Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Gary Sieck"'
Publikováno v:
Physiological Reports, Vol 10, Iss 14, Pp n/a-n/a (2022)
Abstract Nitric oxide (NO) is thought to increase cardiac contractility by increasing cytosolic Ca2+ concentration ([Ca2+]cyt) during excitation. Alternatively, NO could increase the sensitivity of the contractile response to [Ca2+]cyt (Ca2+ sensitiv
Externí odkaz:
https://doaj.org/article/fab1467436c74a88a279e34c6ca52349
Autor:
Brent Berry, Yogatheesan Varatharajah, Vaclav Kremen, Michal Kucewicz, Hari Guragain, Benjamin Brinkmann, Juliano Duque, Diego Z. Carvalho, Matt Stead, Gary Sieck, Gregory Worrell
Publikováno v:
Life, Vol 13, Iss 5, p 1186 (2023)
Low frequency brain rhythms facilitate communication across large spatial regions in the brain and high frequency rhythms are thought to signify local processing among nearby assemblies. A heavily investigated mode by which these low frequency and hi
Externí odkaz:
https://doaj.org/article/ff374f4cacb54c2491acef35919ce862
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
Chronic mountain sickness (CMS) is a disease that potentially threatens a large segment of high-altitude populations during extended living at altitudes above 2,500 m. Patients with CMS suffer from severe hypoxemia, excessive erythrocytosis and neuro
Externí odkaz:
https://doaj.org/article/8eeb720562a44db193b369a14aeb2a96
Autor:
Janina Benade, Lucien Sher, Sheneez De Klerk, Gaurang Deshpande, Dirk Bester, Jeanine L. Marnewick, Gary Sieck, Ismail Laher, M. Faadiel Essop
Publikováno v:
Antioxidants, Vol 9, Iss 7, p 569 (2020)
Cardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this study aimed to obtain greate
Externí odkaz:
https://doaj.org/article/eae5ff40b304415f9606c7a6357029b7
Publikováno v:
Physiology. 38
Succinate dehydrogenase (SDH) is a key enzyme in the tricarboxylic acid (TCA) cycle, as well as Complex II of the electron transport chain (ETC). In the SDH reaction, succinate is oxidized to fumarate in the TCA cycle, producing FADH2 contributing to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8669a655a8d0278ffe20a20d196a4ef
https://doi.org/10.1152/physiol.2023.38.s1.5733899
https://doi.org/10.1152/physiol.2023.38.s1.5733899
Autor:
Sanjana Mahadev Bhat, Gary Sieck
Publikováno v:
Physiology. 38
Succinate dehydrogenase (SDH) is a mitochondrial enzyme that participates in both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) as Complex II. In the TCA cycle, SDH catalyzes the oxidation of succinate to fumarate, which i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ee3c74c011c5e0de4fab20a8823cd96
https://doi.org/10.1152/physiol.2023.38.s1.5727552
https://doi.org/10.1152/physiol.2023.38.s1.5727552
Publikováno v:
Physiology. 38
Airway inflammation is the central driver behind the pathogenesis of respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, and the very recent pandemic outbreak of COVID-19. Previous studies reported t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4717c532e3c77cb64d704c0783de323c
https://doi.org/10.1152/physiol.2023.38.s1.5732514
https://doi.org/10.1152/physiol.2023.38.s1.5732514
Publikováno v:
Physiology. 38
During embryonic development, the number of phrenic motor neurons (PhMNs) declines precipitously during the final trimester and continues into the early postnatal period. When BDNF/TrkB signaling is absent in utero, animals do not survive after birth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::848bfa35df20e8810dc4b33a515fdc8e
https://doi.org/10.1152/physiol.2023.38.s1.5729624
https://doi.org/10.1152/physiol.2023.38.s1.5729624
Publikováno v:
Physiology. 38
Mitophagy is a regulated multistep process of selective removal of dysfunctional/damaged mitochondria by autophagy and is critical for the regulation of mitochondrial quality control in many physiological processes. The best characterized pathway of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14bb56ef41b922703794e1a5ef380f6e
https://doi.org/10.1152/physiol.2023.38.s1.5727564
https://doi.org/10.1152/physiol.2023.38.s1.5727564
Publikováno v:
Physiology. 38
Autophagy is a process through which damaged cytoplasmic structures are recycled and degraded within the cell. Aging can affect autophagy regulation in different steps and lead to the accumulation of altered proteins, leading to cell damage and death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4abac45e95a24367c10d7f7378fd61c
https://doi.org/10.1152/physiol.2023.38.s1.5729928
https://doi.org/10.1152/physiol.2023.38.s1.5729928