Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Gary Stuart Tilbrook"'
1
CNS 7056
Autor: Gary Stuart Tilbrook, Gavin J. Kilpatrick, Barbara L. Waszczak, Margaret S McIntyre, Richard F. Cox, Holly A. Collins, Gwyer G Lovell, Gregory J Pacofsky, Robert P. Wiard, Jeffrey A. Stafford, Paul L. Feldman
Publikováno v: Anesthesiology. 107:60-66
Background: A new benzodiazepine derivative, CNS 7056, has been developed to permit a superior sedative profile to current agents, i.e., more predictable fast onset, short duration of sedative action, and rapid recovery profile. This goal has been ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14c2bac3526d1c834ff29602b6309efa
https://doi.org/10.1097/01.anes.0000267503.85085.c0
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2
A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part II. Population pharmacokinetic and pharmacodynamic modeling and simulation
Autor: Keith M. Borkett, Gavin J. Kilpatrick, Gary Stuart Tilbrook, Hugh Wiltshire
Publikováno v: Anesthesia and analgesia. 115(2)
A new benzodiazepine, remimazolam, which is rapidly metabolized by tissue esterases to an inactive metabolite, has been developed to permit a fast onset, a short, predictable duration of sedative action, and a more rapid recovery profile than current
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00459b7f721476c262e30c8eb4e3f8bc
https://pubmed.ncbi.nlm.nih.gov/23788743
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3
A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part I. Safety, efficacy, and basic pharmacokinetics
Autor: Keith M. Borkett, Gavin J. Kilpatrick, Laurie J. Antonik, Gary Stuart Tilbrook, D. Ronald Goldwater
Publikováno v: Anesthesia and analgesia. 115(2)
A new benzodiazepine, remimazolam, metabolized by tissue esterases to an inactive compound, CNS 7054, has been developed to permit a fast onset, a short and more predictable duration of sedative action, and a more rapid recovery profile than with cur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cab25e34db31f303d5c46ca4f1c259
https://pubmed.ncbi.nlm.nih.gov/22826519
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4
Drug development in anaesthesia: industrial perspective
Autor: Gary Stuart Tilbrook, Gavin J. Kilpatrick
Publikováno v: Current opinion in anaesthesiology. 19(4)
Purpose of review In this review, we summarize the new drugs in development in the anaesthesia field. Recent findings There are some interesting approaches, including pro-drugs of propofol such as Aquavan (MGI Pharma, Bloomington, Minnesota, USA) and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695965e94cda14621f81ca48fbf74c4f
https://pubmed.ncbi.nlm.nih.gov/16829719
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5
Synthesis and physicochemical assessment of novel 2-substituted 3-hydroxypyridin-4-ones, novel iron chelators
Autor: Hicham Khodr, Gary Stuart Tilbrook, Majid Yousefi Moridani, Robert C. Hider
Publikováno v: The Journal of pharmacy and pharmacology. 54(3)
Novel 3-hydroxypyridin-4-one containing tridentate ligands were synthesised and their physicochemical properties characterised, including ionisation constants and stoichiometric titration with Fe(III). There is an urgent demand for orally active iron
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84ebc5db6f10383ecf942b53b972ac6
https://pubmed.ncbi.nlm.nih.gov/11902801
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