Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Gaspar J. Kitange"'
Autor:
Bryan G. Harder, Sen Peng, Christopher P. Sereduk, Andrej M. Sodoma, Gaspar J. Kitange, Joseph C. Loftus, Jann N. Sarkaria, Nhan L. Tran
Publikováno v:
Molecular Medicine, Vol 25, Iss 1, Pp 1-11 (2019)
Abstract Background Temozolomide (TMZ) is the most commonly used chemotherapeutic agent used to treat glioblastoma (GBM), which causes significant DNA damage to highly proliferative cells. Our observations have added to accumulating evidence that TMZ
Externí odkaz:
https://doaj.org/article/11a55e0d187447f9ad9dbba577300d4d
Autor:
Xiaoyue Chen, Minjie Zhang, Haiyun Gan, Heping Wang, Jeong-Heon Lee, Dong Fang, Gaspar J. Kitange, Lihong He, Zeng Hu, Ian F. Parney, Fredric B. Meyer, Caterina Giannini, Jann N. Sarkaria, Zhiguo Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Temozolomide (TMZ) resistance in glioblastomas (GBM) is associated with increased MGMT expression. Here, the authors identify an enhancer between the promoters of MKI67 and MGMT, that when activated drives MGMT expression despite MGMT promoter methyl
Externí odkaz:
https://doaj.org/article/e9cbaa57340b40429d4d685a036a322c
Autor:
Shiv K. Gupta, Emily J. Smith, Ann C. Mladek, Shulan Tian, Paul A. Decker, Sani H. Kizilbash, Gaspar J. Kitange, Jann N. Sarkaria
Publikováno v:
Frontiers in Oncology, Vol 8 (2019)
Prognosis of patients with glioblastoma (GBM) remains dismal despite maximal surgical resection followed by aggressive chemo-radiation therapy. Almost every GBM, regardless of genotype, relapses as aggressive recurrent disease. Sensitization of GBM c
Externí odkaz:
https://doaj.org/article/aadda5d7499241cebbf1b673ba724aab
Autor:
Gaspar J. Kitange, Ann C. Mladek, Mark A. Schroeder, Jenny C. Pokorny, Brett L. Carlson, Yuji Zhang, Asha A. Nair, Jeong-Heon Lee, Huihuang Yan, Paul A. Decker, Zhiguo Zhang, Jann N. Sarkaria
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2587-2598 (2016)
Here we provide evidence that RBBP4 modulates temozolomide (TMZ) sensitivity through coordinate regulation of two key DNA repair genes critical for recovery from TMZ-induced DNA damage: methylguanine-DNA-methyltransferase (MGMT) and RAD51. Disruption
Externí odkaz:
https://doaj.org/article/8e14b685c3304c7fa147e80847088793
Autor:
Jann N. Sarkaria, William F. Elmquist, Andrew A. Protter, Ying Feng, Yuqiao Shen, Gaspar J. Kitange, Paul A. Decker, Mark A. Schroeder, Ann C. Mladek, Katrina K. Bakken, Brett L. Carlson, Karen E. Parrish, Ryo Kawashima, Kenneth Chang, Shiv K. Gupta, Sani H. Kizilbash
Evaluation of sensitizing effects of TAL in GBM cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37be1fdfda968d46ee4b4d22cb01bc32
https://doi.org/10.1158/1535-7163.22505305.v1
https://doi.org/10.1158/1535-7163.22505305.v1
Autor:
Jann N. Sarkaria, William F. Elmquist, Andrew A. Protter, Ying Feng, Yuqiao Shen, Gaspar J. Kitange, Paul A. Decker, Mark A. Schroeder, Ann C. Mladek, Katrina K. Bakken, Brett L. Carlson, Karen E. Parrish, Ryo Kawashima, Kenneth Chang, Shiv K. Gupta, Sani H. Kizilbash
Supplementary methods and Captions to the Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1dd961369700b863b7c74aa06bee26
