Regulation of GTPase function by autophosphorylation

Autor: KleinJan F, Gasmi-Seabrook Gmc, Kijun Song, Lakhani J, Ezekiel A. Geffken, Christian W. Johnson, Christopher B. Marshall, Teklab Gebregiworgis, Joao A. Paulo, Olesja Popow, Hyuk-Soo Seo, Kevin M. Haigis, Elizabeth M. Terrell, Deborah K. Morrison, Mitsuhiko Ikura, Carla Mattos, Andrew Bo Liu, Sirano Dhe-Paganon

SUMMARYA unifying feature of the RAS superfamily is a functionally conserved GTPase cycle that proteins use to transition between active and inactive states. Here, we demonstrate that active site autophosphorylation of some small GTPases is an intrin

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https://doi.org/10.1101/2021.06.23.449327

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Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3.

Autor: Saitoh T; Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Hokkaido, 006-8585, Japan; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada. Electronic address: saito-t@hus.ac.jp., Kim HN; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada., Narita R; Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Hokkaido, 006-8585, Japan., Ohtsuka I; Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Hokkaido, 006-8585, Japan., Mo W; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada., Lee KY; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada., Enomoto M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada., Gasmi-Seabrook GMC; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada., Marshall CB; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada. Electronic address: Chris.Marshall@uhnresearch.ca., Ikura M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 1L7, Canada. Electronic address: Mitsu.Ikura@uhnresearch.ca.

Publikováno v: Protein expression and purification [Protein Expr Purif] 2023 Dec; Vol. 212, pp. 106361. Date of Electronic Publication: 2023 Aug 29.

Regulation of GTPase function by autophosphorylation.

Autor: Johnson CW; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Seo HS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Terrell EM; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA., Yang MH; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., KleinJan F; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Gebregiworgis T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Gasmi-Seabrook GMC; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Geffken EA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Lakhani J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Song K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Bashyal P; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Popow O; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Liu A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Mattos C; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA., Marshall CB; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Ikura M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Morrison DK; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA., Dhe-Paganon S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Haigis KM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: Kevin_Haigis@dfci.harvard.edu.

Publikováno v: Molecular cell [Mol Cell] 2022 Mar 03; Vol. 82 (5), pp. 950-968.e14. Date of Electronic Publication: 2022 Feb 23.

NMR in integrated biophysical drug discovery for RAS: past, present, and future.

Autor: Marshall CB; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada. Chris.Marshall@uhnresearch.ca., KleinJan F; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada., Gebregiworgis T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada., Lee KY; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada., Fang Z; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada., Eves BJ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada., Liu NF; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada., Gasmi-Seabrook GMC; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada., Enomoto M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada., Ikura M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada. Mitsu.Ikura@uhnresearch.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada. Mitsu.Ikura@uhnresearch.ca.

Publikováno v: Journal of biomolecular NMR [J Biomol NMR] 2020 Nov; Vol. 74 (10-11), pp. 531-554. Date of Electronic Publication: 2020 Aug 17.