Zobrazeno 1 - 10
of 409
pro vyhledávání: '"Gary S, Firestein"'
Autor:
Garrett Dunlap, Aaron Wagner, Nida Meednu, Ruoqiao Wang, Fan Zhang, Jabea Cyril Ekabe, Anna Helena Jonsson, Kevin Wei, Saori Sakaue, Aparna Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Vivian P. Bykerk, Laura T. Donlin, Susan M. Goodman, Gary S. Firestein, David L. Boyle, V. Michael Holers, Larry W. Moreland, Darren Tabechian, Costantino Pitzalis, Andrew Filer, Soumya Raychaudhuri, Michael B. Brenner, Juilee Thakar, Andrew McDavid, Deepak A. Rao, Jennifer H. Anolik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify
Externí odkaz:
https://doaj.org/article/b76b85a9921847d4919133eeb47ed023
Autor:
Eddie A. James, V. Michael Holers, Radhika Iyer, E. Barton Prideaux, Navin L. Rao, Cliff Rims, Virginia S. Muir, Sylvia E. Posso, Michelle S. Bloom, Amin Zia, Serra E. Elliott, Julia Z. Adamska, Rizi Ai, R. Camille Brewer, Jennifer A. Seifert, LauraKay Moss, Saman Barzideh, M. Kristen Demoruelle, Christopher C. Striebich, Yuko Okamoto, Enkhtsogt Sainbayar, Alexandra A. Crook, Ryan A. Peterson, Lauren A. Vanderlinden, Wei Wang, David L. Boyle, William H. Robinson, Jane H. Buckner, Gary S. Firestein, Kevin D. Deane
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Molecular markers of autoimmunity, such as antibodies to citrullinated protein antigens (ACPA), are detectable prior to inflammatory arthritis (IA) in rheumatoid arthritis (RA) and may define a state that is ‘at-risk’ for future RA. Here
Externí odkaz:
https://doaj.org/article/a3d2e67207bd4673ae2092ef39c22e10
Autor:
Hyeonjeong Lee, Camilla R L Machado, Deepa Hammaker, Eunice Choi, Edward B Prideaux, Wei Wang, David L Boyle, Gary S Firestein
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0304530 (2024)
Rheumatoid arthritis (RA) is a systemic immune-mediated disease characterized by joint inflammation and destruction. The disease typically affects small joints in the hands and feet, later progressing to involve larger joints such as the knees, shoul
Externí odkaz:
https://doaj.org/article/2b85a7c05bcd4e318c6f0ff23d6ac2bb
Autor:
Aileen Y. Chang, Sarah R. Tritsch, Carlos Andres Herrera Gomez, Liliana Encinales, Andres Cadena Bonfanti, Wendy Rosales, Evelyn Mendoza-Torres, Samuel Simmens, Richard L. Amdur, Christopher N. Mores, Paige Fierbaugh, Carlos Alberto Perez Hernandez, Geraldine Avendaño, Paula Bruges Silvera, Yerlenis Galvis Crespo, Alberto David Cabana Jimenez, Jennifer Carolina Martinez Zapata, Dennys Jimenez, Estefanie Osorio-Llanes, Jairo Castellar-Lopez, Karol Suchowiecki, Karen Martins, Melissa Gregory, Ivan Zuluaga, Abigale Proctor, Alfonso Sucerquia Hernández, Leandro Sierra-Carrero, Maria Villanueva Colpas, Juan Carlos Perez Hernandez, Andres Alberto Figueroa Quast, Joaquin Andres Calderon De Barros, José Forero Mejía, Johan Penagos Ruiz, David Boyle, Gary S. Firestein, Gary L. Simon
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/bf8d89fb67e84acaad44a668d4b4a1a5
Autor:
Richard I. Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Fibroblast-like synoviocytes (FLS) are used as a model of rheumatoid arthritis synoviocytes, although cell lines derived from individual patients can have heterogeneous biology. Here the authors use a Taiji computational approach to analyze gene expr
Externí odkaz:
https://doaj.org/article/c8daa11cab114d9a8d1dd398242e20b7
Autor:
V. Michael Holers, Kristine A. Kuhn, M. Kristen Demoruelle, Jill M. Norris, Gary S. Firestein, Eddie A. James, William H. Robinson, Jane H. Buckner, Kevin D. Deane
Publikováno v:
Rheumatology & Autoimmunity, Vol 2, Iss 3, Pp 109-119 (2022)
Abstract In seropositive rheumatoid arthritis (RA), the onset of clinically apparent inflammatory arthritis (IA) is typically preceded by a prolonged period of autoimmunity manifest by the presence of circulating autoantibodies that can include antib
Externí odkaz:
https://doaj.org/article/a023ec5f97084f0d8aed3f54c68b8020
Autor:
Vladislav Tsaltskan, Katherine Nguyen, Christina Eaglin, V. Michael Holers, Kevin D. Deane, Gary S. Firestein
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 7, Pp 623-630 (2022)
Objective Traditional nondigital methods of participant recruitment for clinical research studies in rheumatology can be costly and inefficient, particularly for recruitment of underserved populations. We aimed to address this need by evaluating two
Externí odkaz:
https://doaj.org/article/69b997f410a745d3b6c6c30bbab64508
Autor:
Cecilia Ansalone, Richard I. Ainsworth, Gyrid Nygaard, Rizi Ai, Edward B. Prideaux, Deepa Hammaker, Narayanan B. Perumal, Ken Weichert, Frances Tung, Lalitha Kodandapani, J. Michael Sauder, Elisabeth C. Mertsching, Robert J. Benschop, David L. Boyle, Wei Wang, Gary S. Firestein
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 4, Pp 288-299 (2022)
Objective Fibroblast‐like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype. We i
Externí odkaz:
https://doaj.org/article/7bf9364f9ed048b68c6e9061d4e747da
Autor:
Jan M Hughes-Austin, Ronit Katz, Darcy S Majka, Michael H Criqui, William H Robinson, Gary S Firestein, W Gregory Hundley, Joachim H Ix
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0291967 (2023)
BackgroundAntibodies to citrullinated protein antigens have been linked to altered left ventricular (LV) structure and function in patients with rheumatoid arthritis (RA). Serum reactivity to several citrullinated protein/peptide antigens has been id
Externí odkaz:
https://doaj.org/article/775a2e0975764ace8e44e85ac2229d98
Autor:
Elaine H. Morrato, Lindsay A. Lennox, James W. Dearing, Anne T. Coughlan, Elaina S. Gano, Doug McFadden, Nallely Mora, Harold Alan Pincus, Gary S. Firestein, Robert Toto, Steven E. Reis
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
The ACT Network was funded by NIH to provide investigators from across the Clinical and Translational Science Award (CTSA) Consortium the ability to directly query national federated electronic health record (EHR) data for cohort discovery and feasib
Externí odkaz:
https://doaj.org/article/c7b0099de2734a09819a61a23d6e60d5