Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Gary Rudnick"'
Autor:
Isha Singh, Anubha Seth, Christian B. Billesbølle, Joao Braz, Ramona M. Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Vladimir M. Pogorelov, Parnian Lak, Henry O’Donnell, Walter Sandtner, John J. Irwin, Bryan L. Roth, Allan I. Basbaum, William C. Wetsel, Aashish Manglik, Brian K. Shoichet, Gary Rudnick
Publikováno v:
Cell, vol 186, iss 10
The serotonin transporter (SERT) removes synaptic serotonin and is the target of anti-depressant drugs. SERT adopts three conformations: outward-open, occluded, and inward-open. All known inhibitors target the outward-open state except ibogaine, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d58613557bb5172a1708dafaffcd158
https://escholarship.org/uc/item/5cg0t59n
https://escholarship.org/uc/item/5cg0t59n
Autor:
Gary Rudnick, Stefan Bröer
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Members of the solute carrier family 6 (SLC6) of sodium- and (sometimes chloride-) dependent neurotransmitter transporters [32, 2, 23, 75] are primarily plasma membrane located and may be divided into four subfamilies that transport monoamines, GABA,
Autor:
Isha Singh, Anubha Seth, Christian B. Billesbølle, Joao Braz, Ramona M. Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Parnian Lak, Henry O’Donnell, Walter Sandtner, Bryan L. Roth, Allan I. Basbaum, William C. Wetsel, Aashish Manglik, Brian K. Shoichet, Gary Rudnick
SUMMARYThe serotonin transporter (SERT) removes synaptic serotonin and is the target of anti-depressant drugs. SERT adopts three conformations: outward-open, occluded, and inward-open. All known inhibitors target the outward-open state except ibogain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5895a65a89afbdc8ac539061b017cdf2
https://doi.org/10.1101/2022.06.13.495991
https://doi.org/10.1101/2022.06.13.495991
Autor:
Gary Rudnick
Publikováno v:
Neurochem Res
Baruch Kanner and this author have had parallel careers investigating neurotransmitter transporters. At multiple times during their careers, they have found themselves collaborating or competing, but always learning from each other. This commentary e
Autor:
Gary Rudnick
Publikováno v:
The Journal of General Physiology
Natural resistance-associated macrophage protein (Nramp) transporters enable uptake of essential transition metal micronutrients in numerous biological contexts. These proteins are believed to function as secondary transporters that harness the elect
Autor:
Walter Sandtner, Gary Rudnick
Publikováno v:
The Journal of General Physiology
Rudnick and Sandtner review the history of serotonin transporter research in light of structural and electrophysiological advances.
Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), w
Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), w
Autor:
Ntumba Sangwa, Lucy R. Forrest, Yuan-Wei Zhang, Gary Rudnick, Stacy Uchendu, Vanessa Leone, Richard T. Bradshaw
Publikováno v:
Proc Natl Acad Sci U S A
The human GlyT1 glycine transporter requires chloride for its function. However, the mechanism by which Cl-exerts its influence is unknown. To examine the role that Cl-plays in the transport cycle, we measured the effect of Cl-on both glycine binding
Autor:
Jonathan S. Marvin, Lindsay P. Cameron, Steffen Sinning, Jacob P. Keller, Duncan Temple Lang, Jennifer A. Prescher, Phillip M. Borden, Elizabeth K. Unger, Susan G. Amara, Veronica A. Alvarez, Gary Rudnick, Chunyang Dong, Jane Carlen, Meghan E. Flanigan, Loren L. Looger, Samantha Hartanto, Ruqiang Liang, Vladimir Yarov-Yarovoy, Amol V. Shivange, Michael Altermatt, Thomas L. Kash, Andrew J. Fisher, Aya Matsui, David A. Jaffe, Lin Tian, Samba Banala, Suzanne M. Underhill, Luke D. Lavis, David E. Olson, Grace O. Mizuno, Zi Yao, Olivia J Hon, Junqing Sun, Viviana Gradinaru, Henry A. Lester
Publikováno v:
Cell, vol 183, iss 7
Unger, E K, Keller, J P, Altermatt, M, Liang, R, Matsui, A, Dong, C, Hon, O J, Yao, Z, Sun, J, Banala, S, Flanigan, M E, Jaffe, D A, Hartanto, S, Carlen, J, Mizuno, G O, Borden, P M, Shivange, A V, Cameron, L P, Sinning, S, Underhill, S M, Olson, D E, Amara, S G, Temple Lang, D, Rudnick, G, Marvin, J S, Lavis, L D, Lester, H A, Alvarez, V A, Fisher, A J, Prescher, J A, Kash, T L, Yarov-Yarovoy, V, Gradinaru, V, Looger, L L & Tian, L 2020, ' Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning ', Cell, vol. 183, no. 7, pp. 1986-2002.e26 . https://doi.org/10.1016/j.cell.2020.11.040
Cell
Unger, E K, Keller, J P, Altermatt, M, Liang, R, Matsui, A, Dong, C, Hon, O J, Yao, Z, Sun, J, Banala, S, Flanigan, M E, Jaffe, D A, Hartanto, S, Carlen, J, Mizuno, G O, Borden, P M, Shivange, A V, Cameron, L P, Sinning, S, Underhill, S M, Olson, D E, Amara, S G, Temple Lang, D, Rudnick, G, Marvin, J S, Lavis, L D, Lester, H A, Alvarez, V A, Fisher, A J, Prescher, J A, Kash, T L, Yarov-Yarovoy, V, Gradinaru, V, Looger, L L & Tian, L 2020, ' Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning ', Cell, vol. 183, no. 7, pp. 1986-2002.e26 . https://doi.org/10.1016/j.cell.2020.11.040
Cell
Serotonin plays a central role in cognition and is the target of most pharmaceuticals for psychiatric disorders. Existing drugs have limited efficacy; creation of improved versions will require better understanding of serotonergic circuitry, which ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883a30717e65d8243ed9ec30ec493e73
https://escholarship.org/uc/item/7n79j6qj
https://escholarship.org/uc/item/7n79j6qj
Autor:
Stefan Bröer, Gary Rudnick
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Members of the solute carrier family 6 (SLC6) of sodium- and (sometimes chloride-) dependent neurotransmitter transporters [29, 22, 70] are primarily plasma membrane located and may be divided into four subfamilies that transport monoamines, GABA, gl