The gateway reflex regulates tissue-specific autoimmune diseases

Autor: Yuki Tanaka, Izuru Ohki, Kaoru Murakami, Satoshi Ozawa, Yaze Wang, Masaaki Murakami

Publikováno v: Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-9 (2024)

Abstract The dynamic interaction and movement of substances and cells between the central nervous system (CNS) and peripheral organs are meticulously controlled by a specialized vascular structure, the blood–brain barrier (BBB). Experimental and cl

Externí odkaz: https://doaj.org/article/9b1971a2a59e4b3b95f12a0fd867602e

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The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels

Autor: Yuki Tanaka, Yasunobu Arima, Daisuke Kamimura, Masaaki Murakami

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

The gateway reflex is a new phenomenon that explains how immune cells bypass the blood–brain barrier to infiltrate the central nervous system (CNS) and trigger neuroinflammation. To date, four examples of gateway reflexes have been discovered, each

Externí odkaz: https://doaj.org/article/603a11cc25f248babf27a276238fffef

Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex

Autor: Andrea Stofkova, Miloslav Zloh, Dominika Andreanska, Ivana Fiserova, Jan Kubovciak, Jan Hejda, Patrik Kutilek, Masaaki Murakami

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 453
International Journal of Molecular Sciences, Vol 23, Iss 453, p 453 (2022)

The gateway reflex is a mechanism by which neural inputs regulate chemokine expression at endothelial cell barriers, thereby establishing gateways for the invasion of autoreactive T cells into barrier-protected tissues. In this study, we hypothesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe11f28314dadbeda1e4c7cc731fc68
https://pubmed.ncbi.nlm.nih.gov/35008877

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