Zobrazeno 1 - 10
of 988
pro vyhledávání: '"Gatenby, Robert"'
Autor:
Phan, Trung V., Li, Shengkai, Howe, Benjamin, Amend, Sarah R., Pienta, Kenneth J., Brown, Joel S., Gatenby, Robert A., Frangakis, Constantine, Austin, Robert H., Keverkidis, Ioannis G.
With the oncologist acting as the ``game leader'', we employ a Stackelberg game-theoretic model involving multiple populations to study prostate cancer. We refine the drug dosing schedule using an empirical Bayes feed-forward analysis, based on clini
Externí odkaz:
http://arxiv.org/abs/2410.16005
Virtually all cells use energy and ion-specific membrane pumps to maintain large transmembrane gradients of Na$^+$, K$^+$, Cl$^-$, Mg$^{++}$, and Ca$^{++}$. Although they consume up to 1/3 of a cell's energy budget, the corresponding evolutionary ben
Externí odkaz:
http://arxiv.org/abs/2312.07977
Autor:
Gatenby, Robert A., Frieden, B. Roy
We propose cells generate large transmembrane ion gradients to form information circuits that detect, process, and respond to environmental perturbations or signals. In this model, the specialized gates of transmembrane ion channels function as infor
Externí odkaz:
http://hdl.handle.net/10150/626193
http://arizona.openrepository.com/arizona/handle/10150/626193
http://arizona.openrepository.com/arizona/handle/10150/626193
Autor:
Wojtkowiak, Jonathan W., Cornnell, Heather C., Matsumoto, Shingo, Saito, Keita, Takakusagi, Yoichi, Dutta, Prasanta, Kim, Munju, Zhang, Xiaomeng, Leos, Rafael, Bailey, Kate M., Martinez, Gary, Lloyd, Mark C., Weber, Craig, Mitchell, James B., Lynch, Ronald M., Baker, Amanda F., Gatenby, Robert A., Rejniak, Katarzyna A., Hart, Charles, Krishna, Murali C., Gillies, Robert J.
BACKGROUND: Hypoxic niches in solid tumors harbor therapy-resistant cells. Hypoxia-activated prodrugs (HAPs) have been designed to overcome this resistance and, to date, have begun to show clinical efficacy. However, clinical HAPs activity could be i
Externí odkaz:
http://hdl.handle.net/10150/610264
http://arizona.openrepository.com/arizona/handle/10150/610264
http://arizona.openrepository.com/arizona/handle/10150/610264
Autor:
Gatenby, Robert, Frieden, B. Roy
Enzymes are proteins that accelerate intracellular chemical reactions often by factors of 10(5) - 10(12)s(-1). We propose the structure and function of enzymes represent the thermodynamic expression of heritable information encoded in DNA with post-t
Externí odkaz:
http://hdl.handle.net/10150/614945
http://arizona.openrepository.com/arizona/handle/10150/614945
http://arizona.openrepository.com/arizona/handle/10150/614945
Publikováno v:
In Seminars in Cancer Biology July 2024 102-103:17-24
Autor:
Strobl, Maximilian A.R., Martin, Alexandra L., West, Jeffrey, Gallaher, Jill, Robertson-Tessi, Mark, Gatenby, Robert, Wenham, Robert, Maini, Philip K., Damaghi, Mehdi, Anderson, Alexander R.A.
Publikováno v:
In Cell Systems 19 June 2024 15(6):510-525
Publikováno v:
In iScience 19 April 2024 27(4)
Publikováno v:
In BBA - Reviews on Cancer March 2024 1879(2)
Integrating experimental data into ecological models plays a central role in understanding biological mechanisms that drive tumor progression where such knowledge can be used to develop new therapeutic strategies. While the current studies emphasize
Externí odkaz:
http://arxiv.org/abs/2104.00079