Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gary Salmon"'
Autor:
Dan Sexton, Ryan Faucette, Melody Rivera-Hernandez, Jon A. Kenniston, Nikolaos Papaioannou, Janja Cosic, Kris Kopacz, Gary Salmon, Chantal Beauchemin, Salomé Juethner, Dave Yeung
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
BackgroundCleaved high-molecular-weight kininogen (HKa) is a disease state biomarker of kallikrein-kinin system (KKS) activation in patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH), the endogenous inhibitor of plasma kal
Externí odkaz:
https://doaj.org/article/0d761743922e42949564199f1786651f
Autor:
Xingrong Liu, Nico Ghilardi, Simon Charles Goodacre, Michael Siu, Jim Nonomiya, G. Buckley, Adam R. Johnson, Yun-Xing Cheng, F.A. Romero, Nick Ray, Rohan Mendonca, C. Robinson, Yuen Po-Wai, Jane R. Kenny, Marya Liimatta, Terry Kellar, Mark Zak, Gary Salmon, J. Lloyd, D.G. Brown, Neville James Mclean, Joseph P. Lyssikatos, Emily J. Hanan, Patrick J. Lupardus, Pawan Bir Kohli, Christopher A. Hurley, Guiling Zhao, Paul Gibbons, Peter H. Crackett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1522-1531
Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor
Autor:
Gary Salmon, Harvey Wong, Maxine Norman, Adrian Barnard, Aihe Zhou, Julie Hawkins, Benjamin Fauber, Adam R. Johnson, Arunima Ganguli, Yuzhong Deng, Susan Summerhill, Kirk Robarge, Celine Eidenschenk, Wenjun Ouyang, Christine Everett, Jianhua Cao, Wei Tang, Hank La, Alberto Gobbi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2907-2912
The nuclear receptor (NR) retinoic acid receptor-related orphan receptor gamma (RORγ, RORc, or NR1F3) is a promising target for the treatment of autoimmune diseases. RORc is a critical regulator in the production of the pro-inflammatory cytokine int
Autor:
John Liu, Stephanie Addo, Gauri Deshmukh, Wyne P. Lee, Mark Zak, Ivan Peng, Hart S. Dengler, Julia Lloyd, Simon Charles Goodacre, Nicholas Charles Ray, Eric Suto, Pawan Bir Kohli, Savita Ubhayakar, Cristine M. Quiason-Huynh, Xiumin Wu, Cornelia H. Rinderknecht, Sheerin K. Shahidi-Latham, Youngsu Kwon, Marya Liimatta, Janet Jackman, Gary Cain, Jane R. Kenny, Gary Salmon, Brent S. McKenzie, Mike Briggs, Adam R. Johnson, Kathy Barrett, Nico Ghilardi
Publikováno v:
Science translational medicine. 10(468)
Preclinical and clinical evidence indicates that a subset of asthma is driven by type 2 cytokines such as interleukin-4 (IL-4), IL-5, IL-9, and IL-13. Additional evidence predicts pathogenic roles for IL-6 and type I and type II interferons. Because
Autor:
Yuzhong Deng, Susan Summerhill, Benjamin Fauber, Maxine Norman, Alberto Gobbi, Adrian Barnard, Kerry Chapman, Adam R. Johnson, Olivier Rene, Harvey Wong, Christine Everett, Hank La, Gary Salmon, Celine Eidenschenk
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(18)
Modification of the δ-sultam ring of RORc inverse agonist 2 led to the discovery of more polar oxa-sultam 65. The less lipophilic inverse agonist (65) displayed high potency in a biochemical assay, which translated into inhibition of IL-17 productio
Publikováno v:
Cancer Research. 78:1730-1730
Charles River Laboratories (CRL) has established a powerful translational immuno-oncology platform with the capability of progressing biologics or small-molecule modulators of immune response from in vitro to in vivo assays using human and mouse vari
Autor:
Julian Blagg, Esther F. Schmid, David Fairman, Charles E. Mowbray, David C. Pryde, Gary Salmon, Kevin Beaumont
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5601-5604
The optimisation of a series of amides for C5a receptor binding and functional activity, and physicochemical properties is described. The initial hit, 1 (IC(50) 1 microM), was discovered during high throughput screening, from which highly potent C5a
Autor:
Franz Hofmann, Stuart J. Marshall, Gary Salmon, J. Thomas Peterson, Steve P. Watson, Robert Feil, Yotis A. Senis, Jocelyn M. Auger, Frank Burslem
Publikováno v:
Blood. 103:2601-2609
Glycoprotein Ib-IX-V (GPIb-IX-V) mediates platelet tethering to von Willebrand factor (VWF), recruiting platelets into the thrombus, and activates integrin αIIbβ3 through a pathway that is dependent on Src kinases. In addition, recent reports indic
Autor:
Stuart J. MARSHALL, Naoki ASAZUMA, Denise BEST, Peter WONEROW, Gary SALMON, Robert K. ANDREWS, Steve P. WATSON
Publikováno v:
Biochemical Journal. 361:297-305
It has been proposed that the receptor for von Willebrand factor (vWF), glycoprotein (GP)Ib-IX-V, signals through the same pathway as the collagen receptor, GPVI, namely via Src kinases, the Fc receptor (FcR) γ-chain and Syk, leading to tyrosine pho
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 109(3)
Previous studies in our laboratory have shown that platelets are essential for the migration of eosinophils into the lungs of allergic mice, and that this is dependent on the functional expression of platelet P-selectin. We sought to investigate whet