Type 2 diabetes and cardiometabolic risk may be associated with increase in DNA methylation of FKBP5

Autor: Robin Ortiz, Joshua J. Joseph, Richard Lee, Gary S. Wand, Sherita Hill Golden

Publikováno v: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-8 (2018)

Abstract Background Subclinical hypercortisolism and hypothalamic-pituitary-adrenal (HPA) axis dysfunction are associated with type 2 diabetes (T2DM), cardiovascular disease, and metabolic dysfunction. Intronic methylation of FKBP5 has been implicate

Externí odkaz: https://doaj.org/article/f77e208fb34346c3a3a44c8b40e7dc44

Cross-species Association Between Telomere Length and Glucocorticoid Exposure

Autor: Susan M. Webb, Alicia Santos, Anna Aulinas, Mary E. McCaul, Richard S. Lee, Gary S. Wand, Eugenia Resmini, Jenny L. Carey, Peter P. Zandi

Publikováno v: J Clin Endocrinol Metab
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

ContextChronic exposure to glucocorticoids (GCs) or stress increases the risk of medical disorders, including cardiovascular and neuropsychiatric disorders. GCs contribute to accelerated aging; however, while the link between chronic GC exposure and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93a8ce5b6650d9b02c6a078e0ba553e
https://doi.org/10.1210/clinem/dgab519

The Relationship of Varenicline Agonism of α4β2 Nicotinic Acetylcholine Receptors and Nicotine-Induced Dopamine Release in Nicotine-Dependent Humans

Autor: Mary E. McCaul, Hiroto Kuwabara, Dean Wong, Gary S. Wand, Xiaoqiang Xu, Robert F. Dannals

Publikováno v: Nicotine Tob Res

Introduction Cigarette smoking continues to be one of the most important behavioral causes of morbidity and mortality in the world. Varenicline, an α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist, has been shown to increase smoking qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aeecf0dff962585ef86d2d0465bc2c8
https://doi.org/10.1093/ntr/ntz080

The Association of Serum Aldosterone and Plasma Renin Activity with Ambulatory Blood Pressure in African Americans: The Jackson Heart Study

Autor: Neal K. Pohlman, Justin B. Echouffo-Tcheugui, Joshua J. Joseph, Gary S. Wand, Mario Sims, Daichi Shimbo, Marwah Abdalla, Willa A. Hsueh, Valery S. Effoe, Rita R. Kalyani, Guy Brock, David Kline, Wen-Chih Wu, Bjorn Kluwe, Sherita Hill Golden, Songzhu Zhao

Publikováno v: Circulation

Background: The renin-angiotensin-aldosterone system (RAAS) is an important driver of blood pressure (BP), but the association of the RAAS with ambulatory BP (ABP) and ABP monitoring phenotypes among African Americans has not been assessed. Methods:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f358226a5aaac1c3a5813a500dcc2c
https://europepmc.org/articles/PMC8789344/

Sex differences in the ACTH and cortisol response to pharmacological probes are stressor-specific and occur regardless of alcohol dependence history

Autor: Belinda E. Daniel, Jaimee L. Heffner, Gary S. Wand, Thomas J. Blom, Robert M. Anthenelli, Benjamin S. McKenna

Publikováno v: Psychoneuroendocrinology, vol 94

Women and men differ in their risk for developing stress-related conditions such as alcohol use and anxiety disorders and there are gender differences in the typical sequence in which these disorders co-occur. However, the neural systems underlying t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9281688a49d56515daefd2544986db18
https://doi.org/10.1016/j.psyneuen.2018.05.007