Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Gaurav, Bedse"'
Publikováno v:
Neurobiology of Stress, Vol 11, Iss , Pp - (2019)
Chronic stress increases the probability of receiving an anxiety, depression, or chronic illness diagnosis. Pharmacological interventions that reduce the behavioral and physiological effects of chronic stress in animal models may represent novel appr
Externí odkaz:
https://doaj.org/article/c5d92f81a3914d4fa193555f8906b360
Autor:
Anandharajan Rathinasabapathy, Alana Horowitz, Kelsey Horton, Ashok Kumar, Santhi Gladson, Thomas Unger, Diana Martinez, Gaurav Bedse, James West, Mohan K. Raizada, Ulrike M. Steckelings, Colin Sumners, Michael J. Katovich, Vinayak Shenoy
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung disease characterized by scar formation and respiratory insufficiency, which progressively leads to death. Pulmonary hypertension (PH) is a common complication of IPF that negatively impacts clini
Externí odkaz:
https://doaj.org/article/903bb2cdf10c4b109344ebe3cc004a44
Publikováno v:
Biol Psychiatry
Over the past decade there has been a surge of interest in the development of endocannabinoid-based therapeutic approaches for the treatment of diverse neuropsychiatric conditions. Although initial preclinical and clinical development efforts focused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0362e51873a1bb6d3d38073ee3b04b
https://doi.org/10.1016/j.biopsych.2020.01.015
https://doi.org/10.1016/j.biopsych.2020.01.015
Autor:
Nathan D. Winters, Cody A. Siciliano, Samuel W. Centanni, Amanda J. Morgan, Snigdha Mukerjee, Philip J. Kingsley, Keenan D Johnson, Anastasia A Astafyev, Gaurav Bedse, Lawrence J. Marnett, Vikrant R. Mahajan, David C. Samuels, Jashim Uddin, Toni A. Patrick, Sachin Patel, Megan Altemus, Danny G. Winder
Publikováno v:
J Clin Invest
Alcohol use disorder (AUD) is associated with substantial morbidity, mortality, and societal cost, and pharmacological treatment options are limited. The endogenous cannabinoid (eCB) signaling system is critically involved in reward processing, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a5a7fe71a64d2350d41fa51a38ae31
https://pubmed.ncbi.nlm.nih.gov/34292886
https://pubmed.ncbi.nlm.nih.gov/34292886
Publikováno v:
Alcohol Clin Exp Res
Alcohol use disorder (AUD) afflicts a large number of individuals, families, and communities globally. Affective disturbances, including stress, depression, and anxiety, are highly comorbid with AUD, contributing in some cases to initial alcohol use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8094625b1ea6cb915a26165cd72996a3
https://doi.org/10.1111/acer.14178
https://doi.org/10.1111/acer.14178
Autor:
Ken Mackie, Nathan D. Winters, James D. Ryan, Eric Delpire, Sachin Patel, Megan Altemus, David J. Marcus, Gaurav Bedse, Andrew D. Gaulden, Luis Eduardo Rosas-Vidal, Francis S. Lee, Veronika Kondev
Publikováno v:
Neuron
Functional coupling between the amygdala and the dorsomedial prefrontal cortex (dmPFC) has been implicated in the generation of negative affective states; however, the mechanisms by which stress increases amygdala-dmPFC synaptic strength and generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa2a84a51a6160bbc861aebc6e80349
https://europepmc.org/articles/PMC7992313/
https://europepmc.org/articles/PMC7992313/
Autor:
Andrew D. Gaulden, Nolan D. Hartley, Md. Jashim Uddin, Toni A. Patrick, Emily Neale, Philip J. Kingsley, Gaurav Bedse, Niels Plath, Lawrence J. Marnett, Sachin Patel
Publikováno v:
Biological Psychiatry. 82:488-499
Background Increasing the available repertoire of effective treatments for mood and anxiety disorders represents a critical unmet need. Pharmacological augmentation of endogenous cannabinoid (eCB) signaling has been suggested to represent a novel app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdead3025dea0f969f37b006061ee2e
https://doi.org/10.1016/j.biopsych.2017.03.002
https://doi.org/10.1016/j.biopsych.2017.03.002
Autor:
Gaurav Bedse, Annalisa Cutrignelli, Antonio Lopalco, Rosa Maria Iacobazzi, Massimo Franco, Cosimo Altomare, Valentino Laquintana, Modesto de Candia, Mara Perrone, Angela Lopedota, Nunzio Denora, Tommaso Cassano
Publikováno v:
Molecular Pharmaceutics. 14:3178-3187
The neurotransmitter dopamine (DA) was covalently linked to oxazepam (OXA), a well-known positive allosteric modulator of γ-aminobutyric acid type-A (GABAA) receptor, through a carbamate linkage (4) or a succinic spacer (6). These conjugates were sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e0d90ed1524bbf7b352d8499241d70
https://doi.org/10.1021/acs.molpharmaceut.7b00405
https://doi.org/10.1021/acs.molpharmaceut.7b00405
Autor:
Dinesh A. Barawkar, Siddhartha De, Yogesh Waman, Ashwinkumar V. Meru, Vidya Ramdas, Kasim A. Mookhtiar, Srinivasa B. Reddy, Sumit Chaudhary, Sujay Basu, Santosh Kumar Madadi, Rhishikesh Thakare, Venkata P. Palle, Anita Chugh, Gaurav Bedse, Summon Koul, Srinivas Rao Chennamaneni, Yogesh D. Shejul, Neela Prasad, Sandhya Chaturvedi, Rajesh Bonagiri, Suraj Menon, Jayasagar Gundu
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:1963-1975
Multipronged approach was used to synthesize a library of diverse C-8 cyclopentyl hypoxanthine analogs from a common intermediate III. Several potent and selective compounds were identified and evaluated for pharmacokinetic (PK) properties in Wistar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b73a7719123cbbcc1c1f7988f5140d8c
https://doi.org/10.1016/j.bmc.2017.02.029
https://doi.org/10.1016/j.bmc.2017.02.029
Autor:
Venkata P. Palle, Dinesh A. Barawkar, Vandna Prasad, Santosh Kumar, Sachin Thorat, Sreekanth R. Rouduri, Sushant Dusange, Yogesh Waman, Arnab Goswami, Anita Chugh, B. Srinivasa Reddy, Kasim A. Mookhtiar, Anil Panmand, Gaurav Bedse, Rajesh Bonagiri, Azfar Quraishi, Vikas Karande, Vidya Ramdas, Meena Patel, Indraneel Ghosh, Rhishikesh Thakre, Sujay Basu, Shalini Paliwal, Dilip Jadhav, Sandhya Chaturvedi, Partha P. Mukhopadhyay, Abhay Kulkarni, Jayasagar Gundu, Suraj Menon
Publikováno v:
European Journal of Medicinal Chemistry. 127:986-996
A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been implicated in lung inflammatory disorders like COPD and asthma. Several potent and selective A2BAd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ed32bbc23dd3e7768f4a309c4f2bc4e
https://doi.org/10.1016/j.ejmech.2016.11.007
https://doi.org/10.1016/j.ejmech.2016.11.007