Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gary W. Boyle"'
Autor:
Eric L. Nuermberger, Maria Santos Martínez-Martínez, Olalla Sanz, Beatriz Urones, Jorge Esquivias, Heena Soni, Rokeya Tasneen, Sandeep Tyagi, Si-Yang Li, Paul J. Converse, Helena I. Boshoff, Gregory T. Robertson, Gurdyal S. Besra, Katherine A. Abrahams, Anna M. Upton, Khisimuzi Mdluli, Gary W. Boyle, Sam Turner, Nader Fotouhi, Nicholas C. Cammack, Juan Miguel Siles, Marta Alonso, Jaime Escribano, Joel Lelievre, Joaquin Rullas-Trincado, Esther Pérez-Herrán, Robert H. Bates, Gareth Maher-Edwards, David Barros, Lluís Ballell, Elena Jiménez
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
As a result of a high-throughput compound screening campaign using Mycobacterium tuberculosis -infected macrophages, a new drug candidate for the treatment of tuberculosis has been identified. GSK2556286 inhibits growth within human macrophages (50%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a0efb69d85ba133e740da0ce522724b
https://doi.org/10.1128/aac.00132-22
https://doi.org/10.1128/aac.00132-22
Autor:
Eric L, Nuermberger, Maria Santos, Martínez-Martínez, Olalla, Sanz, Beatriz, Urones, Jorge, Esquivias, Heena, Soni, Rokeya, Tasneen, Sandeep, Tyagi, Si-Yang, Li, Paul J, Converse, Helena I, Boshoff, Gregory T, Robertson, Gurdyal S, Besra, Katherine A, Abrahams, Anna M, Upton, Khisimuzi, Mdluli, Gary W, Boyle, Sam, Turner, Nader, Fotouhi, Nicholas C, Cammack, Juan Miguel, Siles, Marta, Alonso, Jaime, Escribano, Joel, Lelievre, Joaquin, Rullas-Trincado, Esther, Pérez-Herrán, Robert H, Bates, Gareth, Maher-Edwards, David, Barros, Lluís, Ballell, Elena, Jiménez
Publikováno v:
Antimicrob Agents Chemother
As a result of a high-throughput compound screening campaign using Mycobacterium tuberculosis-infected macrophages, a new drug candidate for the treatment of tuberculosis has been identified. GSK2556286 inhibits growth within human macrophages (50% i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e70e501c1e66105a3a8f4f58af08ae3
https://pubmed.ncbi.nlm.nih.gov/35607978
https://pubmed.ncbi.nlm.nih.gov/35607978
Autor:
Marion Flipo, Rosangela Frita, Marilyne Bourotte, María S. Martínez-Martínez, Markus Boesche, Gary W. Boyle, Geo Derimanov, Gerard Drewes, Pablo Gamallo, Sonja Ghidelli-Disse, Stephanie Gresham, Elena Jiménez, Jaime de Mercado, Esther Pérez-Herrán, Esther Porras-De Francisco, Joaquín Rullas, Patricia Casado, Florence Leroux, Catherine Piveteau, Mehdi Kiass, Vanessa Mathys, Karine Soetaert, Véronique Megalizzi, Abdalkarim Tanina, René Wintjens, Rudy Antoine, Priscille Brodin, Vincent Delorme, Martin Moune, Kamel Djaout, Stéphanie Slupek, Christian Kemmer, Marc Gitzinger, Lluis Ballell, Alfonso Mendoza-Losana, Sergio Lociuro, Benoit Deprez, David Barros-Aguirre, Modesto J. Remuiñán, Nicolas Willand, Alain R. Baulard
Publikováno v:
Science Translational Medicine. 14
The sensitivity of Mycobacterium tuberculosis , the pathogen that causes tuberculosis (TB), to antibiotic prodrugs is dependent on the efficacy of the activation process that transforms the prodrugs into their active antibacterial moieties. Various o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceee95809e2bca056e0d0c0c3d88cddd
