Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Gastón, Soria"'
Autor:
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/c96b11721b9b47a1ac2f8d97e71e0b1f
Autor:
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife, Vol 12 (2023)
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-de
Externí odkaz:
https://doaj.org/article/8d32f189375347eda9d14d8aef197263
Autor:
María C. Llorens de los Ríos, Priscila A. Lanza, Cecilia L. Barbieri, María L. González, Macarena Funes Chabán, Gastón Soria, D. Mariano A. Vera, María C. Carpinella, Mariana B. Joray
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Tumor angiogenesis is considered as a crucial pathologic feature of cancer with a key role in multidrug resistance (MDR). Adverse effects of the currently available drugs and the development of resistance to these remain as the hardest ob
Externí odkaz:
https://doaj.org/article/4d9a0b0bd324440098fc374d3c5cbd8d
Autor:
Consuelo Coronel Arrechea, María Luz Giolito, Iris Alejandra García, Gastón Soria, Javier Valdez Taubas
Publikováno v:
Open Biology, Vol 11, Iss 8 (2021)
Protein S-acylation or palmitoylation is a widespread post-translational modification that consists of the addition of a lipid molecule to cysteine residues of proteins through a thioester bond. Palmitoylation and palmitoyltransferases (PATs) have be
Externí odkaz:
https://doaj.org/article/2f68e1318091427e85f6da5d6a4e5e9e
Autor:
María L. Guantay, Cintia A. Garro, Sebastian Siri, María Pansa, Sonja Ghidelli-Disse, Natalia Paviolo, Ana Racca, Viviana Nicotra, Caius Radu, José L. Bocco, Rosana Felice, Israel Gloger, Marcel Muelbaier, Gerard Drewes, Kevin Madauss, Manuela García, Vanesa Gottifredi, Gastón Soria
Publikováno v:
Cancer Research. 83:P4-08
BRCA2 is a well-established cancer driver in several human malignancies. While the remarkable success of PARP inhibitors proved the clinical potential of targeting BRCA deficiencies, the emergence of resistance mechanisms underscores the importance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92c7c164e79a8dbc7c0ac155eb28d0ee
https://doi.org/10.1158/1538-7445.sabcs22-p4-08-09
https://doi.org/10.1158/1538-7445.sabcs22-p4-08-09
Autor:
Iris A. García, Maria Florencia Pansa, Adriana Del Valle Pacciaroni, Manuela E. García, Maria Laura Gonzalez, Juan Carlos Oberti, José Luís Bocco, Maria Cecilia Carpinella, Gloria E. Barboza, Viviana E. Nicotra, Gastón Soria
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Several plants from South America show strong antitumoral properties based on anti-proliferative and/or pro-apoptotic activities. In this work we aimed to identify selective cytotoxic compounds that target BRCA1-deficient cancer cells by Synthetic Le
Externí odkaz:
https://doaj.org/article/0ce6284b1bf7492eb3faf577a23a41b9
Autor:
Soledad Stagnoli, Cintia Garro, Ozlem Ertekin, Susanne Heid, Stefan Seyferth, Gastón Soria, N. Mariano Correa, Aldo Leal-Egaña, Aldo R. Boccaccini
Publikováno v:
Journal of Colloid and Interface Science. 629:1066-1080
The efficacy of chemotherapeutic procedures relies on delivering proper concentrations of anti-cancer drugs in the tumor surroundings, so as to prevent potential side effects on healthy tissues. Novel drug carrier platforms should not just be able to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907e0f8da255f44d5b1caa10c5751b18
https://doi.org/10.1016/j.jcis.2022.08.163
https://doi.org/10.1016/j.jcis.2022.08.163
Autor:
Natalia Soledad Paviolo, María Belén de la Vega, María Florencia Pansa, Iris Alejandra García, Nicolás Luis Calzetta, Gastón Soria, Vanesa Gottifredi
Publikováno v:
Genetics and Molecular Biology, Vol 43, Iss 1 suppl 1 (2019)
Abstract The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired double strand b
Externí odkaz:
https://doaj.org/article/afb09438748741158b7b51590b60777d
Autor:
María Candelaria Llorens, Fabiana Alejandra Rossi, Iris Alejandra García, Mariana Cooke, Martin C. Abba, Cynthia Lopez-Haber, Laura Barrio-Real, María Victoria Vaglienti, Mario Rossi, José Luis Bocco, Marcelo G. Kazanietz, Gastón Soria
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
ZEB1 is a master regulator of the Epithelial-to-Mesenchymal Transition (EMT) program. While extensive evidence confirmed the importance of ZEB1 as an EMT transcription factor that promotes tumor invasiveness and metastasis, little is known about its
Externí odkaz:
https://doaj.org/article/ea4079824ca24cf1999973aeca05bf3b
Autor:
Maria Eugenia Sabatino, Andrés Castellaro, Ana C. Racca, Sofía Carbajosa González, Maria Florencia Pansa, Gastón Soria, Jose Luis Bocco
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Krüppel-like factor 6 (KLF6) is a transcription factor involved in the regulation of several cellular processes. Regarding its role in tumorigenesis, KLF6 is considered a tumor suppressor. Numerous reports demonstrate its frequent genomic loss or do
Externí odkaz:
https://doaj.org/article/f88210b449a348e6978d7bb003bfd45e