Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Gary Tin"'
Autor:
Chrysanthi Kagiou, Jose A. Cisneros, Jakob Farnung, Joanna Liwocha, Fabian Offensperger, Kevin Dong, Ka Yang, Gary Tin, Christina S. Horstmann, Matthias Hinterndorfer, Joao A. Paulo, Natalie S. Scholes, Juan Sanchez Avila, Michaela Fellner, Florian Andersch, J. Thomas Hannich, Johannes Zuber, Stefan Kubicek, Steven P. Gygi, Brenda A. Schulman, Georg E. Winter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the proteasome. Only a few of the approximately 600 human E3 ligases are currently amenable to t
Externí odkaz:
https://doaj.org/article/122c230e01c4426bb2025a22bb1c70c0
Autor:
Helena Sorger, Saptaswa Dey, Pablo Augusto Vieyra‐Garcia, Daniel Pölöske, Andrea R Teufelberger, Elvin D deAraujo, Abootaleb Sedighi, Ricarda Graf, Benjamin Spiegl, Isaac Lazzeri, Till Braun, Ines Garces de los Fayos Alonso, Michaela Schlederer, Gerald Timelthaler, Petra Kodajova, Christine Pirker, Marta Surbek, Michael Machtinger, Thomas Graier, Isabella Perchthaler, Yi Pan, Regina Fink‐Puches, Lorenzo Cerroni, Jennifer Ober, Moritz Otte, Jana D Albrecht, Gary Tin, Ayah Abdeldayem, Pimyupa Manaswiyoungkul, Olasunkanmi O Olaoye, Martin L Metzelder, Anna Orlova, Walter Berger, Marion Wobser, Jan P Nicolay, Fiona André, Van Anh Nguyen, Heidi A Neubauer, Roman Fleck, Olaf Merkel, Marco Herling, Ellen Heitzer, Patrick T Gunning, Lukas Kenner, Richard Moriggl, Peter Wolf
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 12, Pp n/a-n/a (2022)
Abstract Leukemic cutaneous T‐cell lymphomas (L‐CTCL) are lymphoproliferative disorders of skin‐homing mature T‐cells causing severe symptoms and high mortality through chronic inflammation, tissue destruction, and serious infections. Despite
Externí odkaz:
https://doaj.org/article/c1ee8bac3c164d9b80fc189cf3bc69bf
Autor:
Emir Hadzijusufovic, Alexandra Keller, Daniela Berger, Georg Greiner, Bettina Wingelhofer, Nadine Witzeneder, Daniel Ivanov, Emmanuel Pecnard, Harini Nivarthi, Florian K. M. Schur, Yüksel Filik, Christoph Kornauth, Heidi A. Neubauer, Leonhard Müllauer, Gary Tin, Jisung Park, Elvin D. de Araujo, Patrick T. Gunning, Gregor Hoermann, Fabrice Gouilleux, Robert Kralovics, Richard Moriggl, Peter Valent
Publikováno v:
Cancers, Vol 12, Iss 4, p 1021 (2020)
Janus kinase 2 (JAK2) and signal transducer and activator of transcription-5 (STAT5) play a key role in the pathogenesis of myeloproliferative neoplasms (MPN). In most patients, JAK2 V617F or CALR mutations are found and lead to activation of various
Externí odkaz:
https://doaj.org/article/494aea63783c415ab27e28b73df36d58
Autor:
Ho, Jane Pui-Ying, Lau, Eric Siu-Him, Kwan O, Chun, Fan, Baoqi, Ko, Gary Tin-Choi, Kong, Alice Pik-Shan, Ma, Ronald Ching-Wan, Chow, Elaine Yee-Kwan, Chan, Juliana Chung-Ngor, Luk, Andrea On-Yan
Publikováno v:
In Diabetes Research and Clinical Practice June 2024 212
Autor:
Gary, Tin, Georg E, Winter
Publikováno v:
Nature chemical biology. 19(1)
Autor:
Au, Doreen W.H., Tsang, Hector W.H., So, Wendy W.Y., Bell, Morris D., Cheung, Vinci, Yiu, Michael G.C., Tam, K.L., Lee, Gary Tin-ho
Publikováno v:
In Schizophrenia Research August 2015 166(1-3):297-303
Autor:
Tam, Wing Hung, Ma, Ronald Ching Wan, Yip, Gabriel Wai kwok, Yang, Xilin, Li, Albert Martin, Ko, Gary Tin Choi, Lao, Terence Tzu-Hsi, Chan, Juliana Chung Ngor
Publikováno v:
In Diabetes Research and Clinical Practice 2012 95(1):169-175
Autor:
Cheung, Lorena Tsui Fun1 lorena.cheung@link.cuhk.edu.hk, Ko, Gary Tin Choi1, Chow, Francis Chun Chung1, Kong, Alice Pik Shan1
Publikováno v:
Journal of Diabetes Investigation. Sep2018, Vol. 9 Issue 5, p1135-1143. 9p.
Autor:
Diana Sina, Pimyupa Manaswiyoungkul, Karen Yuen, Patrick T. Gunning, Fettah Erdogan, Elvin D. de Araujo, Gary Tin, Abdul K. Qadree, Krimo Toutah
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 162:60-65
Inhibition of STAT phosphorylation is recognized as a viable therapeutic strategy for disrupting tumorigenesis. Constitutive STAT phosphorylation is found with high frequency in a number of primary tumor types, while non-cancer cells exhibit low basa
Publikováno v:
Alzheimer's & Dementia. 16