v:
Acta Biomaterialia. 87:130-139
Lack of cell-type specificity and proteolytic susceptibility have long been the major bottlenecks for the development of peptide-based biomaterials for targeted drug delivery. Though a poly-l backbone provides the adaptability to re-conform the pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa25a8c28e64714368833d7a2ad657e
https://doi.org/10.1016/j.actbio.2019.01.036
https://doi.org/10.1016/j.actbio.2019.01.036
Autor:
Ruchika Goyal, Vegi Ganga Modi Naidu, T.R. Santhoshkumar, Gaurav Jerath, Vibin Ramakrishnan, Eswara Rao Puppala, Srikanth Ponneganti, R. Akhil, Aneesh Chandrasekharan, Anupam Sarma
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 333
Poly-peptide molecules have shown promising applications in drug delivery and tumor targeting. A series of tumor homing peptides were designed by exhaustively sampling low energy geometrical basins of amino acids at specific sites of a peptide molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dafcc64fbc4fcd209d4d8376ab561f1
https://pubmed.ncbi.nlm.nih.gov/33722612
https://pubmed.ncbi.nlm.nih.gov/33722612
Autor:
T. R. Santhosh Kumar, Gaurav Jerath, Ruchika Goyal, Vibin Ramakrishnan, Aneesh Chandrasekharan
Publikováno v:
RSC Med Chem
Design of peptide-based targeted delivery vectors with attributes of specificity and selective cellular targeting by fixing their topology and resulting electrostatic fingerprint is the objective of this study. We formulated our peptide design platfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4469ce238f0b695083664005b8f2c777
https://pubmed.ncbi.nlm.nih.gov/34095842
https://pubmed.ncbi.nlm.nih.gov/34095842
Autor:
Gaurav Jerath, Vibin Ramakrishnan, Ruchika Goyal, Thankayyan R. Santhoshkumar, Vishal Trivedi
Publikováno v:
Journal of Peptide Science. 26
Peptides have shown great potential in acting as template for developing versatile carrier platforms in nanomedicine, aimed at selective delivery of drugs to only pathological tissues saving its normal neighbors. Cell-penetrating peptides (CPPs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c82f9688e3f015767288fd46d8f85f
https://doi.org/10.1002/psc.3244
https://doi.org/10.1002/psc.3244