Výsledky vyhledávání - "Gaurav J. Shah"

Automation and interfaces for chemistry and biochemistry in digital microfluidics

Autor: Gaurav J. Shah, Uday Tata, R. Michael van Dam

Publikováno v: TECHNOLOGY. :83-100

Digital microfluidics (DMF) is an emerging technology for manipulation of picoliter to microliter droplets with a wide variety of applications in the fields of chemistry and biochemistry. We review recent developments in input and output interfaces t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b346ba26a059d16751723093f1f7e39
https://doi.org/10.1142/s2339547814300030

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Everolimus in Advanced Pancreatic Neuroendocrine Tumors: The Clinical Experience

Autor: Gaurav J. Shah, James C. Yao, Funda Meric-Bernstam, Alexandria T. Phan, Valentine Jehl

Publikováno v: Cancer Research. 73:1449-1453

The incidence of neuroendocrine tumors (NET) has increased dramatically in the past 30 years. This information has revitalized basic and clinical research into the molecular biology of NET and has resulted in the recent approval of new therapies for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9ce08f3456e9bb971e0318bd30a0be
https://doi.org/10.1158/0008-5472.can-12-3923

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Meniscus-Assisted High-Efficiency Magnetic Collection and Separation for EWOD Droplet Microfluidics

Autor: Gaurav J. Shah, Chang-Jin Kim

Publikováno v: Journal of Microelectromechanical Systems. 18:363-375

This paper describes a technique to increase the efficiency of magnetic concentration on an electrowetting-on-dielectric (EWOD)-based droplet (digital) microfluidic platform operated in air, i.e., on dry surface. Key differences in the force scenario

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ac30a58951cf22db1747b37d7ebd92f
https://doi.org/10.1109/jmems.2009.2013394

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Radiolabelling diverse positron emission tomography (PET) tracers using a single digital microfluidic reactor chip

Autor: Gaurav J. Shah, Supin Chen, Mark Lazari, Jack Lei, Muhammad Rashed Javed, Hee-Kwon Kim, R. Michael van Dam, Pei-Yuin Keng, Chang-Jin Kim

Publikováno v: Chen, S; Javed, MR; Kim, HK; Lei, J; Lazari, M; Shah, GJ; et al.(2014). Radiolabelling diverse positron emission tomography (PET) tracers using a single digital microfluidic reactor chip. Lab on a Chip, 14(5), 902-910. doi: 10.1039/c3lc51195b. UCLA: Retrieved from: http://www.escholarship.org/uc/item/44r9z66x
Lab on a chip, vol 14, iss 5

Radiotracer synthesis is an ideal application for microfluidics because only nanogram quantities are needed for positron emission tomography (PET) imaging. Thousands of radiotracers have been developed in research settings but only a few are readily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d188a48b4d7aecabd1728a330cc93ad0
http://www.escholarship.org/uc/item/44r9z66x

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On-demand droplet loading for automated organic chemistry on digital microfluidics

Autor: R. Michael van Dam, Saman Sadeghi, Huijiang Ding, Supin Chen, Chang-Jin Kim, Gaurav J. Shah

Publikováno v: Shah, GJ; Ding, H; Sadeghi, S; Chen, S; Kim, CJ; & Van Dam, RM. (2013). On-demand droplet loading for automated organic chemistry on digital microfluidics. Lab on a Chip, 13(14), 2785-2795. doi: 10.1039/c3lc41363b. UCLA: Retrieved from: http://www.escholarship.org/uc/item/06t38309
Lab on a chip, vol 13, iss 14

Organic chemistry applications on digital microfluidic devices often involve reagents that are volatile or sensitive and must be introduced to the chip immediately before use. We present a new technique for automated, on-demand loading of ∼1 μL dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1f4d2cda8505e34b87d6099046301d
http://www.escholarship.org/uc/item/06t38309

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On chip droplet characterization: A practical, high-sensitivity measurement of droplet impedance in digital microfluidics

Autor: R. Michael van Dam, Chang-Jin 'Cj' Kim, Huijiang Ding, Supin Chen, Gaurav J. Shah, Pei Yuin Keng, Saman Sadeghi

Publikováno v: Sadeghi, S; Ding, H; Shah, GJ; Chen, S; Keng, PY; Kim, CJCJ; et al.(2012). On chip droplet characterization: A practical, high-sensitivity measurement of droplet impedance in digital microfluidics. Analytical Chemistry, 84(4), 1915-1923. doi: 10.1021/ac202715f. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4tk0p54d
Analytical chemistry, vol 84, iss 4

We demonstrate a new approach to impedance measurement on digital microfluidics chips for the purpose of simple, sensitive, and accurate volume and liquid composition measurement. Adding only a single series resistor to existing AC droplet actuation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1829786f47f7dea1346de07f5d435296
http://www.escholarship.org/uc/item/4tk0p54d

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Micro-chemical synthesis of molecular probes on an electronic microfluidic device

Autor: Huijiang Ding, Arion F. Chatziioannou, Nagichettiar Satyamurthy, Alex A. Dooraghi, Saman Sadeghi, R. Michael van Dam, Chang-Jin 'Cj' Kim, Supin Chen, Gaurav J. Shah, Pei Yuin Keng, Michael E. Phelps

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 109(3)

We have developed an all-electronic digital microfluidic device for microscale chemical synthesis in organic solvents, operated by electrowetting-on-dielectric (EWOD). As an example of the principles, we demonstrate the multistep synthesis of [ 18 F]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab330c1e068a0c429de0bef54349793
https://pubmed.ncbi.nlm.nih.gov/22210110

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Milliliter-to-microliter platform for on-demand loading of aqueous and non-aqueous droplets to digital microfluidics

Autor: Gaurav J. Shah, Huijiang Ding, Supin Chen, Saman Sadeghi, R.M. van Dam, Chang-Jin Kim

Publikováno v: 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference.

We describe a world-to-chip interface for automated, on-demand loading of ∼1µL droplets from a large (∼1mL demonstrated) off-chip reservoir. Utilizing a combination of compressed inert gas and gravity to exert forces on the liquid, the technique

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d941688060a86caf62519750adee2fe
https://doi.org/10.1109/transducers.2011.5969429

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High-Purity Separation of Rare Species in Droplet Microfluidics using Droplet-Conduit Structures

Autor: Chang-Jin Kim, Gaurav J. Shah

Publikováno v: 2009 IEEE 22nd International Conference on Micro Electro Mechanical Systems.

We present a technique to achieve high-purity isolation of the target species in electrowetting-on-dielectric (EWOD)-based droplet microfluidics by forming a long and slender liquid path between droplets that acts as a "conduit" for actively transpor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa17f11416daba1cae63b10452b4ed83
https://doi.org/10.1109/memsys.2009.4805421

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CONCENTRATION OF CD8+ LYMPHOCYTES ON EWOD PLATFORM FOR MONITORING ORGAN TRANSPLANT REJECTION

Autor: Gaurav J. Shah, E.F. Reed, Y. Korin, H.A. Gritsch, J.L. Veale, Chang-Jin Kim

Publikováno v: 2008 Solid-State, Actuators, and Microsystems Workshop Technical Digest.

As important developments in the effort to create a low-power portable lab-on-a-chip system, we demonstrate the concentration of human CD8+ T-lymphocytes on an electrowetting-on-dielectric (EWOD) platform using antibody-conjugated magnetic beads (MB-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fbed5b70c7a4cc94f8afe9bc7000c53
https://doi.org/10.31438/trf.hh2008.8

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