https://doi.org/10.1158/1535-7163.22505281.v1
https://doi.org/10.1158/1535-7163.22505281.v1
Autor:
Jann N. Sarkaria, William F. Elmquist, Andrew A. Protter, Ying Feng, Yuqiao Shen, Gaspar J. Kitange, Paul A. Decker, Mark A. Schroeder, Ann C. Mladek, Katrina K. Bakken, Brett L. Carlson, Karen E. Parrish, Ryo Kawashima, Kenneth Chang, Shiv K. Gupta, Sani H. Kizilbash
Poly ADP-ribose polymerase (PARP) inhibitors, including talazoparib, potentiate temozolomide efficacy in multiple tumor types; however, talazoparib-mediated sensitization has not been evaluated in orthotopic glioblastoma (GBM) models. This study eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::610fead5e240273df4c9b17631c87d5c
https://doi.org/10.1158/1535-7163.c.6538018.v1
https://doi.org/10.1158/1535-7163.c.6538018.v1
Autor:
Jann N. Sarkaria, William F. Elmquist, Nathalie Y.R. Agar, Panos Z. Anastasiadis, Ian F. Parney, Aaron J. Johnson, Gaspar J. Kitange, Jeanette E. Eckel-Passow, Paul A Decker, Shulan Tian, James Watters, Laurent Debussche, Cedric Barriere, Fang Jin, Karen E. Parrish, Ann C. Mladek, Isabelle Meaux, Rachael A. Vaubel, Ryan W. Feathers, Shuangling Zhang, David Calligaris, Daniel J. Ma, Minjee Kim
Fig. S1: MDM2 transcript expression. RNA extracted from flank tumor xenografts from 51 PDX models was assessed by qRT-PCR for MDM2 expression in pooled triplicate samples and compared to expression in normal brain (NB). Fig. S2: MDM2 Amplification in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4d4bccac2b614bb5347cc66708c7b1
https://doi.org/10.1158/1535-7163.22505115
https://doi.org/10.1158/1535-7163.22505115
Autor:
Jann N. Sarkaria, William F. Elmquist, Nathalie Y.R. Agar, Panos Z. Anastasiadis, Ian F. Parney, Aaron J. Johnson, Gaspar J. Kitange, Jeanette E. Eckel-Passow, Paul A Decker, Shulan Tian, James Watters, Laurent Debussche, Cedric Barriere, Fang Jin, Karen E. Parrish, Ann C. Mladek, Isabelle Meaux, Rachael A. Vaubel, Ryan W. Feathers, Shuangling Zhang, David Calligaris, Daniel J. Ma, Minjee Kim
Controversy exists surrounding whether heterogeneous disruption of the blood–brain barrier (BBB), as seen in glioblastoma (GBM), leads to adequate drug delivery sufficient for efficacy in GBM. This question is especially important when using potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1456b2133a588e38554e1ad333e22fed
https://doi.org/10.1158/1535-7163.c.6537957.v1
https://doi.org/10.1158/1535-7163.c.6537957.v1
Autor:
Jann N. Sarkaria, Ian F. Parney, Robert B. Jenkins, Caterina Giannini, Nhan L. Tran, Brian P. O'Neill, Fredrick B. Meyer, Terry C. Burns, Erik P. Sulman, Roel G. Verhaak, Jeanette E. Eckel-Passow, Daniel H. LaChance, Andrea Califano, Eric W. Klee, Bianca M. Marin, Qianghu Wang, Michael E. Berens, Harshil D. Dhruv, Huihuang Yan, Paul A. Decker, Lisa Evers, Gobinda Sarkar, Daniel J. Ma, Brett L. Carlson, Sen Peng, Rebecca Grove, Thomas M. Kollmeyer, Alissa Caron, Gaspar J. Kitange, Ann C. Mladek, Mark A. Schroeder, Dioval Remonde, Shulan Tian, Rachael A. Vaubel
Genetics of recurrent PDX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a9c1b2dc946e2a7e9fe8b874f98133
https://doi.org/10.1158/1078-0432.22473342
https://doi.org/10.1158/1078-0432.22473342