Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gaspar P Pinto"'
Autor:
Andrea Schenkmayerova, Gaspar P. Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Daniel Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Dörr, Radka Chaloupkova, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T. Bornscheuer, Jiri Damborsky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Directed evolution commonly relies on point mutations but InDels frequently occur in evolution. Here the authors report a protein-engineering framework based on InDel mutagenesis and fragment transplantation resulting in greater catalysis and longer
Externí odkaz:
https://doaj.org/article/3c18b7a5373d42f0b49ea5eb1b1dcbad
Autor:
Gaspar P. Pinto, Ondrej Vavra, Sergio M. Marques, Jiri Filipovic, David Bednar, Jiri Damborsky
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3187-3197 (2021)
The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes pathological pulmonary symptoms. Most efforts to develop vaccines and drugs against this virus target the spike glycoprotein, particularly its S1 subunit, which is recognised
Externí odkaz:
https://doaj.org/article/93b28a43261b4e2fb2587c3f9e6649f4
Autor:
Piia Kokkonen, Michaela Slanska, Veronika Dockalova, Gaspar P. Pinto, Esther M. Sánchez-Carnerero, Jiri Damborsky, Petr Klán, Zbynek Prokop, David Bednar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 805-813 (2020)
Transport of ligands between bulk solvent and the buried active sites is a critical event in the catalytic cycle of many enzymes. The rational design of transport pathways is far from trivial due to the lack of knowledge about the effect of mutations
Externí odkaz:
https://doaj.org/article/493aafb59e9347a1a3cfbd8d85f9384d
Autor:
Andrea Schenkmayerova, Martin Toul, Daniel Pluskal, Racha Baatallah, Glwadys Gagnot, Gaspar P. Pinto, Vinicius T. Santana, Marketa Stuchla, Petr Neugebauer, Pimchai Chaiyen, Jiri Damborsky, David Bednar, Yves L. Janin, Zbynek Prokop, Martin Marek
Publikováno v:
Nature Catalysis. 6:23-38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20ece5f2cbeec610f609c4f7ebba5547
https://doi.org/10.1038/s41929-022-00895-z
https://doi.org/10.1038/s41929-022-00895-z
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Transcription and translation are fundamental cellular processes that govern the protein production of cells. These processes are generally up regulated in cancer cells, to maintain the enhanced metabolism and proliferative state of these cells. As s
Externí odkaz:
https://doaj.org/article/9cbabb701c994a078d5192007dfb2399
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Protein tunnels and channels are attractive targets for drug design. Drug molecules that block the access of substrates or release of products can be efficient modulators of biological activity. Here, we demonstrate the applicability of a newly devel
Externí odkaz:
https://doaj.org/article/ea3750d1ca4041ce86e094f53dac33b2
Publikováno v:
Nature Reviews Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14f153a40ba7817d8dcc224bb38fe147
https://doi.org/10.1038/s41570-023-00495-w
https://doi.org/10.1038/s41570-023-00495-w
Akademický článek
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Autor:
Joan Planas-Iglesias, Filip Opaleny, Pavol Ulbrich, Jan Stourac, Zainab Sanusi, Gaspar P Pinto, Andrea Schenkmayerova, Jan Byska, Jiri Damborsky, Barbora Kozlikova, David Bednar
Publikováno v:
Nucleic acids research
The transplantation of loops between structurally related proteins is a compelling method to improve the activity, specificity and stability of enzymes. However, despite the interest of loop regions in protein engineering, the available methods of lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdd029ea8d5a4a2e7dafc4599807b1c
https://pubmed.ncbi.nlm.nih.gov/35438789
https://pubmed.ncbi.nlm.nih.gov/35438789
Autor:
Andrea Schenkmayerova, Martin Toul, Daniel Pluskal, Racha Baatallah, Glwadys Gagnot, Gaspar P. Pinto, Vinicius T. Santana, Marketa Stuchla, Petr Neugebauer, Pimchai Chaiyen, Jiri Damborsky, David Bednar, Yves L. Janin, Zbynek Prokop, Martin Marek
The widely used coelenterazine-powered Renilla luciferase was discovered over 40 years ago but the oxidative mechanism by which it generates blue photons remains unclear. Here we decipher Renilla-type bioluminescence through crystallographic, spectro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d06a2f7a8e1b60a2082bbb00cbf9554
https://doi.org/10.1101/2022.02.09.479090
https://doi.org/10.1101/2022.02.09.479090
