Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gaston H Vondenhoff"'
Autor:
Gaston H Vondenhoff, Ksenia Pugach, Bharat Gadakh, Laurence Carlier, Jef Rozenski, Mathy Froeyen, Konstantin Severinov, Arthur Van Aerschot
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79234 (2013)
Microcin C analogues were recently envisaged as important compounds for the development of novel antibiotics. Two issues that may pose problems to these potential antibiotics are possible acquisition of resistance through acetylation and in vivo inst
Externí odkaz:
https://doaj.org/article/3f70f20bc3884ecfad66def5a2ab4576
Autor:
Vinayak Agarwal, Gaston H. Vondenhoff, Konstantin Severinov, Satish K. Nair, Bharat Gadakh, Arthur Van Aerschot
Publikováno v:
Med. Chem. Commun.. 5:1567-1570
Peptide–nucleotide conjugates have been extensively studied as scaffolds for the development of new antibiotics. However, in vivo, the efficacy of such compounds is limited by various detoxicants, such as aminoacyl-nucleotide hydrolase MccF. MccF c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb97392fda12d4b4ad7435bf106a1fe
https://doi.org/10.1039/c4md00204k
https://doi.org/10.1039/c4md00204k
Publikováno v:
European Journal of Medicinal Chemistry. 46:5227-5236
Increasing resistance to antibiotics is a major problem worldwide and provides the stimulus for development of new bacterial inhibitors with preferably different modes of action. In search for new leads, several new bacterial targets are being exploi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e95f5a88928f6314e398737c3abc7e
https://doi.org/10.1016/j.ejmech.2011.08.049
https://doi.org/10.1016/j.ejmech.2011.08.049
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 30:465-474
The natural compound Microcin C (McC) is a Trojan horse inhibitor of aspartyl tRNA synthetases endowed with strong antibacterial properties, in which a heptapeptide moiety is responsible for active transport of the inhibitory metabolite part into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01117e9526ecf16a024c80139818c447
https://doi.org/10.1080/15257770.2011.583972
https://doi.org/10.1080/15257770.2011.583972
Autor:
Piet Herdewijn, S. Denivelle, Gaston H. Vondenhoff, P. Van de Vijver, Jan Verhaegen, A. Van Aerschot, J. Rozenski
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:260-269
The aminoacyl-tRNA synthetase (aaRS) class of enzymes is a validated target for antimicrobial development. Aminoacyl analogues of 5′- O -( N - l -aminoacyl)-sulfamoyladenosines are known to be potent inhibitors of aaRS, but whole cell antibacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041666a383710fc11847bd8d79ad5e4b
https://doi.org/10.1016/j.bmc.2008.11.054
https://doi.org/10.1016/j.bmc.2008.11.054
Autor:
Arthur Van Aerschot, Ekaterina Semenova, Damir Mukhamedyarov, Konstantin Kuznedelov, Kirill A. Datsenko, Anastasija Metlitskaya, Anton Tikhonov, Satish K. Nair, Vinayak Agarwal, Konstantin Severinov, Gaston H. Vondenhoff, Teymur Kazakov
Publikováno v:
Journal of bacteriology. 196(19)
Peptide-nucleotide antibiotic microcin C (McC) is produced by some Escherichia coli strains. Inside a sensitive cell, McC is processed, releasing a nonhydrolyzable analog of aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase. The product of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47beed39c9b63647843f128f01e8b328
https://pubmed.ncbi.nlm.nih.gov/25002546
https://pubmed.ncbi.nlm.nih.gov/25002546
Base substituted 5 '-O-(N-isoleucyl)sulfamoyl nucleoside analogues as potential antibacterial agents
Autor:
Jef Rozenski, Gaston H. Vondenhoff, Arthur Van Aerschot, Bharat Gadakh, Mathy Froeyen, Eveline Lescrinier
Aminoacyl-sulfamoyl adenosines are well-known nanomolar inhibitors of the corresponding prokaryotic and eukaryotic tRNA synthetases in vitro. Inspired by the aryl-tetrazole containing compounds of Cubist Pharmaceuticals and the modified base as found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c2dddd3da4788b3834a5d83273bbc4
https://lirias.kuleuven.be/handle/123456789/459162
https://lirias.kuleuven.be/handle/123456789/459162
Publikováno v:
Chembiochem : a European journal of chemical biology. 13(13)
In 1998, Cubist Pharmaceuticals patented a series of aminoacyl tRNA synthetase (aaRS) inhibitors based on aminoacyl sulfamoyladenosines (aaSAs), in which the adenine was substituted by aryl-tetrazole moieties linked to the ribose fragment by a two-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ad90d819904f9fbc961aaa64863aea
https://pubmed.ncbi.nlm.nih.gov/22847961
https://pubmed.ncbi.nlm.nih.gov/22847961
Publikováno v:
ChemInform. 43
Increasing resistance to antibiotics is a major problem worldwide and provides the stimulus for development of new bacterial inhibitors with preferably different modes of action. In search for new leads, several new bacterial targets are being exploi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::371b39012b818d97fd4edf7c3449986a
https://doi.org/10.1002/chin.201208270
https://doi.org/10.1002/chin.201208270
Autor:
Arthur Van Aerschot, M. Zhou, Anton Tikhonov, Konstantin Severinov, Keehwan Kwon, Boguslaw Nocek, Gyorgy Babnigg, Minyi Gu, Andrzej Joachimiak, Gaston H. Vondenhoff, Kira S. Makarova, Wayne F. Anderson
Publikováno v:
Journal of molecular biology. 420(4-5)
Microcin C (McC) is heptapeptide adenylate antibiotic produced by Escherichia coli strains carrying the mccABCDEF gene cluster encoding enzymes, in addition to the heptapeptide structural gene mccA, necessary for McC biosynthesis and self-immunity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31503847c0765775919003a05775e22f
https://pubmed.ncbi.nlm.nih.gov/22516613
https://pubmed.ncbi.nlm.nih.gov/22516613