Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gaurang Jhala"'
Autor:
Prerak Trivedi, Gaurang Jhala, David J. De George, Chris Chiu, Claudia Selck, Tingting Ge, Tara Catterall, Lorraine Elkerbout, Louis Boon, Nicole Joller, Thomas W. Kay, Helen E. Thomas, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChronic activation of self-reactive T cells with beta cell antigens results in the upregulation of immune checkpoint molecules that keep self-reactive T cells under control and delay beta cell destruction in autoimmune diabetes. Inhibitin
Externí odkaz:
https://doaj.org/article/0e2a9e262b5049768e050d08ba434b1c
Autor:
Tingting Ge, Amber‐Lee Phung, Gaurang Jhala, Prerak Trivedi, Nicola Principe, David J De George, Evan G Pappas, Sara Litwak, Laura Sanz‐Villanueva, Tara Catterall, Stacey Fynch, Louis Boon, Thomas W Kay, Jonathan Chee, Balasubramanian Krishnamurthy, Helen E Thomas
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 11, Pp n/a-n/a (2022)
Abstract Objectives Immune checkpoint inhibitors have achieved clinical success in cancer treatment, but this treatment causes immune‐related adverse events, including type 1 diabetes (T1D). Our aim was to test whether a JAK1/JAK2 inhibitor, effect
Externí odkaz:
https://doaj.org/article/2f238a260da54aefb12d7ef799742c6b
Autor:
Mugdha V. Joglekar, Subhshri Sahu, Wilson K.M. Wong, Sarang N. Satoor, Charlotte X. Dong, Ryan J. Farr, Michael D. Williams, Prapti Pandya, Gaurang Jhala, Sundy N.Y. Yang, Yi Vee Chew, Nicola Hetherington, Dhan Thiruchevlam, Sasikala Mitnala, Guduru V. Rao, Duvvuru Nageshwar Reddy, Thomas Loudovaris, Wayne J. Hawthorne, Andrew G. Elefanty, Vinay M. Joglekar, Edouard G. Stanley, David Martin, Helen E. Thomas, David Tosh, Louise T. Dalgaard, Anandwardhan A. Hardikar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1530-1553.e4 (2022)
Background & Aims: Pancreatic islet β-cells are factories for insulin production; however, ectopic expression of insulin also is well recognized. The gallbladder is a next-door neighbor to the developing pancreas. Here, we wanted to understand if ga
Externí odkaz:
https://doaj.org/article/3d728a223a8941f1b6deb7467c5a4e8a
Autor:
Gaurang Jhala, Claudia Selck, Jonathan Chee, Chun-Ting J. Kwong, Evan G. Pappas, Helen E. Thomas, Thomas W.H. Kay, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) mice that spontaneously develop autoimmune diabetes. Mice have two proinsulin genes proinsulin -1 and 2 that are differe
Externí odkaz:
https://doaj.org/article/2e4f4427f77c4d30acd6cfc411dba09c
Autor:
Tingting Ge, Gaurang Jhala, Stacey Fynch, Satoru Akazawa, Sara Litwak, Evan G. Pappas, Tara Catterall, Ishan Vakil, Andrew J. Long, Lisa M. Olson, Balasubramanian Krishnamurthy, Thomas W. Kay, Helen E. Thomas
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, contribute to the destruction of insulin-secreting β cells by CD8+ T cells in type 1 diabetes (T1D). We previously showed that JAK1/JAK
Externí odkaz:
https://doaj.org/article/39354577fa0840eea6c38e144b21a5dd
Autor:
Claudia Selck, Gaurang Jhala, David De George, Chun-Ting J. Kwong, Marie K. Christensen, Evan Pappas, Xin Liu, Tingting Ge, Prerak Trivedi, Axel Kallies, Helen E. Thomas, Thomas W.H. Kay, Balasubramanian Krishnamurthy
Persistent antigen exposure results in the differentiation of functionally impaired, also termed exhausted, T cells which are maintained by a distinct population of precursors of exhausted T (TPEX) cells. T cell exhaustion is well studied in the cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a021ee27d4d282bb2528e974c011c67e
https://doi.org/10.1101/2023.02.12.528226
https://doi.org/10.1101/2023.02.12.528226
Autor:
Helen E. Thomas, Stacey Fynch, Balasubramanian Krishnamurthy, Tara Catterall, Satoru Akazawa, Thomas C. Brodnicki, Kate L. Graham, Claudia Selck, Thomas W.H. Kay, Chun-Ting J. Kwong, Leanne Mackin, Evan G Pappas, Andrew P. R. Sutherland, Gaurang Jhala
Publikováno v:
Diabetologia. 64:878-889
Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in upregulation of type I IFN production in innate immune cells. A type I IFN gene signature seen before the onset of type 1 diabetes has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cfaf809b660ae5a6174b5dc3eb53a74
https://doi.org/10.1007/s00125-020-05378-z
https://doi.org/10.1007/s00125-020-05378-z
Autor:
Gaurang, Jhala, Balasubramanian, Krishnamurthy, Thomas C, Brodnicki, Tingting, Ge, Satoru, Akazawa, Claudia, Selck, Prerak M, Trivedi, Evan G, Pappas, Leanne, Mackin, Nicola, Principe, Erwan, Brémaud, David J, De George, Louis, Boon, Ian, Smyth, Jonathan, Chee, Thomas W H, Kay, Helen E, Thomas
Publikováno v:
Cell reports. 39(4)
Interferon gamma (IFNγ) is a proinflammatory cytokine implicated in autoimmune diseases. However, deficiency or neutralization of IFNγ is ineffective in reducing disease. We characterize islet antigen-specific T cells in non-obese diabetic (NOD) mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97fab22d01f9071dfdfc3f0f26da54e5
https://pubmed.ncbi.nlm.nih.gov/35476975
https://pubmed.ncbi.nlm.nih.gov/35476975
Autor:
Gaurang Jhala, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, TingTing Ge, Satoru Akazawa, Claudia Selck, Prerak M. Trivedi, Evan Pappas, Leanne Mackin, Nicola Principe, Erwan Brémaud, David de George, Louis Boon, Ian Smyth, Jonathan Chee, Thomas William Kay, Helen E. Thomas
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9ab85165831ae3e76cb8fdfe0f88eb7
https://doi.org/10.2139/ssrn.3919948
https://doi.org/10.2139/ssrn.3919948
Autor:
Gaurang Jhala, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, Tingting Ge, Satoru Akazawa, Claudia Selck, Prerak M. Trivedi, Evan G. Pappas, Leanne Mackin, Nicola Principe, Erwan Brémaud, David J. De George, Louis Boon, Ian Smyth, Jonathan Chee, Thomas W.H. Kay, Helen E. Thomas
Publikováno v:
Cell Reports. 39:110747
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::940f280685afe54edca60458f97f81f9
https://doi.org/10.1016/j.celrep.2022.110747
https://doi.org/10.1016/j.celrep.2022.110747