Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Gary T. Elliott"'
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 117-126 (2022)
Mitochondria are key tumor drivers, but their suitability as a therapeutic target is unknown. Here, we report on the preclinical characterization of Gamitrinib (GA mitochondrial matrix inhibitor), a first-in-class anticancer agent that couples the He
Externí odkaz:
https://doaj.org/article/323440b459744844bcf3002c13b30f4e
Autor:
Que Liu, Peter R. Kowey, Tengxian Liu, Donglin Guo, Mireille Gingras, Gan-Xin Yan, Gary T. Elliott
Publikováno v:
Journal of Cardiovascular Pharmacology. 57:79-85
HBI-3000 (sulcardine sulfate) has been shown to suppress various ventricular arrhythmias in animal models. The electrophysiological properties of HBI-3000 were investigated using standard microelectrode and patch-clamp techniques in single human vent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347ff85bd65268dd8af1696d5bd066b7
https://doi.org/10.1097/fjc.0b013e3181ffe8b3
https://doi.org/10.1097/fjc.0b013e3181ffe8b3
Autor:
Noopur Raje, Enrique M. Ocio, Simona Blotta, Teru Hideshima, Catley P. Laurence, Hiroshi Yasui, Paola Neri, Gary T. Elliott, Kenneth C. Anderson, Sarath Kanekal, Tanyel Kiziltepe, Pierfrancesco Tassone, Kenji Ishitsuka, Nikhil C. Munshi, Mariateresa Fulciniti
Publikováno v:
British Journal of Haematology. 134:37-44
SummaryGlucocorticoids have been widely used in the treatment of multiple myeloma(MM) both as single agents and in combination with other drugs. However,primary or acquired glucocorticoid resistance occurs in most cases. It wasrecently reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40f0a71372af96c1cff5e1db2a9cd66
https://doi.org/10.1111/j.1365-2141.2006.06122.x
https://doi.org/10.1111/j.1365-2141.2006.06122.x
Autor:
Gary T. Elliott, Kenji Ishitsuka, Shaji Kumar, Klaus Podar, Noopur Raje, Nikhil C. Munshi, Lorenzo M. Leoni, Aldo M. Roccaro, Pierfrancesco Tassone, Teru Hideshima, Kenneth C. Anderson, Norihiko Shiraishi, Makoto Hamasaki, Sarath Kanekal, Dharminder Chauhan, Yu-Tzu Tai, Hiroshi Yasui
Publikováno v:
Blood. 106:706-712
In this study we report that R-etodolac (SDX-101), at clinically relevant concentrations, induces potent cytotoxicity in drug-sensitive multiple myeloma (MM) cell lines, as well as in dexamethasone (MM.1R)-, doxorubicin (Dox40/RPMI8226)-, and bortezo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4913be34c357c70d319730b76abad126
https://doi.org/10.1182/blood-2005-02-0838
https://doi.org/10.1182/blood-2005-02-0838
Publikováno v:
Journal of Cardiovascular Pharmacology. 32:337-342
Summary: We sought to determine the role of opening of adenosine triphosphate (ATP)-sensitive potassium channel (KATP channel) in monophosphoryl lipid A (MLA)-induced myocardial protection after ischemia/reperfusion (I/R) in rabbit. We used 5-hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a5983c65495013f4de420e3ca77918
https://doi.org/10.1097/00005344-199809000-00001
https://doi.org/10.1097/00005344-199809000-00001
Autor:
Gary T. Elliott
Publikováno v:
Journal of Molecular and Cellular Cardiology. 30:3-17
Monophosphoryl lipid A represents a novel agent capable of enhancing myocardial tolerance to ischemia/reperfusion injury. This cardioprotective activity of MLA manifests itself as a reduction in infarct size, myocardial stunning and dysrhythmias in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3283cb310df85cc208a9666f968ab46
https://doi.org/10.1006/jmcc.1997.0586
https://doi.org/10.1006/jmcc.1997.0586
Autor:
Mohammed A. Nayeem, Gary T. Elliott, Rakesh C. Kukreja, Maulik Shah, Samantha L Hastillo-Hess
Publikováno v:
Journal of Molecular and Cellular Cardiology. 29:2305-2310
We examined the in vitro preconditioning effect of non-toxic derivative of endotoxin, monophosphoryl lipid A (MLA) in adult rat cardiac myocytes. Cultured 5-7-day-old myocytes were preconditioned for 4 h by treatment with 200 ng/ml MLA. Twenty h late
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fbace30ffe9f40fd0bea292a97c48e
https://doi.org/10.1006/jmcc.1997.0452
https://doi.org/10.1006/jmcc.1997.0452
Autor:
Gary T. Elliott
Publikováno v:
Annals of the New York Academy of Sciences. 793:386-399
As the mechanism of ischemic preconditioning unfolds, various strategies for inducing pharmacologic preconditioning become apparent. Adenosine receptor agonists, KATP channel activators, and endothelial-neutrophil adhesion antagonists have enjoyed ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f490f3a3aee5f53240ce429cd5a1ad
https://doi.org/10.1111/j.1749-6632.1996.tb33530.x
https://doi.org/10.1111/j.1749-6632.1996.tb33530.x
Publikováno v:
Pharmacology. 51:152-159
The effects of a 1- or 24-hour pretreatment regimen with monophosphoryl lipid A (MLA, 35 micrograms/kg i.v.) on myocardial stunning produced by repetitive coronary occlusions were studied in barbital-anesthetized dogs. Regional segment function (%SS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06263c3d8a117611f157ee3f25b530d
https://doi.org/10.1159/000139329
https://doi.org/10.1159/000139329
Publikováno v:
Journal of Immunotherapy. 10:69-74
Mice are relatively resistant to the lethal effects of endotoxin. Sensitivity to lipopolysaccharide (LPS) and monophosphoryl lipid A (MPL) can be enhanced by concurrently loading animals with D-galactosamine (D-gal). Significant diurnal variation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721a70cd0fea45ed04ad3f4b904b8c0a
https://doi.org/10.1097/00002371-199102000-00010
https://doi.org/10.1097/00002371-199102000-00010