https://doi.org/10.1126/scitranslmed.aaz6280
https://doi.org/10.1126/scitranslmed.aaz6280
Autor:
Marion, Flipo, Rosangela, Frita, Marilyne, Bourotte, María S, Martínez-Martínez, Markus, Boesche, Gary W, Boyle, Geo, Derimanov, Gerard, Drewes, Pablo, Gamallo, Sonja, Ghidelli-Disse, Stephanie, Gresham, Elena, Jiménez, Jaime, de Mercado, Esther, Pérez-Herrán, Esther, Porras-De Francisco, Joaquín, Rullas, Patricia, Casado, Florence, Leroux, Catherine, Piveteau, Mehdi, Kiass, Vanessa, Mathys, Karine, Soetaert, Véronique, Megalizzi, Abdalkarim, Tanina, René, Wintjens, Rudy, Antoine, Priscille, Brodin, Vincent, Delorme, Martin, Moune, Kamel, Djaout, Stéphanie, Slupek, Christian, Kemmer, Marc, Gitzinger, Lluis, Ballell, Alfonso, Mendoza-Losana, Sergio, Lociuro, Benoit, Deprez, David, Barros-Aguirre, Modesto J, Remuiñán, Nicolas, Willand, Alain R, Baulard
Publikováno v:
Science translational medicine. 14(643)
The sensitivity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::316d4fab7d2470a0398fb8eaba9aa28a
https://pubmed.ncbi.nlm.nih.gov/35507672
https://pubmed.ncbi.nlm.nih.gov/35507672
Autor:
Eric L. Nuermberger, Maria Santos Martínez-Martínez, Olalla Sanz, Beatriz Urones, Jorge Esquivias, Heena Soni, Rokeya Tasneen, Sandeep Tyagi, Si-Yang Li, Paul J. Converse, Helena I. Boshoff, Gregory T Robertson, Gurdyal S Besra, Katherine A. Abrahams, Anna M Upton, Khisimuzi Mdluli, Gary W Boyle, Sam Turner, Nader Fotouhi, Nicholas C. Cammack, Juan Miguel Siles, Marta Alonso, Jaime Escribano, Joel Lelievre, Esther Pérez-Herrán, Robert H. Bates, Gareth Maher-Ewards, David Barros, Lluís Ballell, Elena Jiménez
As a result of a high-throughput compound screening campaign of Mycobacterium tuberculosis infected macrophages, a new preclinical drug candidate for the treatment of tuberculosis has been identified. GSK2556286 inhibits growth within human macrophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a984612053fc1c94c88fa6be2f2d6122
https://doi.org/10.1101/2022.02.04.479214
https://doi.org/10.1101/2022.02.04.479214
Autor:
Mark Wright, Stefano Zamuner, Paolo Bettica, Mario Pellegatti, Steven R. Thomas, Gary W. Boyle, Cecilia Renzulli, Mike Nash
Publikováno v:
Drug Metabolism and Disposition. 39:215-227
N -[[(2 S )-1-[[5-(4-fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide (SB-649868) is a novel orexin 1 and 2 receptor antagonist under development for insomnia treatment. The disposition of [ 14 C]SB-649868 wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893492fb878b28111917fefe6e2dd81d
https://doi.org/10.1124/dmd.110.035386
https://doi.org/10.1124/dmd.110.035386
Autor:
Graeme Young, Mehul Dave, Mike Nash, Harma Ellens, Andrew D. Roberts, Robert W. Greenhill, Maxine A. Taylor, Mindy Magee, Gary W. Boyle
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(3)
The absorption, metabolism, and excretion of darapladib, a novel inhibitor of lipoprotein-associated phospholipase A2, was investigated in healthy male subjects using [(14)C]-radiolabeled material in a bespoke study design. Disposition of darapladib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446d8db1d7a5cf4a00a8860b6fba8bc1
https://pubmed.ncbi.nlm.nih.gov/24378325
https://pubmed.ncbi.nlm.nih.gov/24378325