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pro vyhledávání: '"Gatenby, P."'
Virtually all cells use energy and ion-specific membrane pumps to maintain large transmembrane gradients of Na$^+$, K$^+$, Cl$^-$, Mg$^{++}$, and Ca$^{++}$. Although they consume up to 1/3 of a cell's energy budget, the corresponding evolutionary ben
Externí odkaz:
http://arxiv.org/abs/2312.07977
Autor:
Stefano Pasetto, Michael Montejo, Mohammad U. Zahid, Marilin Rosa, Robert Gatenby, Pirmin Schlicke, Roberto Diaz, Heiko Enderling
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract The reaction-diffusion equation is widely used in mathematical models of cancer. The calibration of model parameters based on limited clinical data is critical to using reaction-diffusion equation simulations for reliable predictions on a pe
Externí odkaz:
https://doaj.org/article/f7f21f5e78774cb288a6cd8f860cfcfc
Autor:
Shaun Robinson, Liam Ring, David Oxborough, Allan Harkness, Sadie Bennett, Bushra Rana, Nilesh Sutaria, Francesco Lo Giudice, Matthew Shun-Shin, Maria Paton, Rae Duncan, James Willis, Claire Colebourn, Gemma Bassindale, Kate Gatenby, Mark Belham, Graham Cole, Daniel Augustine, Otto A. Smiseth
Publikováno v:
Echo Research and Practice, Vol 11, Iss 1, Pp 1-55 (2024)
Abstract Impairment of left ventricular (LV) diastolic function is common amongst those with left heart disease and is associated with significant morbidity. Given that, in simple terms, the ventricle can only eject the volume with which it fills and
Externí odkaz:
https://doaj.org/article/335cf4772eac40f08669af99477f7285
Publikováno v:
BJPsych Open, Vol 10, Pp S166-S166 (2024)
Aims Previous literature has reported that medical students are objectively and subjectively more stressed than the general population. The transition between medical school and commencing a career as a foundation doctor can cause a significant amoun
Externí odkaz:
https://doaj.org/article/3892fd23746441ecbfb733654024b49d
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109614- (2024)
Summary: Virtually all cells use energy-driven, ion-specific membrane pumps to maintain large transmembrane gradients of Na+, K+, Cl−, Mg++, and Ca++, but the corresponding evolutionary benefit remains unclear. We propose that these gradients enabl
Externí odkaz:
https://doaj.org/article/1627842a290049b2abb53d0598fbfec4
Integrating experimental data into ecological models plays a central role in understanding biological mechanisms that drive tumor progression where such knowledge can be used to develop new therapeutic strategies. While the current studies emphasize
Externí odkaz:
http://arxiv.org/abs/2104.00079
Autor:
Jean‐Pascal Capp, Frédéric Thomas, Andriy Marusyk, Antoine M. Dujon, Sophie Tissot, Robert Gatenby, Benjamin Roche, Beata Ujvari, James DeGregori, Joel S. Brown, Aurora M. Nedelcu
Publikováno v:
Evolutionary Applications, Vol 16, Iss 7, Pp 1239-1256 (2023)
Abstract It is traditionally assumed that during cancer development, tumor cells abort their initially cooperative behavior (i.e., cheat) in favor of evolutionary strategies designed solely to enhance their own fitness (i.e., a “selfish” life sty
Externí odkaz:
https://doaj.org/article/40f663a816d647f3bbcfcd57342f99de
Autor:
Anasuya Dighe, Jamie Maziarz, Arig Ibrahim-Hashim, Robert A. Gatenby, Kshitiz, Andre Levchenko, Günter P. Wagner
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108593- (2024)
Summary: Gene expression change is a dominant mode of evolution. Mutations, however, can affect gene expression in multiple cell types. Therefore, gene expression evolution in one cell type can lead to similar gene expression changes in another cell
Externí odkaz:
https://doaj.org/article/448ca9ed8de64c84a2076097d1c4a2ff
Autor:
Ardaševa, Aleksandra, Gatenby, Robert A., Anderson, Alexander R. A., Byrne, Helen M., Maini, Philip K., Lorenzi, Tommaso
Publikováno v:
Phys. Rev. E 102, 042404 (2020)
Deterministic continuum models formulated in terms of non-local partial differential equations for the evolutionary dynamics of populations structured by phenotypic traits have been used recently to address open questions concerning the adaptation of
Externí odkaz:
http://arxiv.org/abs/2004.00914
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