IL-22 promotes mucin-type O-glycosylation and MATH1 ⁺ cell-mediated amelioration of intestinal inflammation.

Autor: Singh A; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Beaupre M; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Villegas-Novoa C; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Shiomitsu K; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Gaudino SJ; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Tawch S; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Damle R; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Kempen C; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Choudhury B; GlycoAnalytics Core, University of California, San Diego, La Jolla, CA 92093, USA., McAleer JP; Department of Pharmaceutical Sciences, Marshall University School of Pharmacy, Huntington, WV 25701, USA., Sheridan BS; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Denoya P; Division of Colon and Rectal Surgery, Department of Surgery, Stony Brook University Hospital, Stony Brook, NY 11794, USA., Blumberg RS; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Hearing P; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Allbritton NL; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Kumar P; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: pawan.kumar@stonybrook.edu.

Publikováno v: Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114206. Date of Electronic Publication: 2024 May 11.

IL-17RA-signaling in Lgr5 ⁺ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.

Autor: Lin X; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Gaudino SJ; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Jang KK; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA., Bahadur T; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Singh A; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Banerjee A; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Beaupre M; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Chu T; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Wong HT; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Kim CK; Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Kempen C; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Axelrad J; Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA., Huang H; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Khalid S; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Shah V; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Eskiocak O; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Parks OB; University of Pittsburgh School of Medicine, Medical Scientist Training Program, Pittsburgh, PA 15213, USA., Berisha A; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., McAleer JP; Department of Pharmaceutical Science, Marshall University School of Pharmacy, Huntington, WV 25701, USA., Good M; Washington University School of Medicine, Department of Pediatrics, Division of Newborn Medicine, St. Louis Children's Hospital, St. Louis, MO 63110, USA., Hoshino M; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan., Blumberg R; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Bialkowska AB; Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Gaffen SL; Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Kolls JK; Center for Translational Research in Infection and Inflammation, Tulane School of Medicine, New Orleans, LA 70112, USA., Yang VW; Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Beyaz S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Cadwell K; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA; Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: ken.cadwell@med.nyu.edu., Kumar P; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA. Electronic address: pawan.kumar@stonybrook.edu.

Publikováno v: Immunity [Immunity] 2022 Feb 08; Vol. 55 (2), pp. 237-253.e8. Date of Electronic Publication: 2022 Jan 25.

IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity.

Autor: Gaudino SJ; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Beaupre M; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Lin X; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Joshi P; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Rathi S; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., McLaughlin PA; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Kempen C; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Mehta N; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Eskiocak O; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA., Yueh B; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA., Blumberg RS; Department of Gastroenterology, Brigham and Women's Hospital, Boston, MA, 02115, USA., van der Velden AWM; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Shroyer KR; Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Bialkowska AB; Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Beyaz S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA., Kumar P; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA. pawan.kumar@stonybrook.edu.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2021 Mar; Vol. 14 (2), pp. 389-401. Date of Electronic Publication: 2020 Oct 15.