Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

Autor: Webster, SJ, Brode, S, Ellis, L, Fitzmaurice, TJ, Elder, MJ, Gekara, NO, Tourlomousis, P, Bryant, C, Clare, S, Chee, R, Gaston, HJS, Goodall, JC

Publikováno v: PLoS Pathogens, Vol 13, Iss 6, p e1006383 (2017)

The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and noninfectious insult to prevent inappropriate inflammation. Using the impor

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Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection.

Autor: Webster SJ; Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Brode S; Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Ellis L; Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Fitzmaurice TJ; Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Elder MJ; Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Gekara NO; Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, Department of Molecular Biology, Umeå University, Umeå, Sweden., Tourlomousis P; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom., Bryant C; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom., Clare S; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom., Chee R; Department of Immunology, Royal Free Hospital, London, United Kingdom., Gaston HJS; Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Goodall JC; Rheumatology Research Group, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

Publikováno v: PLoS pathogens [PLoS Pathog] 2017 Jun 01; Vol. 13 (6), pp. e1006383. Date of Electronic Publication: 2017 Jun 01 (Print Publication: 2017).