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pro vyhledávání: '"Gary W Hesse"'
Publikováno v:
Journal of neuroscience methods. 379
Publikováno v:
Journal of Neuroscience Methods. 185:62-65
Neuroscience research projects often use intracranial (IC) microinfusions to target drug delivery to specific brain areas during behavioral testing. These experiments require accurate and precisely-timed delivery of small volumes. We present here a s
Publikováno v:
Journal of Neuroscience Methods. 72:35-38
A stepper motor-powered micropump for making intracerebral microinjections in freely moving animals is described. The micropump is capable of delivering fluid volumes of up to 20 microl in steps of 17 nl The system does not require a fluid swivel, de
Autor:
Victor E. Shashoua, Gary W. Hesse
Publikováno v:
Life Sciences. 58:1347-1357
Fatty acids with varying chain lengths ( 2–22 carbon atoms long ) and degrees of unsaturation (0–6 double bonds) were used to synthesize dopaminergic compounds for a study of the carrier mediated transport of dopamine (DA) to the brain. The most
Publikováno v:
Journal of neuroscience methods. 185(1)
Neuroscience research projects often use intracranial (IC) microinfusions to target drug delivery to specific brain areas during behavioral testing. These experiments require accurate and precisely-timed delivery of small volumes. We present here a s
Publikováno v:
Journal of Medicinal Chemistry. 33:733-736
1-O-Linolenoyl-2-O-(4-aminobutyryl)-3-O-(4-vinyl-4-aminobutyryl)glycerol (LGV) was synthesized as an example of a prodrug which readily penetrates the blood-brain barrier (brain penetration index 97% +/- 15%) and releases two active substances in the
Publikováno v:
Pharmacology, biochemistry, and behavior. 71(3)
Intracranial self-administration of drugs offers the opportunity to localize the neuronal substrates mediating the rewarding effects of drugs. The purpose of the present study was to explore whether the nucleus accumbens shell and the central nucleus
Publikováno v:
Brain research. 522(2)
Ependymin, a glycoprotein of the brain extracellular fluid, has been implicated in synaptic changes associated with the consolidation process of long-term memory formation and the activity-dependent sharpening of connections of regenerating optic ner
Autor:
Gary W. Hesse, Victor E. Shashoua
Publikováno v:
Neuroscience letters. 109(1-2)
Physiologically viable slices of rat hippocampus were incubated in radiolabeled valine, then cut into 20 μm serial sections to evaluate the profile of protein synthesis through the depth of the slice. Maximum radiolabel incorporation was observed ne
Publikováno v:
Neuropharmacology. 27:637-640
Two lipid esters of γ-aminobutyric acid (GABA), 1-linolenoyl-2,3-bis(4-aminobutyryl) propane-1,2,3-triol and 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol, were found to have brain uptake indices of greater than 30% using the single-pass ca