Zobrazeno 1 - 10 of 64 pro vyhledávání: '"Gary S. Jacob"'
1
Plecanatide, an Oral Guanylate Cyclase C Agonist Acting Locally in the Gastrointestinal Tract, Is Safe and Well-Tolerated in Single Doses
Autor: Rong Feng, John A. Foss, Stephen Comiskey, Kunwar Shailubhai, Gail M. Comer, Gary S. Jacob, Laura Barrow
Publikováno v: Digestive Diseases and Sciences. 58:2580-2586
Plecanatide, an analogue of uroguanylin, activates the guanylate cyclase C (GC-C) receptor found on the GI mucosal epithelial cells, leading to secretion of fluid, facilitating bowel movements. Plecanatide is being investigated as a potential treatme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce6afccf669443d9b2d9be36f766c85
https://doi.org/10.1007/s10620-013-2684-z
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2
Therapeutically targeting guanylate cyclase-C: computational modeling of plecanatide, a uroguanylin analog
Autor: Gary S. Jacob, Antonio Ricci, Marcella Bassetto, Andrea Brancale, Kunwar Shailubhai, Salvatore Ferla
Publikováno v: Pharmacology Research & Perspectives
Plecanatide is a recently developed guanylate cyclase‐C (GC‐C) agonist and the first uroguanylin analog designed to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS‐C). GC‐C receptors are found a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608737b3091c38ea419b52c70690ddca
https://pubmed.ncbi.nlm.nih.gov/28357122
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3
Evaluating a robust contour tracker on echocardiographic sequences
Autor: Gary S. Jacob, Andrew Blake, Miguel Mulet-Parada, J. Alison Noble
Publikováno v: Scopus-Elsevier
In this paper we present an evaluation of a robust visual image tracker on echocardiographic image sequences. We show how the tracking framework can be customized to define an appropriate shape space that describes heart shape deformations that can b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060c0278181aaec28e1d6d754929e8dd
https://doi.org/10.1016/s1361-8415(99)80017-6
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5
Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod
Autor: Donald Picker, Genesis Harris, Gary S. Jacob, Muhammad A. Khan, Timothy M. Block, Sweeta R. Choudhari, Kunwar Shailubhai
Publikováno v: Molecular Cancer Therapeutics. 6:112-121
Atiprimod is a novel anticancer and antiangiogenic drug candidate which is currently being evaluated in patients with liver carcinoid and multiple myeloma. In this study, we report that atiprimod selectively inhibited proliferation and induced apopto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6221949c44763e9461ba5d7327f84cf
https://doi.org/10.1158/1535-7163.mct-06-0561
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6
Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis
Autor: Bradley Nefsky, Gary S. Jacob, Scott E. Plevy, Vaseem Palejwala, Kunwar Shailubhai, Stephen Comiskey, John A. Foss, Krishna Priya Arjunan, Sayali Saykhedkar
To evaluate the effect of orally administered plecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models.The cyclic guanosine monophosphate (cGMP) stimulatory potency of plecanatide and dolcanatide was measured us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6e521dd7ca4c3da88adcf5ed7d7c47
https://europepmc.org/articles/PMC4635161/
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8
Imino Sugars That are Less Toxic but More Potent as Antivirals,In Vitro, Compared with N-n-Nonyl DNJ
Autor: Anand Mehta, Timothy M. Block, Raymond A. Dwek, Gary S. Jacob, Robert Jordan, Robert M. Moriarty, Ender Simsek, Serguey Ouzounov, Xuanyong Lu
Publikováno v: Antiviral Chemistry and Chemotherapy. 13:299-304
Imino sugar glucosidase inhibitors have selective antiviral activity against certain enveloped, mammalian viruses. Deoxynojirimycins (DNJs) modified by N-alkylation to contain a nine carbon atom side chain (N-n-nonyl-deoxynojirimycin; N-nonyl-DNJ, NN
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c888e5293ad2b35654d62ea4450ce4
https://doi.org/10.1177/095632020201300505
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9
Quantitative regional analysis of myocardial wall motion
Autor: Gary S. Jacob, Andrew Kelion, J. Alison Noble, Adrian P. Banning
Publikováno v: Ultrasound in Medicine & Biology. 27:773-784
This paper presents a new technique for semiautomatic quantification of regional heart function from 2-D echocardiography. It uses a novel left ventricular border tracking algorithm based on shape-space ideas that we have recently described. In this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68392f8f764bf2d019088a473600eeb
https://doi.org/10.1016/s0301-5629(01)00350-7
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10
Polysulfated Derivatives of β-Cyclodextrin andmyo-Inositol as Potent Inhibitors of the Interaction between L-Selectin and Peripheral Addressin: Implying a Requirement for Highly Clustered Sulfate Groups
Autor: Kunwar Shailubhai, S. Zaheer Abbas, Gary S. Jacob
Publikováno v: Biochemical and Biophysical Research Communications. 229:488-493
We have utilized an in vitro assay that measures the binding of an L-selectin-human Fc chimera (LS-Fc) to [35S]sulfate labelled peripheral addressin (PNAd), a 120 kDa glycoprotein ligand for L-selectin in porcine lymph nodes, to evaluate inhibitory p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9385f6158a1edce8f71ca674898ca73
https://doi.org/10.1006/bbrc.1996.1831
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