Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Gaspar-Maia A"'
Autor:
Carli M. Stewart, Elizabeth L. Siegler, R. Leo Sakemura, Michelle J. Cox, Truc Huynh, Brooke Kimball, Long Mai, Ismail Can, Claudia Manriquez Roman, Kun Yun, Olivia Sirpilla, James H. Girsch, Ekene Ogbodo, Wazim Mohammed Ismail, Alexandre Gaspar-Maia, Justin Budka, Jenny Kim, Nathalie Scholler, Mike Mattie, Simone Filosto, Saad S. Kenderian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Durable response to chimeric antigen receptor T (CART) cell therapy remains limited in part due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion with three independent approaches including: a genome-wide C
Externí odkaz:
https://doaj.org/article/9385e305f428439ba7536b1503dee2fa
Autor:
Dong-Gi Mun, Firdous A. Bhat, Neha Joshi, Leticia Sandoval, Husheng Ding, Anu Jain, Jane A. Peterson, Taewook Kang, Ganesh P. Pujari, Jennifer L. Tomlinson, Rohit Budhraja, Roman M. Zenka, Nagarajan Kannan, Benjamin R. Kipp, Surendra Dasari, Alexandre Gaspar-Maia, Rory L. Smoot, Richard K. Kandasamy, Akhilesh Pandey
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract The rapid evolution of mass spectrometry-based single-cell proteomics now enables the cataloging of several thousand proteins from single cells. We investigated whether we could discover cellular heterogeneity beyond proteome, encompassing p
Externí odkaz:
https://doaj.org/article/41f4506afb6741688f7c4f83231b9391
Autor:
Daheui Choi, Alan M. Gonzalez‐Suarez, Mihai G. Dumbrava, Michael Medlyn, Jose M. deHoyos‐Vega, Frank Cichocki, Jeffrey S. Miller, Li Ding, Mojun Zhu, Gulnaz Stybayeva, Alexandre Gaspar‐Maia, Daniel D. Billadeau, Wen Wee Ma, Alexander Revzin
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract Patient‐derived cancer organoids (PDOs) hold considerable promise for personalizing therapy selection and improving patient outcomes. However, it is challenging to generate PDOs in sufficient numbers to test therapies in standard culture p
Externí odkaz:
https://doaj.org/article/8bace5ec4db746318ee3c8614e155c51
Akademický článek
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Autor:
Wazim Mohammed Ismail, Amelia Mazzone, Flavia G. Ghiraldini, Jagneet Kaur, Manvir Bains, Amik Munankarmy, Monique S. Bagwell, Stephanie L. Safgren, John Moore-Weiss, Marina Buciuc, Lynzie Shimp, Kelsey A. Leach, Luis F. Duarte, Chandandeep S. Nagi, Saul Carcamo, Chi-Yeh Chung, Dan Hasson, Neda Dadgar, Jian Zhong, Jeong-Heon Lee, Fergus J. Couch, Alexander Revzin, Tamas Ordog, Emily Bernstein, Alexandre Gaspar-Maia
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
MacroH2A histone variants are shown to mark a subset of enhancers in both normal and cancer cells. In mice, macroH2A deficiency is shown to facilitate increased activity of transcription stem cell-associated transcription factors.
Externí odkaz:
https://doaj.org/article/687c1bfb1c8f4aa091d8d2f3ab0a9055
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Moritz Binder, Liguo Wang, Stephanie Safgren, Jeong-Heon Lee, Terra Lasho, Christy Finke, Jenna Fernandez, Abhishek Mangaonkar, Alexandre Gaspar-Maia, Mrinal Patnaik
Publikováno v:
HemaSphere, Vol 7, p e5593144 (2023)
Externí odkaz:
https://doaj.org/article/3d3f1971d355479cba3c179bd5f0cb97
Autor:
Moritz Binder, Ryan M. Carr, Terra L. Lasho, Christy M. Finke, Abhishek A. Mangaonkar, Christopher L. Pin, Kurt R. Berger, Amelia Mazzone, Sandeep Potluri, Tamas Ordog, Keith D. Robertson, David L. Marks, Martin E. Fernandez-Zapico, Alexandre Gaspar-Maia, Mrinal M. Patnaik
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
‘Mutations in the chromatin remodeler ASXL1 (ASXL1MT) are associated with poor clinical outcome, however, their impact on chromatin dynamics remains unexplored. Here the authors use a multi-omics approach for chronic myelomonocytic leukemia (CMML)
Externí odkaz:
https://doaj.org/article/81870b2649874a6f8f41f85549083775
Autor:
Stewart, Carli M., Siegler, Elizabeth L., Sakemura, R. Leo, Cox, Michelle J., Huynh, Truc, Kimball, Brooke, Mai, Long, Can, Ismail, Manriquez Roman, Claudia, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Ogbodo, Ekene, Mohammed Ismail, Wazim, Gaspar-Maia, Alexandre, Budka, Justin, Kim, Jenny, Scholler, Nathalie, Mattie, Mike, Filosto, Simone
Publikováno v:
Nature Communications; 9/12/2024, Vol. 15 Issue 1, p1-17, 17p
Autor:
Celestia Fang, Zhenjia Wang, Cuijuan Han, Stephanie L. Safgren, Kathryn A. Helmin, Emmalee R. Adelman, Valentina Serafin, Giuseppe Basso, Kyle P. Eagen, Alexandre Gaspar-Maia, Maria E. Figueroa, Benjamin D. Singer, Aakrosh Ratan, Panagiotis Ntziachristos, Chongzhi Zang
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-30 (2020)
Abstract Background The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding
Externí odkaz:
https://doaj.org/article/201a149ebc41420fb2d70ed374836a5e