Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP.

Autor: Hirabayashi Y; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo; Tokyo, 113-8656, Japan., Lewis TL Jr; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA., Du Y; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo; Tokyo, 113-8656, Japan., Virga DM; Department of Biological Sciences, Columbia University; New York, NY, 10027, USA.; Department of Neuroscience, Columbia University; New York, NY, 10027, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University; New York, NY, 10027, USA., Decker AM; Department of Biological Sciences, Columbia University; New York, NY, 10027, USA., Coceano G; Department of Applied Physics and SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden., Alvelid J; Department of Applied Physics and SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.; Department of Biophysical Imaging, Leibniz Institute of Photonic Technology, Jena, Germany., Paul MA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University; New York, NY, 10027, USA.; Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Université PSL; Paris, France., Hamilton S; Department of Neuroscience, Columbia University; New York, NY, 10027, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University; New York, NY, 10027, USA., Kneis P; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA., Takahashi Y; Department of Electronics, Graduate School of Engineering, Nagoya University, 464-8603, Nagoya, Japan.; Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192 Japan., Gaublomme JT; Department of Biological Sciences, Columbia University; New York, NY, 10027, USA., Testa I; Department of Applied Physics and SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden., Polleux F; Department of Neuroscience, Columbia University; New York, NY, 10027, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University; New York, NY, 10027, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 13. Date of Electronic Publication: 2024 Feb 13.

A Roadmap for the Human Gut Cell Atlas.

Autor: Zilbauer M; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. mz304@cam.ac.uk.; University Department of Paediatrics, University of Cambridge, Cambridge, UK. mz304@cam.ac.uk.; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Cambridge, UK. mz304@cam.ac.uk., James KR; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia., Kaur M; School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, South Africa., Pott S; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA., Li Z; Dana-Farber Cancer Institute, Boston, MA, USA., Burger A; Department of Computer Science, Heriot-watt University, Edinburgh, UK., Thiagarajah JR; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Burclaff J; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University', Chapel Hill, NC, USA.; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Jahnsen FL; Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway., Perrone F; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; University Department of Paediatrics, University of Cambridge, Cambridge, UK., Ross AD; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; University Department of Paediatrics, University of Cambridge, Cambridge, UK.; University Department of Medical Genetics, University of Cambridge, Cambridge, UK., Matteoli G; Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Stakenborg N; Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Sujino T; Center for the Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan., Moor A; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Bartolome-Casado R; Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Wellcome Sanger Institute, Hinxton, UK., Bækkevold ES; Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway., Zhou R; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA., Xie B; Department of Medicine, University of Chicago, Chicago, IL, USA., Lau KS; Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Din S; Edinburgh IBD Unit, Western General Hospital, NHS Lothian, Edinburgh, UK., Magness ST; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University', Chapel Hill, NC, USA.; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Yao Q; Department of Computer Science and Engineering, University of Nebraska Lincoln, Lincoln, NE, USA., Beyaz S; Cold Spring Harbour Laboratory, Cold Spring Harbour, New York, NY, USA., Arends M; Division of Pathology, Centre for Comparative Pathology, Cancer Research UK Edinburgh Centre, Institute of Cancer and Genetics, University of Edinburgh, Edinburgh, UK., Denadai-Souza A; Laboratory of Mucosal Biology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Coburn LA; Vanderbilt University Medical Center, Nashville, TN, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA., Gaublomme JT; Department of Biological Sciences, Columbia University, New York, NY, USA., Baldock R; University of Edinburgh, Edinburgh, UK., Papatheodorou I; European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Genome Campus, Hinxton, UK., Ordovas-Montanes J; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Boeckxstaens G; Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Hupalowska A; Genentech, San Francisco, CA, USA., Teichmann SA; Wellcome Sanger Institute, Hinxton, UK.; Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge, UK., Regev A; Genentech, San Francisco, CA, USA.; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Xavier RJ; Broad Institute and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Simmons A; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Snyder MP; Stanford University School of Medicine, Stanford, CA, USA., Wilson KT; Vanderbilt University Medical Center, Nashville, TN, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.

Publikováno v: Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2023 Sep; Vol. 20 (9), pp. 597-614. Date of Electronic Publication: 2023 May 31.

Nuclei multiplexing with barcoded antibodies for single-nucleus genomics.

Autor: Gaublomme JT; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. jellert.gaublomme@columbia.edu.; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA. jellert.gaublomme@columbia.edu., Li B; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA., McCabe C; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Knecht A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Yang Y; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA., Drokhlyansky E; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Van Wittenberghe N; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Waldman J; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Dionne D; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Nguyen L; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., De Jager PL; Center for Translational & Computational Neuroimmunology, Columbia University Medical Center, New York, NY, 10019, USA., Yeung B; BioLegend Inc., San Diego, CA, 92121, USA., Zhao X; BioLegend Inc., San Diego, CA, 92121, USA., Habib N; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, 9190401, Israel., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. orit@broadinstitute.org., Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. aregev@broadinstitute.org.; Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. aregev@broadinstitute.org.

Publikováno v: Nature communications [Nat Commun] 2019 Jul 02; Vol. 10 (1), pp. 2907. Date of Electronic Publication: 2019 Jul 02.

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.

Autor: Gaublomme JT; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA; Department of Physics, Harvard University, 17 Oxford Street, Cambridge, MA 02138, USA., Yosef N; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Lee Y; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Gertner RS; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA; Department of Physics, Harvard University, 17 Oxford Street, Cambridge, MA 02138, USA., Yang LV; Department of Internal Medicine, Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA., Wu C; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Pandolfi PP; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Mak T; Ontario Cancer Center, Princess Margaret Hospital, Toronto, ON M5G 2M9, Canada., Satija R; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; New York Genome Center, New York, NY 10013, USA; Center for Genomics and Systems Biology, New York University, New York, NY 10012, USA., Shalek AK; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Institute for Medical Engineering and Science and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA 02139, USA., Kuchroo VK; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA., Park H; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA; Department of Physics, Harvard University, 17 Oxford Street, Cambridge, MA 02138, USA. Electronic address: hongkun_park@harvard.edu., Regev A; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Howard Hughes Medical Institute and David H. Koch Institute of Integrative Cancer Biology, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: aregev@broadinstitute.org.

Publikováno v: Cell [Cell] 2015 Dec 03; Vol. 163 (6), pp. 1400-12. Date of Electronic Publication: 2015 Nov 19.

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation.

Autor: Shalek AK; 1] Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA [2] Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA [3] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA [4]., Satija R; 1] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA [2]., Shuga J; 1] Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, California 94080, USA [2]., Trombetta JJ; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA., Gennert D; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA., Lu D; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA., Chen P; Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, California 94080, USA., Gertner RS; 1] Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA [2] Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA., Gaublomme JT; 1] Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA [2] Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA., Yosef N; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA., Schwartz S; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA., Fowler B; Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, California 94080, USA., Weaver S; Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, California 94080, USA., Wang J; Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, California 94080, USA., Wang X; Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, California 94080, USA., Ding R; 1] Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA [2] Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA., Raychowdhury R; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA., Friedman N; School of Computer Science and Engineering, Hebrew University, 91904 Jerusalem, Israel., Hacohen N; 1] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Center for Immunology and Inflammatory Diseases & Department of Medicine, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA., Park H; 1] Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA [2] Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA [3] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA., May AP; Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, California 94080, USA., Regev A; 1] Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02140, USA.

Publikováno v: Nature [Nature] 2014 Jun 19; Vol. 510 (7505), pp. 363-9. Date of Electronic Publication: 2014 Jun 11.