Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gary W. Gullikson"'
Publikováno v:
FEMS Immunology & Medical Microbiology. 59:81-89
3M-003, like related imidazoquinoline immunomodulators, interacts with Toll-like receptor-7 (TLR-7) and TLR-8. TLRs are important in the defense against fungal pathogens. The effect of 3M-003 on killing of Candida was evaluated on mouse (BALB/c) effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c0466f7606b82162ee89c660a1b52f
https://doi.org/10.1111/j.1574-695x.2010.00664.x
https://doi.org/10.1111/j.1574-695x.2010.00664.x
Autor:
Jody L. Lutterman, Sean M. Mcgurran, Laxma G. Reddy, Kevin S. Gorski, Calin D. Dumitru, Elaine A. Egging, Kenneth E. Lipson, Melissa M. Piri, Gary W. Gullikson, Dave D. Johnson, Felicia R. Cochran, Mark A. Tomai, Mary A. Antonysamy, Joel Proksch
Publikováno v:
Cancer Immunology, Immunotherapy. 58:575-587
Innate immune stimulation with Toll-like receptor (TLR) agonists is a proposed modality for immunotherapy of melanoma. Here, a TLR7/8 agonist, 3M-011, was used effectively as a single systemic agent against disseminated mouse B16-F10 melanoma. The in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdbe93f142191f83b42d1b7b4b788af
https://doi.org/10.1007/s00262-008-0581-7
https://doi.org/10.1007/s00262-008-0581-7
Autor:
David M. Hammerbeck, Sean M. Mcgurran, David D. Johnson, Gary W. Gullikson, Ann M. Hupperts, Pam L. Radziszewski, Elaine A. Egging
Publikováno v:
Inflammation. 24:317-329
Representative glucocorticosteroids (GCS) and phosphodiesterase IV (PDE4) inhibitors were compared in several models of pulmonary inflammation ranging in severity. Lung tissue eosinophil peroxidase (EPO) levels rather than bronchoalveolar lavage flui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f41981ef3c1727d50b49306eafa45327
https://doi.org/10.1023/a:1007092830169
https://doi.org/10.1023/a:1007092830169
Autor:
Daniel L. Flynn, Gary W. Gullikson, Roger Nosal, Dai C. Yang, Daniel Lamar Zabrowski, Daniel P. Becker, Chafiq Moummi, Clara I. Villamil
Publikováno v:
Journal of Medicinal Chemistry. 35:1486-1489
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3639941cbf94a1833d4761d48f2eeaf0
https://doi.org/10.1021/jm00086a019
https://doi.org/10.1021/jm00086a019
Autor:
Steven W. Kramer, R. G. Bianchi, P. W. Collins, Peter H. Jones, E E Yonan, W E Perkins, Gary W. Gullikson, Alan F. Gasiecki, John S. Ng, L Swenton
Publikováno v:
Journal of Medicinal Chemistry. 33:2784-2793
A series of delta 17 unsaturated cycloalkyl and cycloalkenyl analogues of enisoprost was synthesized to investigate the effects of omega chain unsaturation on gastric antisecretory activity and diarrheogenic side effects. Of these, the 17E, 18-cyclop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbad9c3e968e279a7b9a2f08070e682
https://doi.org/10.1021/jm00172a017
https://doi.org/10.1021/jm00172a017
Autor:
Barnett S. Pitzele, Stella S. Yu, R. G. Bianchi, M. Grebner, B. Rubin, Alan E. Moormann, D. Albin, Peter H. Jones, Gary W. Gullikson, E. L. Sanguinetti
Publikováno v:
Journal of Medicinal Chemistry. 33:614-626
Lofexidine, an alpha 2-agonist, has central hypotensive activity and peripheral intestinal antisecretory activity. Analogues were synthesized with increased polarity in an attempt to prevent penetration of the blood-brain barrier. The compounds were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57cc2b09b3d7f609489f5d52a83013a
https://doi.org/10.1021/jm00164a024
https://doi.org/10.1021/jm00164a024
Autor:
Roger Nosal, Alan E. Moormann, Richard F. Loeffler, Daniel L. Flynn, Gary W. Gullikson, Clara I. Villamil, Daniel P. Becker, Chafiq Moummi, Dai-C Yang
Publikováno v:
Journal of medicinal chemistry. 49(3)
A series of pyrrolizidine esters, amides, and ureas was prepared and tested for 5-HT(4) and 5-HT(3) receptor binding, 5-HT(4) receptor agonism in the rat tunica muscularis mucosae (TMM) assay, and for 5-HT(3) receptor-mediated functional antagonism i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96245f0a4c5942c7ba475cf5b51ceebe
https://pubmed.ncbi.nlm.nih.gov/16451077
https://pubmed.ncbi.nlm.nih.gov/16451077
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(22)
Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a-d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT(4) agonist and 5-HT(3) antagonist with in vivo efficacy in gast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1eae133ccc8b139b6e673fc52afb58
https://pubmed.ncbi.nlm.nih.gov/15482914
https://pubmed.ncbi.nlm.nih.gov/15482914
Publikováno v:
Gastroenterology. 73:501-511
The relationship of the surface properties of a group of anionic surfactants to their effects on intestinal water transport was studied. Dose-response inhibition of water transport in everted hamster jejunal segments was obtained with two long chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b9c9b36344d5e14dc7a387640ae9192
https://doi.org/10.1016/s0016-5085(19)32131-6
https://doi.org/10.1016/s0016-5085(19)32131-6
Autor:
D. E. Walters, D. Albin, Gary W. Gullikson, P. Palicharla, R. G. Bianchi, E. L. Sanguinetti, B. S. Pitzele, Alan E. Moormann
Publikováno v:
Journal of Medicinal Chemistry. 31:138-144
Guanabenz, a centrally acting antihypertensive agent, has been shown to have intestinal antisecretory properties. A series of aromatic aminoguanidine hydrazones was made in an effort to separate the antisecretory and cardiovascular activities. Benzal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4663d7b2e92070ba4b9dc5c6e7c9320f
https://doi.org/10.1021/jm00396a020
https://doi.org/10.1021/jm00396a020