Výsledky vyhledávání - "Gatwa Tshinsele-Van Bellingen"

Cas9 off-target binding to the promoter of bacterial genes leads to silencing and toxicity

Autor: William Rostain, Theophile Grebert, Danylo Vyhovskyi, Paula Thiel Pizarro, Gatwa Tshinsele-Van Bellingen, Lun Cui, David Bikard

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2023, 51 (7), pp.3485-3496. ⟨10.1093/nar/gkad170⟩

Genetic tools derived from the Cas9 RNA-guided nuclease are providing essential capabilities to study and engineer bacteria. While the importance of off-target effects was noted early in Cas9’s application to mammalian cells, off-target cleavage by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5a2a90b6a567fdcddb4f2416aa3ddf
https://hal-pasteur.archives-ouvertes.fr/pasteur-04130634/document

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