The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

Autor: Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Madelene Ho, Ghazaleh Eskandari-Sedighi, Chris D. St. Laurent, Kelli A. McCord, Arjun Bains, Gaurav Sidhu, Susmita Sarkar, Jason R. Plemel, Matthew S. Macauley

Publikováno v: Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-22 (2021)

Abstract Background CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an AD-protective CD33 a

Externí odkaz: https://doaj.org/article/9d903e7fcaaf46188f4b75d343f185d2

Additional file 1 of The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

Autor: Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Ho, Madelene, Ghazaleh Eskandari-Sedighi, Laurent, Chris D. St., McCord, Kelli A., Bains, Arjun, Gaurav Sidhu, Sarkar, Susmita, Plemel, Jason R., Macauley, Matthew S.

Additional file 1: Fig. 1. Quantifying microglia in the brain of human CD33 transgenic mice by immunofluorescence staining. The density of microglia was assessed by the number of IBA1 + cells per mm2 of tissue from the average of a minimum of five se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b207ea0928277a907bea1fe975a67dc

Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice.

Autor: Eskandari-Sedighi, Ghazaleh¹ (AUTHOR), Crichton, Madeline¹ (AUTHOR), Zia, Sameera² (AUTHOR), Gomez-Cardona, Erik³ (AUTHOR), Cortez, Leonardo M.^2,4,5 (AUTHOR), Patel, Zain H.⁶ (AUTHOR), Takahashi-Yamashiro, Kei¹ (AUTHOR), St. Laurent, Chris D.¹ (AUTHOR), Sidhu, Gaurav¹ (AUTHOR), Sarkar, Susmita¹ (AUTHOR), Aghanya, Vivian¹ (AUTHOR), Sim, Valerie L.^2,4,5 (AUTHOR), Tan, Qiumin⁶ (AUTHOR), Julien, Olivier^3,5 (AUTHOR), Plemel, Jason R.^2,5,7 (AUTHOR), Macauley, Matthew S.^1,5,7 (AUTHOR) macauley@ualberta.ca

Publikováno v: Molecular Neurodegeneration. 5/27/2024, Vol. 19 Issue 1, p1-27. 27p.

The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia.

Autor: Bhattacherjee, Abhishek¹ (AUTHOR), Jung, Jaesoo¹ (AUTHOR), Zia, Sameera² (AUTHOR), Ho, Madelene² (AUTHOR), Eskandari-Sedighi, Ghazaleh¹ (AUTHOR), St. Laurent, Chris D.¹ (AUTHOR), McCord, Kelli A.¹ (AUTHOR), Bains, Arjun¹ (AUTHOR), Sidhu, Gaurav¹ (AUTHOR), Sarkar, Susmita¹ (AUTHOR), Plemel, Jason R.^2,3 (AUTHOR), Macauley, Matthew S.^1,4 (AUTHOR) macauley@ualberta.ca

Publikováno v: Molecular Neurodegeneration. 3/25/2021, Vol. 16 Issue 1, p1-22. 22p.