Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels

Autor: Rubaiy, HN, Ludlow, MJ, Henrot, M, Gaunt, HJ, Miteva, K, Cheung, SY, Tanahashi, Y, Hamzah, N, Musialowski, KE, Blythe, NM, Appleby, HL, Bailey, MA, McKeown, L, Taylor, R, Foster, R, Waldmann, H, Nussbaumer, P, Christmann, M, Bon, RS, Muraki, K, Beech, DJ

Publikováno v: The Journal of Biological Chemistry

The concentration of free cytosolic Ca(2+) and the voltage across the plasma membrane are major determinants of cell function. Ca(2+)-permeable non-selective cationic channels are known to regulate these parameters but understanding of these channels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1f997a930b498b96cb147d4631e98d2b

PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.

Autor: Chuntharpursat-Bon E; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK. medechu@leeds.ac.uk., Povstyan OV; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Ludlow MJ; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Carrier DJ; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.; School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK., Debant M; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Shi J; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Gaunt HJ; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Bauer CC; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Curd A; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK., Simon Futers T; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Baxter PD; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Peckham M; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Muench SP; School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Adamson A; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Manchester, M13 9PT, UK., Humphreys N; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Manchester, M13 9PT, UK., Tumova S; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Bon RS; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Cubbon R; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Lichtenstein L; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Beech DJ; School of Medicine, University of Leeds, Leeds, LS2 9JT, UK. d.j.beech@leeds.ac.uk.

Publikováno v: Communications biology [Commun Biol] 2023 Apr 01; Vol. 6 (1), pp. 358. Date of Electronic Publication: 2023 Apr 01.

Rab46 integrates Ca ²⁺ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies.

Autor: Miteva KT; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Pedicini L; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Wilson LA; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Jayasinghe I; Faculty of Biological Sciences, University of Leeds, Leeds, UK., Slip RG; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Marszalek K; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Gaunt HJ; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Bartoli F; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Deivasigamani S; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Sobradillo D; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Beech DJ; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., McKeown L; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK l.mckeown@leeds.ac.uk.

Publikováno v: The Journal of cell biology [J Cell Biol] 2019 Jul 01; Vol. 218 (7), pp. 2232-2246. Date of Electronic Publication: 2019 May 15.

Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin.

Autor: Pedicini L; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Miteva KT; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Hawley V; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Gaunt HJ; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Appleby HL; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Cubbon RM; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Marszalek K; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Kearney MT; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Beech DJ; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., McKeown L; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK. l.mckeown@leeds.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2018 May 15; Vol. 8 (1), pp. 7569. Date of Electronic Publication: 2018 May 15.

Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.

Autor: Webster PJ; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Littlejohns AT; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Gaunt HJ; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Young RS; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Rode B; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Ritchie JE; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Stead LF; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Harrison S; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Droop A; School of Medicine, University of Leeds, Leeds LS2 9JT, UK.; MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS2 9NL, UK., Martin HL; School of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Tomlinson DC; School of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Hyman AJ; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Appleby HL; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Boxall S; School of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., Bruns AF; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Li J; School of Medicine, University of Leeds, Leeds LS2 9JT, UK., Prasad RK; Department of Hepatobiliary and Transplant Surgery, St. James's University Hospital, Leeds LS9 7TF, UK., Lodge JPA; Department of Hepatobiliary and Transplant Surgery, St. James's University Hospital, Leeds LS9 7TF, UK., Burke DA; School of Medicine, University of Leeds, Leeds LS2 9JT, UK.; Department of Colorectal Surgery, St. James's University Hospital, Leeds LS9 7TF, UK., Beech DJ; School of Medicine, University of Leeds, Leeds LS2 9JT, UK.

Publikováno v: Oncotarget [Oncotarget] 2017 Jun 27; Vol. 8 (26), pp. 42288-42299.