Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients.

Autor: Panigrahi, Gati K.¹ (AUTHOR), Praharaj, Prakash P.¹ (AUTHOR), Kittaka, Hiroki² (AUTHOR), Mridha, Asit R.¹ (AUTHOR), Black, Olen M.¹ (AUTHOR), Singh, Rakesh³ (AUTHOR), Mercer, Roger³ (AUTHOR), van Bokhoven, Adrie⁴ (AUTHOR), Torkko, Kathleen C.⁴ (AUTHOR), Agarwal, Chapla⁵ (AUTHOR), Agarwal, Rajesh⁵ (AUTHOR), Abd Elmageed, Zakaria Y.⁶ (AUTHOR), Yadav, Hariom⁷ (AUTHOR), Mishra, Santosh K.² (AUTHOR), Deep, Gagan^1,8,9 (AUTHOR) gdeep@wakehealth.edu

Publikováno v: Cancer Medicine. Mar2019, Vol. 8 Issue 3, p1110-1123. 14p.

Exosomes secreted by placental stem cells selectively inhibit growth of aggressive prostate cancer cells

Autor: Prakash Priyadarshi Praharaj, Isabel R. Schlaepfer, Donald J. Vander Griend, Gagan Deep, Michael Doyle, Ravi Singh, Ashok K. Hemal, Anthony Atala, Yixin Su, Julie Alickson, Gati K. Panigrahi, Taylor C. Peak

Publikováno v: Biochemical and Biophysical Research Communications. 499:1004-1010

The current paradigm in the development of new cancer therapies is the ability to target tumor cells while avoiding harm to noncancerous cells. Furthermore, there is a need to develop novel therapeutic options against drug-resistant cancer cells. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9373df2f79a2982cc86bad1d8f947c9c
https://doi.org/10.1016/j.bbrc.2018.04.038

Syntaxin 6-mediated exosome secretion regulates enzalutamide resistance in prostate cancer

Autor: Laura Flores-Bocanegra, Taylor C. Peak, Gati K. Panigrahi, Ravi Singh, Jacqueline Chyr, Nicholas H. Oberlies, Rhonda L. Bitting, Ashok K. Hemal, Lihong Shi, Yixin Su, Bethany A. Kerr, Gagan Deep, José Rivera-Chávez, Prakash Priyadarshi Praharaj, Donald J. Vander Griend

Publikováno v: Mol Carcinog

Prostate cancer (PCa) deaths are typically the result of metastatic castration-resistant PCa (mCRPC). Recently, enzalutamide (Enz), an oral androgen receptor inhibitor, was approved for treating patients with mCRPC. Invariably, all PCa patients event

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bf88d40e22ef574d691bfdac771cd9
https://pubmed.ncbi.nlm.nih.gov/31674708

Exosomes-based biomarker discovery for diagnosis and prognosis of prostate cancer

Autor: Gati K. Panigrahi, Gagan Deep

Publikováno v: Front Biosci (Landmark Ed)

African American men in the United States have higher incidence and mortality rates due to prostate cancer (PCa) compared to other races. In 2016 alone, nearly 30,000 cases of PCa in African American men were diagnosed and 4,450 men died from PCa. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c82acc9d553e7f2087abc6070f9244
https://doi.org/10.2741/4565

Author Correction: Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells

Autor: Ravi Singh, Taylor C. Peak, Gati K. Panigrahi, Gagan Deep, Jessica Long, Johng S. Rhim, Prakash Priyadarshi Praharaj, Zakaria Y. Abd Elmageed

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
Scientific Reports

African American men in the United States have higher mortality due to prostate cancer (PCa) compared to other races. One reason for this disparity is the lack of in-depth understanding of the PCa biology in African Americans. For example, hypoxia in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126f5837c8ac27f547aa1873b845a60a
https://doi.org/10.1038/s41598-018-24997-6