Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

Autor: Budinsky, R. A., Schrenk, D., Simon, T., Van Den Berg, M., Reichard, J. F., Silkworth, J. B., Aylward, L. L., Brix, A., Gasiewicz, T., Kaminski, N., Perdew, G., Starr, T. B., Walker, N. J., Rowlands, J. C., LS IRAS Tox Algemeen, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA1

Publikováno v: Critical Reviews in Toxicology, 44(1), 83. Informa Healthcare

Dioxins and dioxin-like compounds are tumor promoters that cause liver cancer in rats and mice. The aryl hydrocarbon receptor (AHR) has been implicated as a key component in this tumor promotion response. Despite extensive knowledge of the toxicology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbac01edd5de018239ac18588259edf6
https://dspace.library.uu.nl/handle/1874/305011

Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2a/C-MYC axis under hypoxia

Autor: Zhai, W, Sun, Y, Jiang, M, Wang, M, Gasiewicz, T A, Zheng, J, Chang, C

Publikováno v: Oncogene; September 2016, Vol. 35 Issue: 37 p4866-4880, 15p

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The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts.

Autor: Martey, C. A., Baglole, C. J., Gasiewicz, T. A., Sime, P. J., Phipps, R. P.

Publikováno v: American Journal of Physiology: Lung Cellular & Molecular Physiology; Sep2005, Vol. 289, pL391-L399, 9p, 10 Color Photographs, 9 Black and White Photographs, 1 Graph

The Toxicokinetics of 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin in Mammalian Systems.

Autor: Neal, R. A., Olson, J. R., Gasiewicz, T. A., Geiger, L. E.

Publikováno v: Drug Metabolism Reviews; 1982, Vol. 13 Issue 3, p355-385, 31p