Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Gary W. McCollum"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Free fatty acid dysregulation in diabetics may elicit the release of inflammatory cytokines from Müller cells (MC), promoting the onset and progression of diabetic retinopathy (DR). Palmitic acid (PA) is elevated in the sera of diabetics an
Externí odkaz:
https://doaj.org/article/47a5c08f9bd747bdbb9357e26fe836ae
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/6e4a97eabf2e40f4839885dd80297f27
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
BackgroundMüller cell (MC) inflammation is an early pathogenic step in the vision-threatening disease diabetic retinopathy (DR). Recent evidence indicates that diabetes-induced free fatty acid (FFA) dysregulation can elicit the release of inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6eeaff8cb5419a6b4d6500e5810bc5
https://doaj.org/article/47a5c08f9bd747bdbb9357e26fe836ae
https://doaj.org/article/47a5c08f9bd747bdbb9357e26fe836ae
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Free fatty acid dysregulation in diabetics may elicit the release of inflammatory cytokines from Müller cells (MC), promoting the onset and progression of diabetic retinopathy (DR). Palmitic acid (PA) is elevated in the sera of diabetics and stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650c2dcd1a2ea961c9fa76eeb3e623d3
http://europepmc.org/articles/PMC8446078
http://europepmc.org/articles/PMC8446078
Human Umbilical Tissue-Derived Cells Secrete Soluble VEGFR1 and Inhibit Choroidal Neovascularization
Autor:
Gary W. McCollum, Rong Yang, John S. Penn, Ian Ross Harris, Steven C. Pomerantz, Theodore Petley, Stephanie M. Evans, Taylor E. Smith, Jing Cao
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Exudative age-related macular degeneration (AMD), characterized by choroidal neovascularization (CNV), is the leading cause of irreversible blindness in developed countries. Anti-vascular endothelial growth factor (VEGF) drugs are the standard treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a3b61ba79590d4e5f1e03321cc17ac
http://europepmc.org/articles/PMC6586593
http://europepmc.org/articles/PMC6586593
Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation
Autor:
Garrett Winkler, Meredith J. Giblin, Minjae J. Kim, Gary W. McCollum, Hannah A. Pendergrass, Taylor E. Smith, Megan E. Capozzi, Rong Yang, John S. Penn
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Chronic low-grade retinal inflammation is an essential contributor to the pathogenesis of diabetic retinopathy (DR). It is characterized by increased retinal cell expression and secretion of a variety of inflammatory cytokines; among these, IL-1β ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e27900e86531c7adb68630bc09ce3bc
https://pubmed.ncbi.nlm.nih.gov/34343639
https://pubmed.ncbi.nlm.nih.gov/34343639
Autor:
Gary W. McCollum, Sara R. Savage, Carla Jhoana Ramos, Sandra S. Hammer, John S. Penn, Rong Yang, Megan E. Capozzi, Colin A. Bretz
Publikováno v:
Exp Eye Res
Diabetic retinopathy (DR) is triggered by retinal cell damage stimulated by the diabetic milieu, including increased levels of intraocular free fatty acids. Free fatty acids may serve as an initiator of inflammatory cytokine release from Muller cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1453827888607118f028529734b99721
https://europepmc.org/articles/PMC7426872/
https://europepmc.org/articles/PMC7426872/
Mouse laser-induced choroidal neovascularization (mouse LCNV) recapitulates the "wet" form of human age-related macular degeneration (AMD). Vascular cell adhesion molecule-1 (VCAM-1) is a known inflammatory biomarker, and it increases in the choroida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876bf6eb0e38962ce4ca02f4204f2bd3
https://europepmc.org/articles/PMC7135968/
https://europepmc.org/articles/PMC7135968/
Autor:
Alexis C. Wong, David W. Wright, John S. Penn, Imam Uddin, Gary W. McCollum, Ashwath Jayagopal
Vascular cell adhesion molecule 1 (VCAM-1) is an important inflammatory biomarker correlating with retinal disease progression. Thus, detection of VCAM-1 mRNA expression levels at an early disease stage could be an important predictive biomarker to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e88f13e411439cc00ce6388ba59ba0
https://europepmc.org/articles/PMC5742066/
https://europepmc.org/articles/PMC5742066/
Publikováno v:
Investigative Ophthalmology & Visual Science. 55:8232-8240
Purpose Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability contributes to diabetic macular edema (DME), a serious vision-threatening condition. Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) antagonist/rever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8772964df13013fe7b9736dd60e0ee43
https://doi.org/10.1167/iovs.14-14217
https://doi.org/10.1167/iovs.14-14217