Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gaurav, Gadhvi"'
Autor:
Christina L. Bloomfield, Joyce Gong, Steven Droho, Hadijat M. Makinde, Miranda G. Gurra, Cecilia H. Stumpf, Arjun Kharel, Gaurav Gadhvi, Deborah R. Winter, Weiguo Cui, Carla M. Cuda, Jeremy A. Lavine
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionMacrophage function is determined by microenvironment and origin. Brain and retinal microglia are both derived from yolk sac progenitors, yet their microenvironments differ. Utilizing single-cell RNA sequencing (scRNA-seq) data from mice,
Externí odkaz:
https://doaj.org/article/45a0ccb3c3f748c78089ca3719ba45ea
Autor:
Swati Antala, Kyle D. Gromer, Gaurav Gadhvi, Alyssa Kriegermeier, Jiao-Jing Wang, Hiam Abdala-Valencia, Joshua B. Wechsler, Harris Perlman, Deborah R. Winter, Zheng J. Zhang, Richard M. Green, Sarah A. Taylor
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Macrophages (MΦ) play a role in neonatal etiologies of obstructive cholestasis, however, the role for precise MΦ subsets remains poorly defined. We developed a neonatal murine model of bile duct ligation (BDL) to characterize etiology-spec
Externí odkaz:
https://doaj.org/article/eb2124bbc14840b0a30e011ad44439db
Autor:
Anna B. Montgomery, Shang Yang Chen, Yidan Wang, Gaurav Gadhvi, Maximilian G. Mayr, Carla M. Cuda, Salina Dominguez, Hadijat-Kubura Moradeke Makinde, Miranda G. Gurra, Alexander V. Misharin, Arthur M. Mandelin, Eric M. Ruderman, Anjali Thakrar, Simran Brar, Mary Carns, Kathleen Aren, Mahzad Akbarpour, Andrew Filer, Saba Nayar, Ana Teososio, Triin Major, Ankit Bharat, G.R. Scott Budinger, Deborah R. Winter, Harris Perlman
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112513- (2023)
Summary: Monocytes are abundant immune cells that infiltrate inflamed organs. However, the majority of monocyte studies focus on circulating cells, rather than those in tissue. Here, we identify and characterize an intravascular synovial monocyte pop
Externí odkaz:
https://doaj.org/article/adaf60afb9b54ac7aee8d7562ca316cc
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0272166 (2023)
Characterization of gene lists obtained from high-throughput genomic experiments is an essential task to uncover the underlying biological insights. A common strategy is to perform enrichment analyses that utilize standardized biological annotations,
Externí odkaz:
https://doaj.org/article/3002eb51dc7c4bf5851e8ba392caa395
Autor:
Paul A. Reyfman, Elizabeth S. Malsin, Basil Khuder, Nikita Joshi, Gaurav Gadhvi, Annette S. Flozak, Mary A. Carns, Kathleen Aren, Isaac A. Goldberg, Seokjo Kim, Michael Alexander, Peter H. S. Sporn, Alexander V. Misharin, G.R. Scott Budinger, Anna P. Lam, Monique Hinchcliff, Cara J. Gottardi, Deborah R. Winter
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:176-185
Autor:
Hadijat-Kubura M, Makinde, Julia L M, Dunn, Gaurav, Gadhvi, Mary, Carns, Kathleen, Aren, Anh H, Chung, Lutfiyya N, Muhammad, Jing, Song, Carla M, Cuda, Salina, Dominguez, John E, Pandolfino, Jane E, Dematte D'Amico, G Scott, Budinger, Shervin, Assassi, Tracy M, Frech, Dinesh, Khanna, Alex, Shaeffer, Harris, Perlman, Monique, Hinchcliff, Deborah R, Winter, Victoria, Shanmugam
Publikováno v:
Arthritis & Rheumatology. 75:595-608
Patients with diffuse cutaneous systemic sclerosis (dcSSc) display a complex clinical phenotype. Transcriptional profiling of whole blood or tissue from patients are affected by changes in cellular composition that drive gene expression and an inabil
Autor:
Sarah A Taylor, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Kyle D Gromer, Hiam Abdala-Valencia, Kiwon Nam, Salina T Dominguez, Anna B Montgomery, Paul A Reyfman, Lorena Ostilla, Joshua B Wechsler, Carla M Cuda, Richard M Green, Harris Perlman, Deborah R Winter
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244743 (2021)
Background & aimsLimited understanding of the role for specific macrophage subsets in the pathogenesis of cholestatic liver injury is a barrier to advancing medical therapy. Macrophages have previously been implicated in both the mal-adaptive and pro
Externí odkaz:
https://doaj.org/article/c015eb78f3cb4aa88de1330263a1b31d
Autor:
Gal Finer, Yoshiro Maezawa, Shintaro Ide, Tuncer Onay, Tomokazu Souma, Rizaldy Scott, Xiaoyan Liang, Xiangmin Zhao, Gaurav Gadhvi, Deborah R. Winter, Susan E. Quaggin, Tomoko Hayashida
Publikováno v:
Kidney360. 3:1228-1241
Autor:
Paul A, Reyfman, Elizabeth S, Malsin, Basil, Khuder, Nikita, Joshi, Gaurav, Gadhvi, Annette S, Flozak, Mary A, Carns, Kathleen, Aren, Isaac A, Goldberg, Seokjo, Kim, Michael, Alexander, Peter H S, Sporn, Alexander V, Misharin, G R Scott, Budinger, Anna P, Lam, Monique, Hinchcliff, Cara J, Gottardi, Deborah R, Winter
Publikováno v:
American journal of respiratory cell and molecular biology.
Tissue availability remains an important limitation of single-cell genomic technologies for investigating cellular heterogeneity in human health and disease. Bronchoalveolar lavage (BAL) represents a minimally invasive approach to assess an individua
Three Distinct Transcriptional Profiles of Monocytes Associate with Disease Activity in SSc Patients
Autor:
Hadijat-Kubura M. Makinde, Julia L.M. Dunn, Gaurav Gadhvi, Mary Carns, Kathleen Aren, Anh H. Chung, Lutfiyya N. Muhammad, Jing Song, Carla M. Cuda, Salina Dominguez, John E. Pandolfino, Jane E. Dematte D’Amico, G. Scott Budinger, Shervin Assassi, Tracy Frech, Dinesh Khanna, Alex Shaeffer, Harris Perlman, Monique Hinchcliff, Deborah R. Winter
Background/PurposePatients with systemic sclerosis (SSc) display a complex clinical phenotype. There are numerous studies that relate transcriptional signatures from PBMC or whole skin of SSc patients to disease activity. However, analyses of whole t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29c8b1ffcaf3a1afc045d525e2094e6d
https://doi.org/10.1101/2022.01.29.477568
https://doi.org/10.1101/2022.01.29.477568