Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gaurav D. Sankhe"'
Autor:
Gaurav D. Sankhe, Rubesh Raja, Devendra Pratap Singh, Sneha Bheemireddy, Subinoy Rana, P. J. Athira, Narendra M. Dixit, Deepak Kumar Saini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Bacterial two-component systems (TCSs) consist of a sensor histidine kinase (HK) that perceives a specific signal, and a cognate response regulator (RR) that modulates the expression of target genes. Positive autoregulation improves TCS sens
Externí odkaz:
https://doaj.org/article/f062305b2f704090bd0e7053941ff8d8
Publikováno v:
mSphere, Vol 3, Iss 3 (2018)
ABSTRACT Two-component signaling systems (TCSs) are central to bacterial adaptation. However, the mechanisms underlying the reactions involving TCS proteins and their reaction rates are largely undetermined. Here, we employed a combined experimental
Externí odkaz:
https://doaj.org/article/75925ace4046453eb8cb4f81f32d8c11
Publikováno v:
eLife, Vol 10 (2021)
Bacterial pathogens that infect phagocytic cells must deploy mechanisms that sense and neutralize host microbicidal effectors. For Mycobacterium tuberculosis, the causative agent of tuberculosis, these mechanisms allow the bacterium to rapidly adapt
Externí odkaz:
https://doaj.org/article/1a5a03298a9343d98fb0356fb5bd5737
Two-component signaling systems (TCSs) in bacteria are often positively auto-regulated, where the histidine kinase (HK) and response regulator (RR) proteins comprising a TCS are expressed downstream of the signal they transduce. This auto-regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8d05ac5e4350ae38bf7e55faad42eca
https://doi.org/10.1101/2021.12.30.474508
https://doi.org/10.1101/2021.12.30.474508
Autor:
Prabhakar Tiwari, Tannu Priya Gosain, Saurabh Chugh, Mamta Singh, Gaurav D. Sankhe, Garima Arora, Saqib Kidwai, Sakshi Agarwal, Deepak K. Saini, Ramandeep Singh
Publikováno v:
Microbial Pathogenesis. 173:105885
Stress adaptation and virulence of various bacterial pathogens require stringent response pathways involving guanosine pentaphosphate and inorganic polyphosphate (PolyP). In M. tuberculosis, intracellular PolyP levels are maintained by the activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f80eefef43a4084620da0eec13cea07
https://doi.org/10.1016/j.micpath.2022.105885
https://doi.org/10.1016/j.micpath.2022.105885
Autor:
Neerupma Bhardwaj, Rambir Singh, Krishna Kumar Singh, Vandana Malhotra, Deepak Kumar Saini, Niveda Udaykumar, Gaurav D. Sankhe
Publikováno v:
Journal of Molecular Biology. 431:777-793
Two-component signal transduction (TCS) cascades involve stimulus-dependent activation and phosphorylation of a sensor kinase (SK), which then transfers the phosphoryl moiety to the response regulator (RR) protein. The fidelity of this phosphotransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbea8a2544b71a86f807978b55990f35
https://doi.org/10.1016/j.jmb.2019.01.004
https://doi.org/10.1016/j.jmb.2019.01.004
Autor:
Nagasuma Chandra, Gaurav D. Sankhe, Devendra Pratap Singh, Vandana Malhotra, Chandrani Thakur, Apoorva Bhatt, Deepak Kumar Saini, Albel Singh, Renu Gopinathan, Rahul Singh Yadav, Vignesh Narayan Hariharan
Publikováno v:
The FASEB Journal. 35
Cell signaling relies on second messengers to transduce signals from the sensory apparatus to downstream signaling pathway components. In bacteria, one of the most important and ubiquitous second messenger is the small molecule cyclic diguanosine mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5507f24fa1c3eeea46932b36679fbe
https://doi.org/10.1096/fj.202002537rr
https://doi.org/10.1096/fj.202002537rr
Publikováno v:
Internet of Things ISBN: 9783030666323
The world is choking due to once-in-a-lifetime pandemic COVID-19 affecting about 9 million people and causing more than 4.5 lakh deaths worldwide and still counting. The causative agent named as SARS-CoV-2 (severe acute respiratory syndrome coronavir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e660035fc419ff76ab960cbdff752e92
https://doi.org/10.1007/978-3-030-66633-0_13
https://doi.org/10.1007/978-3-030-66633-0_13
Publikováno v:
eLife
Bacterial pathogens that infect phagocytic cells must deploy mechanisms that sense and neutralize host microbicidal effectors. For Mycobacterium tuberculosis, the causative agent of tuberculosis, these mechanisms allow the bacterium to rapidly adapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d80e0e669cd5cb6eec9f15c9825599c4
https://pubmed.ncbi.nlm.nih.gov/34003742
https://pubmed.ncbi.nlm.nih.gov/34003742