Výsledky vyhledávání - "Gary Van Nest"

Akademický článek

Local Induction of a Specific Th1 Immune Response by Allergen Linked Immunostimulatory DNA in the Nasal Explants of Ragweed- Allergic Subjects

Autor: Meri K Tulic, Pota Christodoulopoulos, Pierre Olivier Fiset, Patrice Vaillancourt, Francois Lavigne, Jason D Marshall, Gary Van Nest, Joseph J Eiden, Qutayba Hamid

Publikováno v: Allergology International, Vol 58, Iss 4, Pp 565-572 (2009)

Background: Allergen immunotherapy is effective in allergic individuals however efforts are being made to improve its safety, convenience, and efficacy. It has recently been demonstrated that allergen-linked immunostimulatory DNA (ISS) is effective i

Externí odkaz: https://doaj.org/article/3a22af19e0414b69a01dd460b4e374d6

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Cytomegalovirus Vaccine Strain Towne-Derived Dense Bodies Induce Broad Cellular Immune Responses and Neutralizing Antibodies That Prevent Infection of Fibroblasts and Epithelial Cells

Autor: Alivelu Irrinki, Nga Nguyen, Corinne Cayatte, A. Louise McCormick, Hong Jin, Christine Nelson, Lorraine Gemmell, Esteban Servat, Andrzej Citkowicz, Jennifer Woo, Gregory Duke, Janine Lu, Yi Liu, Zhaoti Wang, Gregory M. Hayes, Kirsten Schneider-Ohrum, Gary Van Nest

Publikováno v: Journal of Virology. 87:11107-11120

Human cytomegalovirus (HCMV), a betaherpesvirus, can cause severe disease in immunosuppressed patients and following congenital infection. A vaccine that induces both humoral and cellular immunity may be required to prevent congenital infection. Dens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edc891d4850b8310ae2d95317aa836f
https://doi.org/10.1128/jvi.01554-13

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Immunostimulatory DNA as a vaccine adjuvant

Autor: Jason Marshall, Gary Van Nest, Brian D. Livingston, Debbie Higgins, Paula Traquina

Publikováno v: Expert Review of Vaccines. 6:747-759

Immunostimulatory DNA containing unmethylated CpG motifs is recognized by Toll-like receptor 9, resulting in the activation of innate immune responses that subsequently amplify the adaptive-immune response. Advances in the characterization of Toll-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3249425e05c3f12163d46178c46d29
https://doi.org/10.1586/14760584.6.5.747

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Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults

Autor: Robyn McCall-Sani, Shelly A. McNeil, Simon Dobson, Dan Levitt, Bruce Smith, Gary Van Nest, Joanne M. Langley, Daniel Gennevois, Joseph Eiden, Scott A. Halperin

Publikováno v: Vaccine. 24:20-26

Background Many individuals do not respond to a three-dose series of hepatitis B vaccine (HBV) and most do not achieve a protective antibody response until after dose 2 or 3. Methods Healthy, seronegative 18–28 year old adults were randomly assigne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77efa15b49939eef89399b12b7e294e9
https://doi.org/10.1016/j.vaccine.2005.08.095

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Induction of interferon-gamma from natural killer cells by immunostimulatory CpG DNA is mediated through plasmacytoid-dendritic-cell-produced interferon-alpha and tumour necrosis factor-alpha

Autor: Jason Marshall, Darren S. Heeke, Gary Van Nest, Christi Abbate, Priscilla Yee

Publikováno v: Immunology. 117:38-46

Immunostimulatory sequences (ISS) that contain CpG motifs have been demonstrated to exert antipathogen and antitumour immunity in animal models through several mechanisms, including the activation of natural killer (NK) cells to secrete interferon-ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc499ec3da1bd692af68b572639d8e1
https://doi.org/10.1111/j.1365-2567.2005.02261.x

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CpG-C Immunostimulatory Oligodeoxyribonucleotide Activation of Plasmacytoid Dendritic Cells in Rhesus Macaques to Augment the Activation of IFN-γ-Secreting Simian Immunodeficiency Virus-Specific T Cells

Autor: Jeffrey D. Lifson, Rudolf P. Bohm, Jason Marshall, Jessica Kenney, Gary Van Nest, Jason Dufour, Melissa Pope, Agegnehu Gettie, Jennifer Jones, Natalia Teleshova

Publikováno v: The Journal of Immunology. 173:1647-1657

There are two principle subsets of dendritic cells (DCs); CD11c+CD123− myeloid DCs (MDCs) and CD11c−CD123+ plasmacytoid DCs (PDCs). DC activation via TNF-TNFRs (e.g., CD40L) and TLRs (e.g., immunostimulatory oligodeoxyribonucleotides (ISS-ODNs))

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7b98b6da460864a16132e0466224fe
https://doi.org/10.4049/jimmunol.173.3.1647

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Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA

Autor: Joseph Eiden, Kent T. HayGlass, Gary Van Nest, Yasufumi Shikishima, F. Estelle R. Simons

Publikováno v: Journal of Allergy and Clinical Immunology. 113:1144-1151

Background In animal models administration of immunostimulatory DNA sequences preferentially elicits T H 1-dominated (type 1-dominated) immunity and can inhibit developing or ongoing T H 2 (type 2) responses. Objective Our objective was to investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babf37aafa528f29b6b1cc16be82caaa
https://doi.org/10.1016/j.jaci.2004.03.003

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Polymyxin B enhances ISS-mediated immune responses across multiple species

Autor: Christi Abbate, Karen L. Fearon, Tracy dela Cruz, Debbie Higgins, Gary Van Nest, David Passmore, Jason Marshall, Stephen Tuck, Gary Ott, Priscilla Yee, Glen Teshima

Publikováno v: Cellular Immunology. 229:93-105

The immunostimulatory effects of bacterial DNA on mammalian cells have been localized to unmethylated CpG motifs, and synthetic CpG-containing oligodeoxynucleotides that mimic these effects are known as immunostimulatory sequences (ISS). We have foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157d5f2381cd844b670c6aa8ebdfc3b6
https://doi.org/10.1016/j.cellimm.2004.04.009

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Palivizumab epitope-displaying virus-like particles protect rodents from RSV challenge

Autor: Gary Van Nest, Darrell L. Peterson, David R. Milich, Roderick Tang, Joyce E. Jones, Michael P. McCarthy, Heather Lawlor, Jasmine Kaur, David C. Whitacre, Jeanne H. Schickli, Cory J. Peters

Publikováno v: The Journal of clinical investigation. 125(4)

Respiratory syncytial virus (RSV) is the most common cause of serious viral bronchiolitis in infants, young children, and the elderly. Currently, there is not an FDA-approved vaccine available for RSV, though the mAb palivizumab is licensed to reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80efce39d4bb5b6814f9c3b4d1f1760
https://pubmed.ncbi.nlm.nih.gov/25751145

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Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity

Autor: David A. Schwartz, Joseph Eiden, Stephen Tuck, Anne Kagey-Sobotka, Gary Van Nest, Peter S. Creticos, Kenji Takabayashi, H Tighe, Lawrence M. Lichtenstein, Hans L. Spiegelberg, Eyal Raz

Publikováno v: Journal of Allergy and Clinical Immunology. 106:124-134

Background: Allergen immunotherapy is inconvenient and associated with the risk of anaphylaxis. Efforts to improve the safety of immunotherapy by means of chemical modification of allergens have not been successful because it greatly reduced their an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3991094b1b6b91004bcb2d837c824140
https://doi.org/10.1067/mai.2000.107927

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