Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gary X. Shaw"'
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 908-915 (2022)
The RNase III family of dsRNA-specific endonucleases is exemplified by prokaryotic RNase III and eukaryotic Rnt1p, Drosha, and Dicer. Structures of Aquifex aeolicus RNase III (AaRNase III) and Saccharomyces cerevisiae Rnt1p (ScRnt1p) show that both e
Externí odkaz:
https://doaj.org/article/17267a72f687440eb37fb912c4cc86e8
Publikováno v:
Current Research in Structural Biology, Vol 5, Iss , Pp 100095- (2023)
Dihydroneopterin aldolase (DHNA) is essential for folate biosynthesis in microorganisms. Without a counterpart in mammals, DHNA is an attractive target for antimicrobial agents. Helicobacter pylori infection occurs in human stomach of over 50% of the
Externí odkaz:
https://doaj.org/article/60527449d7c541a6b156266368e98bd5
Autor:
Scott Cherry, Xinhua Ji, He Song, Ding J. Jin, Madushini N. Dharmasena, Gary X. Shaw, Chao Wang, Joseph E. Tropea
Publikováno v:
FEBS J
Rapid adaptation to environmental changes is crucial for bacterial survival. Almost all bacteria possess a conserved stringent response system to prompt transcriptional and metabolic responses toward stress. The adaptive process relies on alarmones,
Publikováno v:
Bioorg Med Chem
6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is a key enzyme in the folate biosynthesis pathway. It catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). HPPK is essential for microorganisms but absent in
Autor:
Mikhail Kashlev, Gary X. Shaw, Ding Jun Jin, Yun-Xing Wang, Smita Kakar, Lucyna Lubkowska, Xinhua Ji, Yan Ning Zhou, Xianyang Fang
Publikováno v:
Journal of Biological Chemistry. 290:23656-23669
Members of the Swi2/Snf2 (switch/sucrose non-fermentable) family depend on their ATPase activity to mobilize nucleic acid-protein complexes for gene expression. In bacteria, RapA is an RNA polymerase (RNAP)-associated Swi2/Snf2 protein that mediates
Double-stranded RNA (dsRNA)-specific ribonuclease III (RNase III) proteins are required for RNA maturation and gene regulation. The mechanism of prokaryotic RNase IIIs has been well characterized, but how eukaryotic RNase IIIs (exemplified by Rnt1p,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab11ba1d9f61c205c2e1ba9c4a27172
https://europepmc.org/articles/PMC5299047/
https://europepmc.org/articles/PMC5299047/
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 75:a106-a106
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 66:554-557
Francisella tularensis, a potential bioweapon, causes a rare infectious disease called tularemia in humans and animals. The macrophage growth locus A (MglA) protein from F. tularensis associates with RNA polymerase to positively regulate the expressi
Autor:
Yan Wu, Xinhua Ji, Honggao Yan, Scott Cherry, Gary X. Shaw, Joseph E. Tropea, David S. Waugh, Yue Li, D. Needle, Genbin Shi, Di Zhang
Publikováno v:
The FEBS journal. 281(18)
UNLABELLED Two valid targets for antibiotic development, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS), catalyze consecutive reactions in folate biosynthesis. In Francisella tularensis (Ft), these two