Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gary S. Bignami"'
Autor:
Patrizia Ciminiello, Olivier Chaloin, Aurelia Tubaro, Emma Dello Iacovo, Marco Pelin, Carmela Dell'Aversano, Mark A. Poli, Gary S. Bignami, Luciana Tartaglione, Martino Forino, Silvio Sosa
Publikováno v:
Journal of Natural Products. 77:351-357
Palytoxin ranks among the most potent marine biotoxins. Its lethality was well known to native Hawaiians that used to smear a "moss" containing the toxin on their spears to cause instant death to their victims. Human intoxications due to exposure to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c349fede62dc07db7c8634449d7eaabe
https://doi.org/10.1021/np4009514
https://doi.org/10.1021/np4009514
The early work of Drs. Philip Helrich, Paul Scheuer, Alfred Banner and others at the University of Hawaii in the early 1960’s on their newly-discovered compound that was soon to be known as “palytoxin” was stimulated by an early Hawaiian legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf68d1300003051f95b1ce21dd2cd6d
https://hdl.handle.net/11368/2794724
https://hdl.handle.net/11368/2794724
Publikováno v:
Toxicon. 34:1393-1397
G. S. Bignami, D. F. Waller and T. Yasumoto. Antibodies to maitotoxin elicited by immunization with toxin-fragment conjugates. Toxicon 34, 1393-1397, 1996.-Maitotoxin is a water-soluble polyether toxin produced by the benthic dinoflagellate, Gambierd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eff3e2df7559900c82a37daa522b846
https://doi.org/10.1016/s0041-0101(96)00094-3
https://doi.org/10.1016/s0041-0101(96)00094-3
Publikováno v:
Toxicon. 33:1231-1237
The ability of a tetrodotoxin (TTX)-specific monoclonal antibody to confer passive protection against lethal TTX challenge was investigated. The monoclonal antibody, T20G10, has an estimated affinity for TTX of approximately 10(-9) M and is about 50-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4413d5d3cbb87b52fcb283213b62bdca
https://doi.org/10.1016/0041-0101(95)00060-y
https://doi.org/10.1016/0041-0101(95)00060-y
Autor:
Robert A. Newman, Ronald S. Walters, John A. Benvenuto, T. J. G. Raybould, Laura Esparza, Gary S. Bignami, Martin N. Raber
Publikováno v:
Investigational New Drugs. 10:113-117
Sixteen evaluable patients with metastatic breast cancer were entered into a phase II trial of didemnin B. They received the drug at an initial dose of 5.6 mg/m2 every 21 to 28 days. Major toxicities noted were myalgia and nausea and vomiting while m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40962b07507b20dcbabaadbd6b7044b7
https://doi.org/10.1007/bf00873128
https://doi.org/10.1007/bf00873128
Autor:
Mark Poli, Gary S. Bignami, Marco De Bortoli, Emma Dello Iacovo, Patrizia Ciminiello, Carmela Dell'Aversano, Ernesto Fattorusso, Laura Grauso, Paola Lorenzon, Aurelia Tubaro, Luciana Tartaglione, Martino Forino, Chiara Florio
This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c238308d7563477a7a670272d0503789
https://hdl.handle.net/11368/2290980
https://hdl.handle.net/11368/2290980
Autor:
Katarina Svanberg, Sune Svanberg, Elisabeth McLaughlin, Stefan Andersson-Engels, Sara Pålsson, Paul Troy, Gary S. Bignami, Marcelo Soto Thompson, Ulf Gustafsson, Jody C. Oyama, Michael James DeWeert, Violeta Poskiene, Ellen Jacobson, Kristina Kriukelyte, Aurelija Vaitkuviene, Reda Ziobakiene, Johan Håkansson, Unne Stenram
Publikováno v:
Proceedings of SPIE; 4959, pp 67-76 (2003)
The use of fluorescence and reflectance spectroscopy in the analysis of cervical histopathology is a growing field of research. The majority of this research is performed with point-like probes. Typically, clinicians select probe sites visually, coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb29248a49f0b986a1add890e54bf64
https://lup.lub.lu.se/record/1126733
https://lup.lub.lu.se/record/1126733
Autor:
Gary S Bignami, Susan L. Mooberry
Publikováno v:
Cancer letters. 126(2)
Recently it has been proposed that drug-specific neutralizing antibodies may limit side-effects that occur during chemotherapy. These studies were undertaken to determine if monoclonal antibodies, 3C6 specific to paclitaxel and 8A10 specific to taxan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf84d4d8c8618cc3ab2a27d619d99f84
https://pubmed.ncbi.nlm.nih.gov/9585057
https://pubmed.ncbi.nlm.nih.gov/9585057
Publikováno v:
Journal of natural products. 58(9)
Endophytic microbes associated with the Pacific yew tree, Taxus brevifolia, were examined as potential sources of the anticancer drug taxol [1], a secondary metabolite of the host organism. The first promising organism found was the novel fungus, Tax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5765e435c112e7d141bb4817699ba79f
https://pubmed.ncbi.nlm.nih.gov/7494141
https://pubmed.ncbi.nlm.nih.gov/7494141
Autor:
Kent E. Harada, Jilanne B. Byrnes, Sean O'Malley, Belinda Alvarádo, Gary S. Bignami, Mary T. McGuire, T. J. G. Raybould, David F. Waller, Paul G. Grothaus
Publikováno v:
Journal of natural products. 58(7)
Three monoclonal antibodies with either specificity to taxol or baccatin III, or cross-reactivity with several common taxanes have been prepared and used to develop sensitive competitive-inhibition enzyme immunoassays. The hybridomas producing these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eca1824e87b453401050f9c7ed7d3eb
https://pubmed.ncbi.nlm.nih.gov/7561893
https://pubmed.ncbi.nlm.nih.gov/7561893